Nanosystems Comprising Biocompatible Polymers for the Delivery of Photoactive Compounds in Biomedical Applications

Tedesco, Antonio Claudio; Primo, Fernando Lucas; Petrilli, Raquel

doi:10.1007/978-3-030-63389-9_11

Antonio Claudio Tedesco⁵,
Fernando Lucas Primo⁶ &
Raquel Petrilli⁷

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

423 Accesses

Abstract

Biocompatible polymers (BP) have received an increased focus as drug delivery system by providing special characteristics, such as easy design and preparation, different structures, controlled release, stability and protection from enzymatic degradation, allowing the delivery of both hydrophilic and hydrophobic drugs with biodegradability and biocompatibility. Also, they can enhance permeation through physiological barriers and provide targeting to specific tissues. This chapter will present a comprehensive overview of recent advances in the development of these BP biomedical applications as drug delivery systems for photoactive compounds used in the photoprocess to treat cancer or in the photobiomodulation process applicable to regenerative medicine or tissue engineering. The polymers from polylactide, polyglycolide and their copolymers, polydioxanone, polyhydroxybutyrate, alginate, chitosan, collagen and gelatin and their applications with emphasis in the delivery of photoactive compounds will be discussed. The discussion will present pharmacotechnical development, pharmacokinetics and biomedical applications in the field.

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Department of Chemistry, Center of Nanotechnology and Tissue Engineering, Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, 14040-901, Brazil
Antonio Claudio Tedesco
Department of Engineering of Bioprocess and Biotechnology, Faculty of Pharmaceutical Sciences, State São Paulo University—UNESP, Araraquara, São Paulo, Brazil
Fernando Lucas Primo
Institute of Health Sciences, University of International Integration of the Afro-Brazilian Lusophony—UNILAB, Redenção, Ceará, Brazil
Raquel Petrilli

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Faculty of Pharmacy, Odontology and Nursing, Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil
Josimar O. Eloy
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, University of Sao Paulo, Ribeirão Preto, Brazil
Juliana Palma Abriata
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences, University of Sao Paulo, Ribeirão Preto, Brazil
Juliana Maldonado Marchetti

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Tedesco, A.C., Primo, F.L., Petrilli, R. (2021). Nanosystems Comprising Biocompatible Polymers for the Delivery of Photoactive Compounds in Biomedical Applications. In: Eloy, J.O., Abriata, J.P., Marchetti, J.M. (eds) Nanocarriers for Drug Delivery. Nanomedicine and Nanotoxicology. Springer, Cham. https://doi.org/10.1007/978-3-030-63389-9_11

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DOI: https://doi.org/10.1007/978-3-030-63389-9_11
Published: 16 February 2021
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