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Impact of Covid-19 Pandemic on Gastrointestinal Cancer Patients: An Emphasis on Colorectal Cancer

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Colon Cancer Diagnosis and Therapy

Abstract

Gastrointestinal (GI) cancers originate in the GI track, ranging from the esophagus to rectum. Together, these cancers account for a quarter of cancer incidences and more than a third of cancer-related deaths. Of GI cancers, colorectal cancer (CRC) comprises the largest of GI cancer incidence and death burden. Due to the vast array of GI cancers, the survival rate and risk factors vary. The COVID-19 pandemic began in early December 2019 in Wuhan, China. Originally the virus was reported to the World Health Organization as multiple cases of pneumonia. It was later found to be a novel strain of the coronavirus. Since December, there have been more than 28.3 million cases worldwide spread over 214 countries, and this number is consistently increasing. The main method of transmission of COVID-19 is through respiratory droplets, which has made it very difficult to contain. The incidence of COVID-19 is highest among the adult population with the median age of patients between 34 and 59. However, COVID is more likely to affect those with chronic comorbidities and immunosuppression, such as cancer. Due to the novelty of coronavirus and the vagueness of symptoms (cough, congestion, fever, nausea, vomiting), many clinics have stopped doing unnecessary procedures such as endoscopies and colonoscopies. This has led to a decrease in CRC detection and screening. Delayed screenings can be detrimental to the survival of patients with CRC. It has been shown that surgical delays greater than 7–8 weeks have resulted in lower survival rates. It is vital that medical professionals implement safety protocols and provide safe ways for patients to receive routine checkups.

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References

  1. Arnold M, Abnet CC, Neale RE, Vignat J, Giovannucci EL, McGlynn KA, Bray F. Global burden of 5 major types of gastrointestinal cancer. Gastroenterology. 2020 Jul;159(1):335–49 e15. PubMed PMID: 32247694. Epub 2020/04/06.

    PubMed  Google Scholar 

  2. Duarte HO, Gomes J, Machado JC, Reis CA. Gastric cancer: basic aspects. Helicobacter. 2018;23(Suppl 1):e12523. PubMed PMID: 30277636. Epub 2018/10/03.

    Google Scholar 

  3. Greten FR, Weber CK, Greten TF, Schneider G, Wagner M, Adler G, Schmid RM. Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology. 2002;123(6):2052–63. PubMed PMID: 12454861. Epub 2002/11/28.

    Article  CAS  PubMed  Google Scholar 

  4. Jiang K, Al-Diffhala S, Centeno BA. Primary liver cancers-part 1: histopathology, differential diagnoses, and risk stratification. Cancer Control. 2018;25(1):1073274817744625. PubMed PMID: 29350068. PMCID: PMC5933592. Epub 2018/01/20.

    PubMed  PubMed Central  Google Scholar 

  5. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM, Bos JL. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319(9):525–32. PubMed PMID: 2841597. Epub 1988/09/01.

    Article  CAS  PubMed  Google Scholar 

  6. Manton KG, Akushevich I, Kravchenko J. Cancer mortality and morbidity patterns in the U. S. Population an interdisciplinary approach. New York: Springer Nature; 2009.

    Book  Google Scholar 

  7. Arnold M, Soerjomataram I, Ferlay J, Forman D. Global incidence of oesophageal cancer by histological subtype in 2012. Gut. 2015;64(3):381–7. PubMed PMID: 25320104. Epub 2014/10/17.

    Article  PubMed  Google Scholar 

  8. Islami F, Boffetta P, Ren JS, Pedoeim L, Khatib D, Kamangar F. High-temperature beverages and foods and esophageal cancer risk--a systematic review. Int J Cancer. 2009;125(3):491–524. PubMed PMID: 19415743. PMCID: PMC2773211. Epub 2009/05/06.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340(11):825–31. PubMed PMID: 10080844. Epub 1999/03/18.

    Article  CAS  PubMed  Google Scholar 

  10. Green JA, Amaro R, Barkin JS. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. Dig Dis Sci. 2000;45(12):2367–8. PubMed PMID: 11258559. Epub 2001/03/22.

    Article  CAS  PubMed  Google Scholar 

  11. Brown LM, Devesa SS. Epidemiologic trends in esophageal and gastric cancer in the United States. Surg Oncol Clin N Am. 2002;11(2):235–56. PubMed PMID: 12424848. Epub 2002/11/12.

    Article  PubMed  Google Scholar 

  12. Jencks DS, Adam JD, Borum ML, Koh JM, Stephen S, Doman DB. Overview of current concepts in gastric intestinal metaplasia and gastric cancer. Gastroenterol Hepatol (N Y). 2018;14(2):92–101. PMCID: PMC5866308. Epub 2018/04/03.

