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Therapy of Myeloma Bone Disease

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Management of Bone Disease and Kidney Failure in Multiple Myeloma

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Abstract

Bone disease is a cardinal complication of multiple myeloma that affects quality of life and survival. Osteocytes have emerged as key players in the development of myeloma-related bone disease. Along with other factors, they participate in increased osteoclast activity, decreased osteoblast function, and immunosuppressed marrow microenvironment that deregulate bone turnover and result in bone loss and skeletal-related events. Bisphosphonates are the mainstay in the treatment of myeloma bone disease. Denosumab is a novel alternative to bisphosphonates, especially for patients with renal impairment. A deeper understanding of the physiopathology of bone disease will enable the transition of more novel agents from the bench to the bedside.

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Conflict of Interest Disclosure

ET has received honoraria from Amgen, Celgene, Genesis, Janssen, Novartis, BMS, and Takeda; is a member of SC for Amgen and Takeda and a member of IDMC for Celgene; and has received research grants from Amgen, Janssen, and Takeda. INS has no relevant conflict of interest.

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  1. Department of Clinical Therapeutics, Alexandra General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Ioannis Ntanasis-Stathopoulos & Evangelos Terpos

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  1. Ioannis Ntanasis-Stathopoulos
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  2. Evangelos Terpos
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Correspondence to Evangelos Terpos .

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  1. “Seràgnoli” Institute of Hematology, IRCCS, Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy

    Elena Zamagni

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Ntanasis-Stathopoulos, I., Terpos, E. (2021). Therapy of Myeloma Bone Disease. In: Zamagni, E. (eds) Management of Bone Disease and Kidney Failure in Multiple Myeloma. Springer, Cham. https://doi.org/10.1007/978-3-030-63662-3_7

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  • DOI: https://doi.org/10.1007/978-3-030-63662-3_7

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