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Orthostatic Hypertension

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Orthostatic Hypotension in Older Adults

Abstract

Orthostatic hypertension is a change in postural blood pressure; its effect and importance are not well-known in older adults. It has been suggested that sympathetic nervous system overexpression and baroreceptor reflex insufficiency might be involved in etiopathogenesis. There are no consensus criteria for the diagnosis of orthostatic hypertension. An increase in systolic blood pressure of 20 mmHg is the most common used criteria when moving from a lying position to a standing position in literature. The frequency of orthostatic hypertension varies according to the diagnostic method and the selected patient group. The clinical significance of orthostatic hypertension remains unclear. However, it has been claimed that there is a cardiovascular risk. It is also thought to be a predictor for cerebrovascular disease. There is no known treatment for orthostatic hypertension; however, non-pharmacological approaches and doxazosin may be effective in treating it. Further studies are needed for the diagnosis and treatment of orthostatic hypertension.

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References

  1. Ricci F, De Caterina R, Fedorowski A. Orthostatic hypotension: epidemiology, prognosis, and treatment. J Am Coll Cardiol. 2015;66(7):848–60.

    Article  Google Scholar 

  2. Kanjwal K, George A, Figueredo VM, Grubb BP. Orthostatic hypotension: definition, diagnosis and management. J Cardiovasc Med (Hagerstown). 2015;16(2):75–81. https://doi.org/10.2459/01.JCM.0000446386.01100.35.

    Article  Google Scholar 

  3. Frith J, Parry SW. New horizons in orthostatic hypotension. Age Ageing. 2017;46(2):168–74. https://doi.org/10.1093/ageing/afw211.

    Article  PubMed  Google Scholar 

  4. Kocyigit SE, Soysal P, Bulut EA, Aydin AE, Dokuzlar O, Isik AT. What is the relationship between frailty and orthostatic hypotension in older adults? J Geriatr Cardiol. 2019;16(3):272–9. https://doi.org/10.11909/j.issn.1671-5411.2019.03.005.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kocyigit SE, Soysal P, Ates Bulut E, Isik AT. Malnutrition and malnutrition risk can be associated with systolic orthostatic hypotension in older adults. J Nutr Health Aging. 2018;22(8):928–33. https://doi.org/10.1007/s12603-018-1032-6.

    Article  CAS  PubMed  Google Scholar 

  6. Magkas N, Tsioufis C, Thomopoulos C, Dilaveris P, Georgiopoulos G, Doumas M, Papadopoulos D, Tousoulis D. Orthostatic hypertension: from pathophysiology to clinical applications and therapeutic considerations. J Clin Hypertens. 2019;21(3):426–33. https://doi.org/10.1111/jch.13491.

    Article  Google Scholar 

  7. Yoshinari M, Wakisaka M, Nakamura U, Yoshioka M, Uchizono Y, Iwase M. Orthostatic hypertension in patients with type 2 diabetes. Diabetes Care. 2001;24(10):1783–6.

    Article  CAS  Google Scholar 

  8. Streeten DH, Auchincloss JH Jr, Anderson GH Jr, Richardson RL, Thomas FD, Miller JW. Orthostatic hypertension. Pathogenetic studies. Hypertension. 1985;7(2):196–203.

    Article  CAS  Google Scholar 

  9. Tabara Y, Igase M, Miki T, Ohyagi Y, Matsuda F, Kohara K, J-SHIPP Study Group. Orthostatic hypertension as a predisposing factor for masked hypertension: the J-SHIPP study. Hypertens Res. 2016;39(9):664–9. https://doi.org/10.1038/hr.2016.43.

    Article  CAS  PubMed  Google Scholar 

  10. Thomas RJ, Liu K, Jacobs DR Jr, Bild DE, Kiefe CI, Hulley SB. Positional change in blood pressure and 8-year risk of hypertension: the CARDIA study. Mayo Clin Proc. 2003;78(8):951–8.

    Article  Google Scholar 

  11. Kario K. Orthostatic hypertension – a new haemodynamic cardiovascular risk factor. Nat Rev Nephrol. 2013;9(12):726–38.

    Article  CAS  Google Scholar 

  12. Brignole M, Moya A, de Lange FJ, et al. 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39(21):1883–948.

    Article  Google Scholar 

  13. Aydin AE, Soysal P, Isik AT. Which is preferable for orthostatic hypotension diagnosis in older adults: active standing test or head-up tilt table test? Clin Interv Aging. 2017;12:207–12. https://doi.org/10.2147/CIA.S129868.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Lee H, Kim HA. Orthostatic hypertension: an underestimated cause of orthostatic intolerance. Clin Neurophysiol. 2016;127(4):2102–7.

    Article  Google Scholar 

  15. Robertson D. Orthostatic hypertension: the last hemodynamic frontier. Hypertension. 2011;57(2):158–9.

    Article  CAS  Google Scholar 

  16. Fessel J, Robertson D. Orthostatic hypertension: when pressor reflexes overcompensate. Nat Clin Pract Nephrol. 2006;2(8):424–31.

