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Clinical Manifestations of COVID-19

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Coronavirus Disease - COVID-19

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1318))

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third coronavirus causing an outbreak in the twenty-first century. It is related to a contagious coronavirus disease (COVID-19), which its high pace of spreading allowed it to lie to the whole world and be turned into a pandemic only a few months after the identification of the first case. Currently, the reverse transcription-polymerase chain reaction (RT-PCR) test of throat swap is the gold standard of diagnosis; however, several studies have reported false-negative results with non-ideal sensitivity. Because this pandemic constitutes a significant burden on global healthcare systems and due to the high transmission rate of the virus, an accurate diagnosis algorithm is needed to reduce the missing case number. A comprehensive clinical examination and taking a history of all systems (not just limited to the respiratory system) combined with hematologic laboratory tests and chest imaging can lead to a sensitive diagnosis, severity assessment, and RT-PCT test interpretation. This chapter focuses on clinical characteristics, hematologic laboratory, and chest imaging features in COVID-19.

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References

  • Ahanchian H, Moazzen N, Faroughi MSD, Khalighi N, Khoshkhui M, Aelami MH, Haghi NSM, Rezaei N (2020) COVID-19 in a child with primary specific antibody deficiency

    Google Scholar 

  • Ahmadi M, Saffarzadeh N, Habibi MA, Hajiesmaeili F, Rezaei N (2020) Colon cancer and SARS-CoV-2: impact of ACE2 expression in susceptibility to COVID-19. bioRxiv

    Google Scholar 

  • Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, Tao Q, Sun Z, Xia L (2020) Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology 200642. https://doi.org/10.1148/radiol.2020200642

  • Akerlund A, Bende M, Murphy C (1995) Olfactory threshold and nasal mucosal changes in experimentally induced common cold. Acta Otolaryngol 115(1):88–92. https://doi.org/10.3109/00016489509133353

    Article  PubMed  CAS  Google Scholar 

  • Arabi YM, Balkhy HH, Hayden FG, Bouchama A, Luke T, Baillie JK, Al-Omari A, Hajeer AH, Senga M, Denison MR, Nguyen-Van-Tam JS, Shindo N, Bermingham A, Chappell JD, Van Kerkhove MD, Fowler RA (2017) Middle East respiratory syndrome. N Engl J Med 376(6):584–594. https://doi.org/10.1056/NEJMsr1408795

    Article  PubMed  PubMed Central  Google Scholar 

  • Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S, Al-Barrak A, Flemban H, Al-Nassir WN, Balkhy HH, Al-Hakeem RF, Makhdoom HQ, Zumla AI, Memish ZA (2013) Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 13(9):752–761. https://doi.org/10.1016/s1473-3099(13)70204-4

    Article  PubMed  PubMed Central  Google Scholar 

  • Babaha F, Rezaei N (2020) Primary immunodeficiency diseases in COVID-19 pandemic: a predisposing or protective factor? Am J Med Sci. https://doi.org/10.1016/j.amjms.2020.07.027

  • Bahrami A, Vafapour M, Moazzami B, Rezaei N (2020) Hyperinflammatory shock related to COVID-19 in a patient presenting with multisystem inflammatory syndrome in children: first case from Iran. J Paediatr Child Health. https://doi.org/10.1111/jpc.15048

  • Baig AM, Khaleeq A, Ali U, Syeda H (2020) Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 11(7):995–998. https://doi.org/10.1021/acschemneuro.0c00122

    Article  PubMed  CAS  Google Scholar 

  • Basiri A, Heidari A, Nadi MF, Fallahy MTP, Nezamabadi SS, Sedighi M, Saghazadeh A, Rezaei N (2020a) Microfluidic devices for detection of RNA viruses. Rev Med Virol:e2154. doi:https://doi.org/10.1002/rmv.2154

  • Basiri A, Pazhouhnia Z, Beheshtizadeh N, Hoseinpour M, Saghazadeh A, Rezaei N (2020b) Regenerative medicine in COVID-19 treatment: real opportunities and range of promises. Stem Cell Rev Rep:1–13. https://doi.org/10.1007/s12015-020-09994-5

  • Bellosta R, Luzzani L, Natalini G, Pegorer MA, Attisani L, Cossu LG, Ferrandina C, Fossati A, Conti E, Bush RL, Piffaretti G (2020) Acute limb ischemia in patients with COVID-19 pneumonia. J Vasc Surg. https://doi.org/10.1016/j.jvs.2020.04.483

  • Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, Goh YY, Humphries F, Jager HR, Losseff NA, Perry RJ, Shah S, Simister RJ, Turner D, Chandratheva A, Werring DJ (2020) Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry. https://doi.org/10.1136/jnnp-2020-323586

  • Bombardini T, Picano E (2020) Angiotensin-converting enzyme 2 as the molecular bridge between epidemiologic and clinical features of COVID-19. Can J Cardiol 36(5):784.e781–784.e782. https://doi.org/10.1016/j.cjca.2020.03.026

  • Brann D, Tsukahara T, Weinreb C, Logan DW, Datta SR (2020) Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients. bioRxiv:2020.2003.2025.009084. https://doi.org/10.1101/2020.03.25.009084

  • Brann JH, Firestein SJ (2014) A lifetime of neurogenesis in the olfactory system. Front Neurosci 8:182. https://doi.org/10.3389/fnins.2014.00182

    Article  PubMed  PubMed Central  Google Scholar 

  • Cao Y, Liu X, Xiong L, Cai K (2020) Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis. J Med Virol. https://doi.org/10.1002/jmv.25822

  • Chai X, Hu L, Zhang Y, Han W, Lu Z, Ke A, Zhou J, Shi G, Fang N, Fan J, Cai J, Fan J, Lan F (2020) Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv:2020.2002.2003.931766. https://doi.org/10.1101/2020.02.03.931766

  • Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H, Zhang X, Zhang M, Wu S, Song J, Chen T, Han M, Li S, Luo X, Zhao J, Ning Q (2020a) Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest 130(5):2620–2629. https://doi.org/10.1172/jci137244

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen J, Qi T, Liu L, Ling Y, Qian Z, Li T, Li F, Xu Q, Zhang Y, Xu S, Song Z, Zeng Y, Shen Y, Shi Y, Zhu T, Lu H (2020b) Clinical progression of patients with COVID-19 in Shanghai, China. J Infect 80(5):e1–e6. https://doi.org/10.1016/j.jinf.2020.03.004

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen L, Deng C, Chen X, Zhang X, Chen B, Yu H, Qin Y, Xiao K, Zhang H, Sun X (2020c) Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study. Acta Ophthalmol. https://doi.org/10.1111/aos.14472

  • Chen Y, Liu Q, Guo D (2020d) Emerging coronaviruses: genome structure, replication, and pathogenesis. J Med Virol 92(4):418–423. https://doi.org/10.1002/jmv.25681

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cheung KS, Hung IF, Chan PP, Lung KC, Tso E, Liu R, Ng YY, Chu MY, Chung TW, Tam AR, Yip CC, Leung KH, Yim-Fong Fung A, Zhang RR, Lin Y, Cheng HM, Zhang AJ, To KK, Chan KH, Yuen KY, Leung WK (2020) Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis. Gastroenterology. https://doi.org/10.1053/j.gastro.2020.03.065

  • Cleary SJ, Pitchford SC, Amison RT, Carrington R, Robaina Cabrera CL, Magnen M, Looney MR, Gray E, Page CP (2020) Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology. Br J Pharmacol. https://doi.org/10.1111/bph.15143

  • Cole-Jeffrey CT, Liu M, Katovich MJ, Raizada MK, Shenoy V (2015) ACE2 and microbiota: emerging targets for cardiopulmonary disease therapy. J Cardiovasc Pharmacol 66(6):540–550. https://doi.org/10.1097/fjc.0000000000000307

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dane B, Brusca-Augello G, Kim D, Katz DS (2020) Unexpected findings of coronavirus disease (COVID-19) at the lung bases on abdominopelvic CT. AJR Am J Roentgenol:1–4. https://doi.org/10.2214/ajr.20.23240

  • Danilczyk U, Penninger JM (2006) Angiotensin-converting enzyme II in the heart and the kidney. Circ Res 98(4):463–471. https://doi.org/10.1161/01.RES.0000205761.22353.5f

    Article  PubMed  CAS  Google Scholar 

  • Darbeheshti F, Rezaei N (2020) Genetic predisposition models to COVID-19 infection. Med Hypotheses 142:109818. https://doi.org/10.1016/j.mehy.2020.109818

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • de Masson A, Bouaziz JD, Sulimovic L, Cassius C, Jachiet M, Ionescu MA, Rybojad M, Bagot M, Duong TA (2020) Chilblains are a common cutaneous finding during the COVID-19 pandemic: a retrospective nationwide study from France. J Am Acad Dermatol. https://doi.org/10.1016/j.jaad.2020.04.161

  • Deng Y, Liu W, Liu K, Fang YY, Shang J, Zhou L, Wang K, Leng F, Wei S, Chen L, Liu HG (2020) Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study. Chin Med J (Engl). https://doi.org/10.1097/cm9.0000000000000824

  • Dong X, Cao YY, Lu XX, Zhang JJ, Du H, Yan YQ, Akdis CA, Gao YD (2020) Eleven faces of coronavirus disease 2019. Allergy. https://doi.org/10.1111/all.14289

  • Ebrille E, Lucciola MT, Amellone C, Ballocca F, Orlando F, Giammaria M (2020) Syncope as the presenting symptom of COVID-19 infection. HeartRhythm Case Rep. https://doi.org/10.1016/j.hrcr.2020.04.015

  • Fathi N, Rezaei N (2020) Lymphopenia in COVID-19: therapeutic opportunities. Cell Biol Int 44(9):1792–1797. https://doi.org/10.1002/cbin.11403

    Article  PubMed  CAS  Google Scholar 

  • Ferreira AJ, Moraes PL, Foureaux G, Andrade AB, Santos RA, Almeida AP (2011) The angiotensin-(1-7)/Mas receptor axis is expressed in sinoatrial node cells of rats. J Histochem Cytochem 59(8):761–768. https://doi.org/10.1369/0022155411411712

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fini MB (2020) Oral saliva and CVID-19. Oral Oncol:104821

    Google Scholar 

  • Fung G, Luo H, Qiu Y, Yang D, McManus B (2016) Myocarditis. Circ Res 118(3):496–514. https://doi.org/10.1161/CIRCRESAHA.115.306573

    Article  PubMed  CAS  Google Scholar 

  • Galougahi MK, Ghorbani J, Bakhshayeshkaram M, Naeini AS, Haseli S (2020) Olfactory bulb magnetic resonance imaging in SARS-CoV-2-induced anosmia: the first report. Acad Radiol. https://doi.org/10.1016/j.acra.2020.04.002

  • Galvan Casas C, Catala A, Carretero Hernandez G, Rodriguez-Jimenez P, Fernandez Nieto D, Rodriguez-Villa Lario A, Navarro Fernandez I, Ruiz-Villaverde R, Falkenhain D, Llamas Velasco M, Garcia-Gavin J, Baniandres O, Gonzalez-Cruz C, Morillas-Lahuerta V, Cubiro X, Figueras Nart I, Selda-Enriquez G, Romani J, Fusta-Novell X, Melian-Olivera A, Roncero Riesco M, Burgos-Blasco P, Sola Ortigosa J, Feito Rodriguez M, Garcia-Doval I (2020) Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol. https://doi.org/10.1111/bjd.19163

  • Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, Satlin MJ, Campion TR Jr, Nahid M, Ringel JB, Hoffman KL, Alshak MN, Li HA, Wehmeyer GT, Rajan M, Reshetnyak E, Hupert N, Horn EM, Martinez FJ, Gulick RM, Safford MM (2020) Clinical characteristics of Covid-19 in New York City. N Engl J Med. https://doi.org/10.1056/NEJMc2010419

  • Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382(18):1708–1720. https://doi.org/10.1056/NEJMoa2002032

    Article  PubMed  CAS  Google Scholar 

  • Gupta N, Zhao YY, Evans CE (2019) The stimulation of thrombosis by hypoxia. Thromb Res 181:77–83. https://doi.org/10.1016/j.thromres.2019.07.013

    Article  PubMed  CAS  Google Scholar 

  • Hajifathalian K, Krisko T, Mehta A, Kumar S, Schwartz R, Fortune B, Sharaiha R (2020) Gastrointestinal and hepatic manifestations of 2019 novel coronavirus disease in a large cohort of infected patients from New York: clinical implications. Gastroenterology. https://doi.org/10.1053/j.gastro.2020.05.010

  • Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H (2004) Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 203(2):631–637. https://doi.org/10.1002/path.1570

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hanaei S, Rezaei N (2020) COVID-19: developing from an outbreak to a pandemic. Arch Med Res. https://doi.org/10.1016/j.arcmed.2020.04.021

  • He Z, Zhao C, Dong Q, Zhuang H, Song S, Peng G, Dwyer DE (2005) Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets. Int J Infect Dis 9(6):323–330. https://doi.org/10.1016/j.ijid.2004.07.014

    Article  PubMed  PubMed Central  Google Scholar 

  • Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, Collange O, Boulay C, Fafi-Kremer S, Ohana M, Anheim M, Meziani F (2020) Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. https://doi.org/10.1056/NEJMc2008597

  • Henry BM, de Oliveira MHS, Benoit J, Lippi G (2020) Gastrointestinal symptoms associated with severity of coronavirus disease 2019 (COVID-19): a pooled analysis. Intern Emerg Med. https://doi.org/10.1007/s11739-020-02329-9

  • Hick JL, Biddinger PD (2020) Novel coronavirus and old lessons – preparing the health system for the pandemic. N Engl J Med 382(20):e55. https://doi.org/10.1056/NEJMp2005118

    Article  PubMed  CAS  Google Scholar 

  • Himoto Y, Sakata A, Kirita M, Hiroi T, Kobayashi KI, Kubo K, Kim H, Nishimoto A, Maeda C, Kawamura A, Komiya N, Umeoka S (2020) Diagnostic performance of chest CT to differentiate COVID-19 pneumonia in non-high-epidemic area in Japan. Jpn J Radiol 38(5):400–406. https://doi.org/10.1007/s11604-020-00958-w

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Hjelmesaeth J, Skaare D (2020) Loss of smell or taste as the only symptom of COVID-19. Tidsskr Nor Laegeforen 140(7). https://doi.org/10.4045/tidsskr.20.0287

  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B (2020a) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395(10223):497–506. https://doi.org/10.1016/s0140-6736(20)30183-5

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Huang R, Zhu L, Xue L, Liu L, Yan X, Wang J, Zhang B, Xu T, Ji F, Zhao Y, Cheng J, Wang Y, Shao H, Hong S, Cao Q, Li C, Zhao XA, Zou L, Sang D, Zhao H, Guan X, Chen X, Shan C, Xia J, Chen Y, Yan X, Wei J, Zhu C, Wu C (2020b) Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center study. PLoS Negl Trop Dis 14(5):e0008280. https://doi.org/10.1371/journal.pntd.0008280

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jabbari P, Jabbari F, Ebrahimi S, Rezaei N (2020) COVID-19: a chimera of two pandemics. Disaster Med Public Health Prep:1–2. https://doi.org/10.1017/dmp.2020.223

  • Jabbari P, Rezaei N (2020) With risk of reinfection, is COVID-19 here to stay? Disaster Med Public Health Prep:1. https://doi.org/10.1017/dmp.2020.274

  • Jahanshahlu L, Rezaei N (2020a) Central nervous system involvement in COVID-19. Arch Med Res. https://doi.org/10.1016/j.arcmed.2020.05.016

  • Jahanshahlu L, Rezaei N (2020b) Monoclonal antibody as a potential anti-COVID-19. Biomed Pharmacother = Biomedecine & pharmacotherapie 129:110337. https://doi.org/10.1016/j.biopha.2020.110337

    Article  CAS  Google Scholar 

  • Jazieh AR, Alenazi TH, Alhejazi A, Al Safi F, Al Olayan A (2020) Outcome of oncology patients infected with coronavirus. JCO Glob Oncol (6):471–475. https://doi.org/10.1200/go.20.00064

  • Ji M, Yuan L, Shen W, Lv J, Li Y, Li M, Lu X, Hu L, Dong W (2020) Characteristics of disease progress in patients with coronavirus disease 2019 in Wuhan, China. Epidemiol Infect 148:e94. https://doi.org/10.1017/s0950268820000977

    Article  PubMed  CAS  Google Scholar 

  • Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, Hao SR, Jia HY, Cai H, Zhang XL, Yu GD, Xu KJ, Wang XY, Gu JQ, Zhang SY, Ye CY, Jin CL, Lu YF, Yu X, Yu XP, Huang JR, Xu KL, Ni Q, Yu CB, Zhu B, Li YT, Liu J, Zhao H, Zhang X, Yu L, Guo YZ, Su JW, Tao JJ, Lang GJ, Wu XX, Wu WR, Qv TT, Xiang DR, Yi P, Shi D, Chen Y, Ren Y, Qiu YQ, Li LJ, Sheng J, Yang Y (2020) Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut 69(6):1002–1009. https://doi.org/10.1136/gutjnl-2020-320926