    Google Scholar 

  13. Correa P, Piazuelo MB. The gastric precancerous cascade. J Dig Dis. 2012;13(1):2–9. PMCID: PMC3404600. Epub 2011/12/23.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Recavarren C, Labow DM, Liang J, Zhang L, Wong M, Zhu H, Wang J, Francis F, Xu R. Histologic characteristics of pancreatic intraepithelial neoplasia associated with different pancreatic lesions. Hum Pathol. 2011;42(1):18–24. PubMed PMID: 21056895. Epub 2010/11/09.

    Article  CAS  PubMed  Google Scholar 

  15. Yadav D, Hawes RH, Brand RE, Anderson MA, Money ME, Banks PA, Bishop MD, Baillie J, Sherman S, DiSario J, Burton FR, Gardner TB, Amann ST, Gelrud A, Lawrence C, Elinoff B, Greer JB, O’Connell M, Barmada MM, Slivka A, Whitcomb DC. North American Pancreatic Study G. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med. 2009;169(11):1035–45. PubMed PMID: 19506173. PMCID: PMC6785300. Epub 2009/06/10.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Villanueva A. Hepatocellular Carcinoma. N Engl J Med. 2019;380(15):1450–62. PubMed PMID: 30970190. Epub 2019/04/11.

    Article  CAS  PubMed  Google Scholar 

  17. Williams JH, Phillips TD, Jolly PE, Stiles JK, Jolly CM, Aggarwal D. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr. 2004;80(5):1106–22. PubMed PMID: 15531656. Epub 2004/11/09.

    Article  CAS  PubMed  Google Scholar 

  18. Khan SA, Thomas HC, Davidson BR, Taylor-Robinson SD. Cholangiocarcinoma. Lancet. 2005;366(9493):1303–14. PubMed PMID: 16214602. Epub 2005/10/11.

    Article  PubMed  Google Scholar 

  19. Broome U, Olsson R, Loof L, Bodemar G, Hultcrantz R, Danielsson A, Prytz H, Sandberg-Gertzen H, Wallerstedt S, Lindberg G. Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis. Gut. 1996;38(4):610–5. PubMed PMID: 8707097. PMCID: PMC1383124. Epub 1996/04/01.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. de Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer. 2017;141(4):664–70. PubMed PMID: 28369882. PMCID: PMC5520228. Epub 2017/04/04.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. Flejou JF. An update on anal neoplasia. Histopathology. 2015;66(1):147–60. PubMed PMID: 25283345. Epub 2014/10/07.

    Article  PubMed  Google Scholar 

  22. Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, Levin TR, Lieberman D, Robertson DJ. Colorectal cancer screening: recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2017;112(7):1016–30. PubMed PMID: 28555630. Epub 2017/05/31.

    Article  PubMed  Google Scholar 

  23. Harapan H, Itoh N, Yufika A, Winardi W, Keam S, Te H, Megawati D, Hayati Z, Wagner AL, Mudatsir M. Coronavirus disease 2019 (COVID-19): a literature review. J Infect Public Health. 2020;13(5):667–73. PubMed PMID: 32340833. PMCID: PMC7142680. Epub 2020/04/29.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol. 2020;92(4):401–2. PubMed PMID: 31950516. PMCID: PMC7166628. Epub 2020/01/18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Saichanapan J, Promsuwan K, Limbut W. Adsorption and determination of sibutramine in illegal slimming product using porous graphene ink-modified electrode. Talanta. 2020;212:120788. PubMed PMID: 32113551. Epub 2020/03/03.