    Article  PubMed  CAS  Google Scholar 

  • Joob B, Wiwanitkit V (2020) COVID-19 can present with a rash and be mistaken for dengue. J Am Acad Dermatol 82(5):e177. https://doi.org/10.1016/j.jaad.2020.03.036

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kafieh R, Arian R, Saeedizadeh N, Minaee S, Yadav SK, Vaezi A, Rezaei N, Javanmard SH (2020) COVID-19 in Iran: a deeper look into the future. medRxiv

    Google Scholar 

  • Kandemirli SG, Dogan L, Sarikaya ZT, Kara S, Akinci C, Kaya D, Kaya Y, Yildirim D, Tuzuner F, Yildirim MS, Ozluk E, Gucyetmez B, Karaarslan E, Koyluoglu I, Demirel Kaya HS, Mammadov O, Kisa Ozdemir I, Afsar N, Citci Yalcinkaya B, Rasimoglu S, Guduk DE, Kedir Jima A, Ilksoz A, Ersoz V, Yonca Eren M, Celtik N, Arslan S, Korkmazer B, Dincer SS, Gulek E, Dikmen I, Yazici M, Unsal S, Ljama T, Demirel I, Ayyildiz A, Kesimci I, Bolsoy Deveci S, Tutuncu M, Kizilkilic O, Telci L, Zengin R, Dincer A, Akinci IO, Kocer N (2020) Brain MRI findings in patients in the intensive care unit with COVID-19 infection. Radiology:201697. https://doi.org/10.1148/radiol.2020201697

  • Karimi-Galougahi M, Yousefi-Koma A, Bakhshayeshkaram M, Raad N, Haseli S (2020) (18)FDG PET/CT scan reveals hypoactive orbitofrontal cortex in anosmia of COVID-19. Acad Radiol. https://doi.org/10.1016/j.acra.2020.04.030

  • Kir D, Mohan C, Sancassani R (2020) HEART BRAKE – an unusual cardiac manifestation of coronavirus disease 2019 (COVID-19). JACC Case Rep. https://doi.org/10.1016/j.jaccas.2020.04.026

  • Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM (2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med 11(8):875–879. https://doi.org/10.1038/nm1267

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lau SK, Woo PC, Li KS, Tsang AK, Fan RY, Luk HK, Cai JP, Chan KH, Zheng BJ, Wang M, Yuen KY (2015) Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports the murine origin of Betacoronavirus 1 and has implications for the ancestor of Betacoronavirus lineage A. J Virol 89(6):3076–3092. https://doi.org/10.1128/jvi.02420-14

    Article  PubMed  CAS  Google Scholar 

  • Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, Dequanter D, Blecic S, El Afia F, Distinguin L, Chekkoury-Idrissi Y, Hans S, Delgado IL, Calvo-Henriquez C, Lavigne P, Falanga C, Barillari MR, Cammaroto G, Khalife M, Leich P, Souchay C, Rossi C, Journe F, Hsieh J, Edjlali M, Carlier R, Ris L, Lovato A, De Filippis C, Coppee F, Fakhry N, Ayad T, Saussez S (2020) Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. https://doi.org/10.1007/s00405-020-05965-1

  • Lescure FX, Bouadma L, Nguyen D, Parisey M, Wicky PH, Behillil S, Gaymard A, Bouscambert-Duchamp M, Donati F, Le Hingrat Q, Enouf V, Houhou-Fidouh N, Valette M, Mailles A, Lucet JC, Mentre F, Duval X, Descamps D, Malvy D, Timsit JF, Lina B, van-der-Werf S, Yazdanpanah Y (2020) Clinical and virological data of the first cases of COVID-19 in Europe: a case series. Lancet Infect Dis. https://doi.org/10.1016/s1473-3099(20)30200-0

  • Levi M, Ten Cate H (1999) Disseminated intravascular coagulation. N Engl J Med 341(8):586–592. https://doi.org/10.1056/nejm199908193410807

    Article  PubMed  CAS  Google Scholar 

  • Li K, Fang Y, Li W, Pan C, Qin P, Zhong Y, Liu X, Huang M, Liao Y, Li S (2020a) CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19). Eur Radiol. https://doi.org/10.1007/s00330-020-06817-6

  • Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, Zhang HY, Sun W, Wang Y (2020b) COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. https://doi.org/10.1002/jmv.25757

  • Li YC, Bai WZ, Hashikawa T (2020c) The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. https://doi.org/10.1002/jmv.25728

  • Liu W, Tao ZW, Wang L, Yuan ML, Liu K, Zhou L, Wei S, Deng Y, Liu J, Liu HG, Yang M, Hu Y (2020) Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin Med J 133(9):1032–1038. https://doi.org/10.1097/cm9.0000000000000775

    Article  PubMed  PubMed Central  Google Scholar 

  • Lotfi M, Hamblin MR, Rezaei N (2020) COVID-19: transmission, prevention, and potential therapeutic opportunities. Clinica Chimica Acta 508:254–266. https://doi.org/10.1016/j.cca.2020.05.044

    Article  CAS  Google Scholar 

  • Lotfi M, Rezaei N (2020) SARS-CoV-2: a comprehensive review from pathogenicity of the virus to clinical consequences. J Med Virol. https://doi.org/10.1002/jmv.26123

  • Luo S, Zhang X, Xu H (2020) Don’t overlook digestive symptoms in patients with 2019 novel coronavirus disease (COVID-19). Clin Gastroenterol Hepatol 18(7):1636–1637. https://doi.org/10.1016/j.cgh.2020.03.043

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Magrone T, Magrone M, Jirillo E (2020) Focus on receptors for coronaviruses with special reference to angiotensin-converting enzyme 2 as a potential drug target – a perspective. Endocr Metab Immune Disord Drug Targets. https://doi.org/10.2174/1871530320666200427112902

  • Mansourabadi AH, Sadeghalvad M, Mohammadi-Motlagh HR, Rezaei N (2020) The immune system as a target for therapy of SARS-CoV-2: a systematic review of the current immunotherapies for COVID-19. Life Sci 258:118185. https://doi.org/10.1016/j.lfs.2020.118185

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2020.1127

  • Marzano AV, Genovese G, Fabbrocini G, Pigatto P, Monfrecola G, Piraccini BM, Veraldi S, Rubegni P, Cusini M, Caputo V, Rongioletti F, Berti E, Calzavara-Pinton P (2020) Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients. J Am Acad Dermatol. https://doi.org/10.1016/j.jaad.2020.04.044

  • Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ (2020) COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395(10229):1033–1034. https://doi.org/10.1016/s0140-6736(20)30628-0

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Menni C, Valdes A, Freydin MB, Ganesh S, El-Sayed Moustafa J, Visconti A, Hysi P, Bowyer RCE, Mangino M, Falchi M, Wolf J, Steves C, Spector T (2020) Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection. medRxiv:2020.2004.2005.20048421. https://doi.org/10.1101/2020.04.05.20048421

  • Mirbeyk M, Rezaei N (2020) The impact of COVID-19 on pregnancy and neonatal health: a systematic review.

    Google Scholar 

  • Moazzami B, Razavi-Khorasani N, Dooghaie Moghadam A, Farokhi E, Rezaei N (2020) COVID-19 and telemedicine: Immediate action required for maintaining healthcare providers well-being. J Clin Virol 126:104345. https://doi.org/10.1016/j.jcv.2020.104345

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mohamed K, Rodríguez-Román E, Rahmani F, Zhang H, Ivanovska M, Makka SA, Joya M, Makuku R, Islam MS, Radwan N, Rahmah L, Goda R, Abarikwu SO, Shaw M, Zoghi S, Irtsyan S, Ling I, Cseprekal O, Faten AB, Hazar Sayar E, Soloukey C, Grancini G, Rezaei N (2020a) Borderless collaboration is needed for COVID-19 – a disease that knows no borders. Infect Control Hosp Epidemiol:1–2. https://doi.org/10.1017/ice.2020.162

  • Mohamed K, Yazdanpanah N, Saghazadeh A, Rezaei N (2020b) Computational drug discovery and repurposing for the treatment of Covid-19: a systematic review. Available at SSRN 3583748

    Google Scholar 

  • Momtazmanesh S, Ochs HD, Uddin LQ, Perc M, Routes JM, Vieira DN, Al-Herz W, Baris S, Prando C, Rosivall L, Abdul Latiff AH, Ulrichs T, Roudenok V, Aldave Becerra JC, Salunke DB, Goudouris E, Condino-Neto A, Stashchak A, Kryvenko O, Stashchak M, Bondarenko A, Rezaei N (2020) All together to fight COVID-19. Am J Trop Med Hyg 102(6):1181–1183. https://doi.org/10.4269/ajtmh.20-0281

    Article  PubMed  PubMed Central  Google Scholar 

  • Moradian N, Ochs HD, Sedikies C, Hamblin MR, Camargo CA Jr, Martinez JA, Biamonte JD, Abdollahi M, Torres PJ, Nieto JJ, Ogino S, Seymour JF, Abraham A, Cauda V, Gupta S, Ramakrishna S, Sellke FW, Sorooshian A, Wallace Hayes A, Martinez-Urbistondo M, Gupta M, Azadbakht L, Esmaillzadeh A, Kelishadi R, Esteghamati A, Emam-Djomeh Z, Majdzadeh R, Palit P, Badali H, Rao I, Saboury AA, Jagan Mohan Rao L, Ahmadieh H, Montazeri A, Fadini GP, Pauly D, Thomas S, Moosavi-Movahed AA, Aghamohammadi A, Behmanesh M, Rahimi-Movaghar V, Ghavami S, Mehran R, Uddin LQ, Von Herrath M, Mobasher B, Rezaei N (2020) The urgent need for integrated science to fight COVID-19 pandemic and beyond. J Transl Med 18(1):205. https://doi.org/10.1186/s12967-020-02364-2

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nasab MG, Saghazadeh A, Rezaei N (2020) SARS-CoV-2-A tough opponent for the immune system. Arch Med Res. https://doi.org/10.1016/j.arcmed.2020.05.020

  • Nie S, Han S, Ouyang H, Zhang Z (2020) Coronavirus disease 2019-related dyspnea cases difficult to interpret using chest computed tomography. Respir Med 167:105951. https://doi.org/10.1016/j.rmed.2020.105951

    Article  PubMed  PubMed Central  Google Scholar 

  • Nobel YR, Phipps M, Zucker J, Lebwohl B, Wang TC, Sobieszczyk ME, Freedberg DE (2020) Gastrointestinal symptoms and COVID-19: case-control study from the United States. Gastroenterology. https://doi.org/10.1053/j.gastro.2020.04.017

  • Organization WH (2020) Coronavirus disease 2019 (COVID-19) Situation Report-130

    Google Scholar 

  • Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP, De Leacy RA, Shigematsu T, Ladner TR, Yaeger KA, Skliut M, Weinberger J, Dangayach NS, Bederson JB, Tuhrim S, Fifi JT (2020) Large-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med 382(20):e60. https://doi.org/10.1056/NEJMc2009787

    Article  PubMed  Google Scholar 

  • Pan F, Ye T, Sun P, Gui S, Liang B, Li L, Zheng D, Wang J, Hesketh RL, Yang L, Zheng C (2020) Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19). Radiology 295(3):715–721. https://doi.org/10.1148/radiol.2020200370