    Article  CAS  PubMed  Google Scholar 

  26. Kramer A, Schwebke I, Kampf G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis. 2006;6:130. PubMed PMID: 16914034. PMCID: PMC1564025. Epub 2006/08/18.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, Wang M. Presumed asymptomatic carrier transmission of COVID-19. JAMA. 2020;323(14):1406–7. PubMed PMID: 32083643. PMCID: PMC7042844. Epub 2020/02/23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–9. PubMed PMID: 32031570. PMCID: PMC7042881. Epub 2020/02/08.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. PubMed PMID: 31986264. PMCID: PMC7159299. Epub 2020/01/28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Chang LM, Wei L, Xie L, Zhu G, Dela Cruz CS, Sharma L. Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China. JAMA. 2020;323(11):1092–3. PubMed PMID: 32031568. PMCID: PMC7042871. Epub 2020/02/08.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Singhal T. A review of coronavirus disease-2019 (COVID-19). Indian J Pediatr. 2020;87(4):281–6. PubMed PMID: 32166607. PMCID: PMC7090728. Epub 2020/03/14.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Fauci AS, Lane HC, Redfield RR. Covid-19 - navigating the uncharted. N Engl J Med. 2020;382(13):1268–9. PubMed PMID: 32109011. PMCID: PMC7121221. Epub 2020/02/29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Liang W, Guan W, Chen R, Wang W, Li J, Xu K, Li C, Ai Q, Lu W, Liang H, Li S, He J. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21(3):335–7. PubMed PMID: 32066541. PMCID: PMC7159000. Epub 2020/02/19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. National University Cancer Institute of Singapore Workflow T. A segregated-team model to maintain cancer care during the COVID-19 outbreak at an academic center in Singapore. Ann Oncol. 2020;31(7):840–3. PubMed PMID: 32243893. PMCID: PMC7174823. Epub 2020/04/04.

    Article  Google Scholar 

  35. Persad G, Phillips J, Emanuel EJ. Allocating medical resources in the time of Covid-19. Reply N Engl J Med. 2020;382(22):e79. PubMed PMID: 32343503. Epub 2020/04/29.

    Article  PubMed  Google Scholar 

  36. Raymond E, Thieblemont C, Alran S, Faivre S. Impact of the COVID-19 outbreak on the management of patients with cancer. Target Oncol. 2020;15(3):249–59. PubMed PMID: 32445083. PMCID: PMC7243433. Epub 2020/05/24.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Ueda M, Martins R, Hendrie PC, McDonnell T, Crews JR, Wong TL, McCreery B, Jagels B, Crane A, Byrd DR, Pergam SA, Davidson NE, Liu C, Stewart FM. Managing Cancer care during the COVID-19 pandemic: agility and collaboration toward a common goal. J Natl Compr Cancer Netw. 2020;20:1–4. PubMed PMID: 32197238. Epub 2020/03/21.

    Google Scholar 

  38. Verma AM, Nagpal JK. Gastrointestinal cancer pathways may breakdown due to COVID-19. Frontline Gastroenterol. 2020;11(5):413. PubMed PMID: 32879723. PMCID: PMC7447284. Epub 2020/09/04.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Maida M. Screening of gastrointestinal cancers during COVID-19: a new emergency. Lancet Oncol. 2020;21(7):e338. PubMed PMID: 32615111. PMCID: PMC7324111. Epub 2020/07/03.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Lee YC, Fann JC, Chiang TH, Chuang SL, Chen SL, Chiu HM, Yen AM, Chiu SY, Hsu CY, Hsu WF, Wu MS, Chen HH. Time to colonoscopy and risk of colorectal cancer in patients with positive results from fecal immunochemical tests. Clin Gastroenterol Hepatol. 2019;17(7):1332–40 e3. PubMed PMID: 30391435. Epub 2018/11/06.

    Article  PubMed  Google Scholar 

  41. Forbes N, Smith ZL, Spitzer RL, Keswani RN, Wani SB, Elmunzer BJ. North American Alliance for the study of digestive manifestations of C. Changes in gastroenterology and endoscopy practices in response to the coronavirus disease 2019 pandemic: results from a North American Survey. Gastroenterology. 2020;159(2):772–4 e13. PubMed PMID: 32376410. PMCID: PMC7196540. Epub 2020/05/08.

    Article  CAS  PubMed  Google Scholar 

  42. Fligor SC, Wang S, Allar BG, Tsikis ST, Ore AS, Whitlock AE, Calvillo-Ortiz R, Arndt KR, Gangadharan SP, Callery MP. Gastrointestinal malignancies and the COVID-19 pandemic: evidence-based triage to surgery. J Gastrointest Surg. 2020;24(10):2357–73. PubMed PMID: 32607860. PMCID: PMC7325836. Epub 2020/07/02.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Kaufman HW, Chen Z, Niles J, Fesko Y. Changes in the number of US patients with newly identified cancer before and during the coronavirus disease 2019 (COVID-19) pandemic. JAMA Netw Open. 2020;3(8):e2017267. PubMed PMID: 32749465. PMCID: PMC7403918. Epub 2020/08/05.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Riyaz Basha .

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Patel, K., Hamby, N., Siraj, S., Kurri, A., Basha, R. (2021). Impact of Covid-19 Pandemic on Gastrointestinal Cancer Patients: An Emphasis on Colorectal Cancer. In: Nagaraju, G.P., Shukla, D., Vishvakarma, N.K. (eds) Colon Cancer Diagnosis and Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-63369-1_3

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