    Article  PubMed  Google Scholar 

  • Panigada M, Bottino N, Tagliabue P, Grasselli G, Novembrino C, Chantarangkul V, Pesenti A, Peyvandi F, Tripodi A (2020) Hypercoagulability of COVID-19 patients in intensive care unit. A report of thromboelastography findings and other parameters of hemostasis. J Thromb Haemost. https://doi.org/10.1111/jth.14850

  • Pashaei M, Rezaei N (2020) Immunotherapy for SARS-CoV-2: potential opportunities. Expert Opin Biol Ther:1–5. https://doi.org/10.1080/14712598.2020.1807933

  • Phan LT, Nguyen TV, Huynh LKT, Dao MH, Vo TAN, Vu NHP, Pham HTT, Nguyen HT, Nguyen TT, Le HQ, Nguyen TV, Nguyen QH, Huynh TP, Nguyen SN, Nguyen AH, Nguyen NT, Nguyen TNT, Nguyen LT, Luong QC, Cao TM, Pham QD (2020) Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam. J Med Virol. https://doi.org/10.1002/jmv.26075

  • Pourahmad R, Moazzami B, Rezaei N (2020) Efficacy of plasmapheresis and immunoglobulin replacement therapy (IVIG) on patients with COVID-19. SN Comprehensive Clin Med:1–5

    Google Scholar 

  • Qian GQ, Yang NB, Ding F, Ma AHY, Wang ZY, Shen YF, Shi CW, Lian X, Chu JG, Chen L, Wang ZY, Ren DW, Li GX, Chen XQ, Shen HJ, Chen XM (2020) Epidemiologic and clinical characteristics of 91 hospitalized patients with COVID-19 in Zhejiang, China: a retrospective, multi-centre case series. QJM. https://doi.org/10.1093/qjmed/hcaa089

  • Qin C, Liu F, Yen TC, Lan X (2020) 18F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases. Eur J Nucl Med Mol Imaging 47(5):1281–1286. https://doi.org/10.1007/s00259-020-04734-w

    Article  PubMed  CAS  Google Scholar 

  • Rabiee N, Rabiee M, Bagherzadeh M, Rezaei N (2020) COVID-19 and picotechnology: potential opportunities. Med Hypotheses 144:109917. https://doi.org/10.1016/j.mehy.2020.109917

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rezaei N (2020a) COVID-19 affects healthy pediatricians more than pediatric patients. Infect Control Hosp Epidemiol 1. https://doi.org/10.1017/ice.2020.139

  • Rezaei N (2020b) COVID-19 and medical biotechnology. Avicenna J Med Biotechnol 12(3):139

    PubMed  PubMed Central  Google Scholar 

  • Rodriguez-Morales AJ, Cardona-Ospina JA, Gutierrez-Ocampo E, Villamizar-Pena R, Holguin-Rivera Y, Escalera-Antezana JP, Alvarado-Arnez LE, Bonilla-Aldana DK, Franco-Paredes C, Henao-Martinez AF, Paniz-Mondolfi A, Lagos-Grisales GJ, Ramirez-Vallejo E, Suarez JA, Zambrano LI, Villamil-Gomez WE, Balbin-Ramon GJ, Rabaan AA, Harapan H, Dhama K, Nishiura H, Kataoka H, Ahmad T, Sah R (2020) Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis 34:101623. https://doi.org/10.1016/j.tmaid.2020.101623

    Article  PubMed  PubMed Central  Google Scholar 

  • Rokni M, Hamblin MR, Rezaei N (2020) Cytokines and COVID-19: friends or foes? Human Vaccines Immunother:1–3

    Google Scholar 

  • Roland LT, Gurrola JG II, Loftus PA, Cheung SW, Chang JL (2020) Smell and taste symptom-based predictive model for COVID-19 diagnosis. Int Forum Allergy Rhinol. https://doi.org/10.1002/alr.22602

  • Rzymski P, Nowicki M, Mullin GE, Abraham A, Rodríguez-Román E, Petzold MB, Bendau A, Sahu KK, Ather A, Naviaux A-F (2020) Quantity does not equal quality: scientific principles cannot be sacrificed. Int Immunopharmacol 86:106711

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saghazadeh A, Rezaei N (2020a) Immune-epidemiological parameters of the novel coronavirus – a perspective. Expert Rev Clin Immunol 16(5):465–470. https://doi.org/10.1080/1744666x.2020.1750954

  • Saghazadeh A, Rezaei N (2020b) Towards treatment planning of COVID-19: rationale and hypothesis for the use of multiple immunosuppressive agents: anti-antibodies, immunoglobulins, and corticosteroids. Int Immunopharmacol 84:106560. https://doi.org/10.1016/j.intimp.2020.106560

  • Sahu KK, Siddiqui AD, Rezaei N, Cerny J (2020) Challenges for management of immune thrombocytopenia during COVID-19 pandemic. J Med Virol. https://doi.org/10.1002/jmv.26251

  • Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A (2020) Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients. AJR Am J Roentgenol:1–7. https://doi.org/10.2214/ajr.20.23034

  • Saleki K, Banazadeh M, Saghazadeh A, Rezaei N (2020) The involvement of the central nervous system in patients with COVID-19. Rev Neurosci 31(4):453–456. https://doi.org/10.1515/revneuro-2020-0026

    Article  PubMed  CAS  Google Scholar 

  • Scalinci SZ, Trovato Battagliola E (2020) Conjunctivitis can be the only presenting sign and symptom of COVID-19. IDCases 20:e00774. https://doi.org/10.1016/j.idcr.2020.e00774

    Article  PubMed  PubMed Central  Google Scholar 

  • Shamshirian D, Rezaei N (2020) Cardiovascular diseases burden in COVID-19: systematic review and meta-analysis

    Google Scholar 

  • Sharifkashani S, Bafrani MA, Khaboushan AS, Pirzadeh M, Kheirandish A, Yavarpour Bali H, Hessami A, Saghazadeh A, Rezaei N (2020) Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: potential therapeutic targeting. Eur J Pharmacol 884:173455. https://doi.org/10.1016/j.ejphar.2020.173455

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, Fan Y, Zheng C (2020a) Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis 20(4):425–434. https://doi.org/10.1016/s1473-3099(20)30086-4

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Shi S, Qin M, Cai Y, Liu T, Shen B, Yang F, Cao S, Liu X, Xiang Y, Zhao Q, Huang H, Yang B, Huang C (2020b) Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019. Eur Heart J. https://doi.org/10.1093/eurheartj/ehaa408

  • Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, Huang H, Yang B, Huang C (2020c) Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. https://doi.org/10.1001/jamacardio.2020.0950

  • Sodhi CP, Wohlford-Lenane C, Yamaguchi Y, Prindle T, Fulton WB, Wang S, McCray PB Jr, Chappell M, Hackam DJ, Jia H (2018) Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg(9) bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration. Am J Physiol Lung Cell Mol Physiol 314(1):L17–l31. https://doi.org/10.1152/ajplung.00498.2016

    Article  PubMed  CAS  Google Scholar 

  • Sun P, Qie S, Liu Z, Ren J, Li K, Xi J (2020) Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: a single arm meta-analysis. J Med Virol. https://doi.org/10.1002/jmv.25735

  • Suzuki T, Kutsuna S, Nakamura K, Ide S, Moriyama Y, Saito S, Morioka S, Ishikane M, Kinoshita N, Hayakawa K, Ohmagari N (2020) Difficulty of downscaling the precautions for coronavirus disease-19 based on negative throat polymerase chain results in the early phase of infection. J Infect Chemother. https://doi.org/10.1016/j.jiac.2020.05.002

  • Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, Clark C, Iba T (2020) ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost 18(5):1023–1026. https://doi.org/10.1111/jth.14810

    Article  PubMed  CAS  Google Scholar 

  • Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, Chen H, Wang D, Liu N, Liu D, Chen G, Zhang Y, Li D, Li J, Lian H, Niu S, Zhang L, Zhang J (2020) Characteristics of COVID-19 infection in Beijing. J Infect 80(4):401–406. https://doi.org/10.1016/j.jinf.2020.02.018

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, Babudieri S, Petrocelli M, Serra A, Bussu F, Ligas E, Salzano G, De Riu G (2020) Objective evaluation of anosmia and ageusia in COVID-19 patients: single-center experience on 72 cases. Head Neck 42(6):1252–1258. https://doi.org/10.1002/hed.26204

    Article  PubMed  PubMed Central  Google Scholar 

  • Vazquez-Garza E, Jerjes-Sanchez C, Navarrete A, Joya-Harrison J, Rodriguez D (2017) Venous thromboembolism: thrombosis, inflammation, and immunothrombosis for clinicians. J Thromb Thrombolysis 44(3):377–385. https://doi.org/10.1007/s11239-017-1528-7

    Article  PubMed  CAS  Google Scholar 

  • Veeramachaneni GK, Thunuguntla V, Bobbillapati J, Bondili JS (2020) Structural and simulation analysis of hot spot residues interactions of SARS-CoV 2 with human ACE2 receptor. J Biomol Struct Dyn:1–16. https://doi.org/10.1080/07391102.2020.1773318

  • Wan Y, Shang J, Graham R, Baric RS, Li F (2020) Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol 94(7). https://doi.org/10.1128/jvi.00127-20

  • Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z (2020a) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. https://doi.org/10.1001/jama.2020.1585

  • Wang L, He W, Yu X, Hu D, Bao M, Liu H, Zhou J, Jiang H (2020b) Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up. J Infect 80(6):639–645. https://doi.org/10.1016/j.jinf.2020.03.019

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang Y, Dong C, Hu Y, Li C, Ren Q, Zhang X, Shi H, Zhou M (2020c) Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study. Radiology 296:E55–E64. https://doi.org/10.1148/radiol.2020200843

    Article  PubMed  Google Scholar 

  • Weiss SR, Leibowitz JL (2011) Coronavirus pathogenesis. Adv Virus Res 81:85–164. https://doi.org/10.1016/b978-0-12-385885-6.00009-2

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wichmann D, Sperhake JP, Lutgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schroder AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, Puschel K, Kluge S (2020) Autopsy findings and venous thromboembolism in patients with COVID-19. Ann Intern Med doi:https://doi.org/10.7326/m20-2003

  • Woo PC, Lau SK, Chu CM, Chan KH, Tsoi HW, Huang Y, Wong BH, Poon RW, Cai JJ, Luk WK, Poon LL, Wong SS, Guan Y, Peiris JS, Yuen KY (2005) Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol 79(2):884–895. https://doi.org/10.1128/jvi.79.2.884-895.2005

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wu J, Liu J, Zhao X, Liu C, Wang W, Wang D, Xu W, Zhang C, Yu J, Jiang B, Cao H, Li L (2020a) Clinical characteristics of imported cases of COVID-19 in Jiangsu Province: a multicenter descriptive study. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa199

  • Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, Wu K (2020b) Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. https://doi.org/10.1001/jamaophthalmol.2020.1291

  • Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, Li T, Chen Q (2020a) High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 12(1):8. https://doi.org/10.1038/s41368-020-0074-x

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xu J, Wu R, Huang H, Zheng W, Ren X, Wu N, Ji B, Lv Y, Liu Y, Mi R (2020b) Computed tomographic imaging of 3 patients with coronavirus disease 2019 pneumonia with negative virus real-time reverse-transcription polymerase chain reaction test. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa207

  • Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS (2020) Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. https://doi.org/10.1002/alr.22579

  • Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, Dai J, Sun Q, Zhao F, Qu J, Yan F (2020) Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multi-center study in Wenzhou city, Zhejiang, China. J Infect 80(4):388–393. https://doi.org/10.1016/j.jinf.2020.02.016

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yazdanpanah F, Hamblin MR, Rezaei N (2020a) The immune system and COVID-19: friend or foe? Life Sci 256:117900. https://doi.org/10.1016/j.lfs.2020.117900

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yazdanpanah N, Saghazadeh A, Rezaei N (2020b) Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19). Rev Neurosci. https://doi.org/10.1515/revneuro-2020-0039

  • Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM, Lau SK, Anderson DE, Chan KS, Tan TY, Ng TY, Cui L, Said Z, Kurupatham L, Chen MI, Chan M, Vasoo S, Wang LF, Tan BH, Lin RTP, Lee VJM, Leo YS, Lye DC (2020) Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. https://doi.org/10.1001/jama.2020.3204

  • Yousefzadegan S, Rezaei N (2020) Case report: death due to COVID-19 in three brothers. Am J Trop Med Hyg 102(6):1203–1204. https://doi.org/10.4269/ajtmh.20-0240

    Article  PubMed  PubMed Central  Google Scholar 

  • Yu T, Cai S, Zheng Z, Cai X, Liu Y, Yin S, Peng J, Xu X (2020) Association between clinical manifestations and prognosis in patients with COVID-19. Clin Ther. https://doi.org/10.1016/j.clinthera.2020.04.009

  • Zhang J, Wang S, Xue Y (2020a) Fecal specimen diagnosis 2019 novel coronavirus-infected pneumonia. J Med Virol. https://doi.org/10.1002/jmv.25742

  • Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, Akdis CA, Gao YD (2020b) Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. https://doi.org/10.1111/all.14238

  • Zhang L, Zhu F, Xie L, Wang C, Wang J, Chen R, Jia P, Guan HQ, Peng L, Chen Y, Peng P, Zhang P, Chu Q, Shen Q, Wang Y, Xu SY, Zhao JP, Zhou M (2020c) Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann Oncol. https://doi.org/10.1016/j.annonc.2020.03.296

  • Zhang X, Cai H, Hu J, Lian J, Gu J, Zhang S, Ye C, Lu Y, Jin C, Yu G, Jia H, Zhang Y, Sheng J, Li L, Yang Y (2020d) Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings. Int J Infect Dis 94:81–87. https://doi.org/10.1016/j.ijid.2020.03.040

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhao D, Yao F, Wang L, Zheng L, Gao Y, Ye J, Guo F, Zhao H, Gao R (2020) A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa247

  • Zheng F, Tang W, Li H, Huang YX, Xie YL, Zhou ZG (2020) Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. Eur Rev Med Pharmacol Sci 24(6):3404–3410. https://doi.org/10.26355/eurrev_202003_20711

    Article  PubMed  CAS  Google Scholar 

  • Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, Chiu MC, Yang D, Wang Y, Au-Yeung RKH, Chan IH, Sun S, Chan JF, To KK, Memish ZA, Corman VM, Drosten C, Hung IF, Zhou Y, Leung SY, Yuen KY (2017) Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus. Sci Adv 3(11):eaao4966. https://doi.org/10.1126/sciadv.aao4966

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhou Z, Zhao N, Shu Y, Han S, Chen B, Shu X (2020) Effect of gastrointestinal symptoms on patients infected with coronavirus disease 2019. Gastroenterology. https://doi.org/10.1053/j.gastro.2020.03.020

  • Zhu J, Ji P, Pang J, Zhong Z, Li H, He C, Zhang J, Zhao C (2020a) Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis. J Med Virol. https://doi.org/10.1002/jmv.25884

  • Zhu J, Zhong Z, Ji P, Li H, Li B, Pang J, Zhang J, Zhao C (2020b) Clinicopathological characteristics of 8697 patients with COVID-19 in China: a meta-analysis. Fam Med Community Health 8(2). https://doi.org/10.1136/fmch-2020-000406

  • Zhu J, Zhong Z, Li H, Ji P, Pang J, Li B, Zhang J (2020c) CT imaging features of 4121 patients with COVID-19: a meta-analysis. J Med Virol. https://doi.org/10.1002/jmv.25910

  • Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W (2020d) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382(8):727–733. https://doi.org/10.1056/NEJMoa2001017

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhu T, Wang Y, Zhou S, Zhang N, Xia L (2020e) A comparative study of chest computed tomography features in young and older adults with corona virus disease (COVID-19). J Thorac Imaging. https://doi.org/10.1097/rti.0000000000000513

  • Zhu W, Xie K, Lu H, Xu L, Zhou S, Fang S (2020f) Initial clinical features of suspected coronavirus disease 2019 in two emergency departments outside of Hubei, China. J Med Virol. https://doi.org/10.1002/jmv.25763

  • Zumla A, Hui DS, Perlman S (2015) Middle East respiratory syndrome. Lancet 386(9997):995–1007. https://doi.org/10.1016/s0140-6736(15)60454-8

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Mahsa Eskian & Nima Rezaei

  2. Department of Radiology, Center for Evidence-Based Imaging, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Mahsa Eskian

  3. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Mahsa Eskian & Nima Rezaei

  4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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  1. Mahsa Eskian
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  2. Nima Rezaei
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Correspondence to Mahsa Eskian or Nima Rezaei .

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  1. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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Eskian, M., Rezaei, N. (2021). Clinical Manifestations of COVID-19. In: Rezaei, N. (eds) Coronavirus Disease - COVID-19. Advances in Experimental Medicine and Biology, vol 1318. Springer, Cham. https://doi.org/10.1007/978-3-030-63761-3_11

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