    Article  Google Scholar 

  17. Kario K, Shimada K. Risers and extreme-dippers of nocturnal blood pressure in hypertension: antihypertensive strategy for nocturnal blood pressure. Clin Exp Hypertens. 2004;26(2):177–89.

    Article  Google Scholar 

  18. Vriz O, Soon G, Lu H, Weder AB, Canali C, Palatini P. Does ortho-static testing have any role in the evaluation of the young subject with mild hypertension?: an insight from the HARVEST study. Am J Hypertens. 1997;10(5 Pt 1):546–51.

    Article  CAS  Google Scholar 

  19. Benarroch EE. Postural tachycardia syndrome: a heterogeneous and multifactorial disorder. Mayo Clin Proc. 2012;87(12):1214–25.

    Article  Google Scholar 

  20. Low PA, Sandroni P, Joyner M, Shen WK. Postural tachycardia syndrome (POTS). J Cardiovasc Electrophysiol. 2009;20(3):352–8.

    Article  Google Scholar 

  21. Mesquita P, Queiroz D, Lamartine de Lima Silva V, Texeira Vde C, Vilaça de Lima YR, Júnior ER, Garcia J, Bandeira F. Prevalence of orthostatic hypertension in elderly patients with type 2 diabetes. Int J Endocrinol. 2015;2015:463487. https://doi.org/10.1155/2015/463487.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Buddineni JP, Chauhan L, Ahsan ST, Whaley-Connell A. An emerging role for understanding orthostatic hypertension in the cardiorenal syndrome. Cardiorenal Med. 2011;1(2):113–22. https://doi.org/10.1159/000327141.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Barochiner J, Cuffaro PE, Aparicio LS, et al. Predictors of masked hypertension among treated hypertensive patients: an interesting association with orthostatic hypertension. Am J Hypertens. 2013;26(7):872–8.

    Article  CAS  Google Scholar 

  24. Kario K, Eguchi K, Nakagawa Y, Motai K, Shimada K. Relationship between extreme dippers and orthostatic hypertension in elderly hypertensive patients. Hypertension. 1998;31(1):77–82.

    Article  CAS  Google Scholar 

  25. Kario K, Eguchi K, Hoshide S, Hoshide Y, Umeda Y, Mitsuhashi T, Shimada K. U-curve relationship between orthostatic blood pressure change and silent cerebrovascular disease in elderly hypertensives: orthostatic hypertension as a new cardiovascular risk factor. J Am Coll Cardiol. 2002;40(1):133–41.

    Article  Google Scholar 

  26. Weiss A, Beloosesky Y, Grossman A, Shlesinger A, Koren-Morag N, Grossman E. The association between orthostatic hypertension and all- cause mortality in hospitalized elderly persons. J Geriatr Cardiol. 2016;13(3):239–43. https://doi.org/10.11909/j.issn.1671-5411.2016.03.004.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Kostis WJ, Sargsyan D, Mekkaoui C, Moreyra AE, Cabrera J, Cosgrove NM, Sedjro JE, Kostis JB, Cushman WC, Pantazopoulos JS, Pressel SL, Davis BR. Association of orthostatic hypertension with mortality in the Systolic Hypertension in the Elderly Program. J Hum Hypertens. 2019;33(10):735–40. https://doi.org/10.1038/s41371-019-0180-4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Kario K, Matsui Y, Shibasaki S, Eguchi K, Ishikawa J, Hoshide S, Ishikawa S, Kabutoya T, Schwartz JE, Pickering TG, Shimada K, Japan Morning Surge-1 (JMS-1) Study Group. An alpha-adrenergic blocker titrated by self-measured blood pressure recordings lowered blood pressure and microalbuminuria in patients with morning hypertension: the Japan Morning Surge-1 Study. J Hypertens. 2008;26(6):1257–65. https://doi.org/10.1097/HJH.0b013e3282fd173c.

    Article  CAS  PubMed  Google Scholar 

  29. Fedorowski A, Ostling G, Persson M, Struck J, Engström G, Nilsson PM, Hedblad B, Melander O. Orthostatic blood pressure response, carotid intima-media thickness, and plasma fibrinogen in older nondiabetic adults. J Hypertens. 2012;30(3):522–9. https://doi.org/10.1097/HJH.0b013e32834fa860.

    Article  CAS  PubMed  Google Scholar 

  30. Tsukamoto Y, Komuro Y, Akutsu F, et al. Orthostatic hypertension due to coexistence of renal fibromuscular dysplasia and nephroptosis. Jpn Circ J. 1988;52(12):1408–14.

    Article  CAS  Google Scholar 

  31. Curreri C, Giantin V, Veronese N, Trevisan C, Sartori L, Musacchio E, Zambon S, Maggi S, Perissinotto E, Corti MC, Crepaldi G, Manzato E, Sergi G. Orthostatic changes in blood pressure and cognitive status in the elderly: the Progetto Veneto Anziani study. Hypertension. 2016;68(2):427–35. https://doi.org/10.1161/HYPERTENSIONAHA.

    Article  CAS  PubMed  Google Scholar 

  32. Jannetta PJ, Segal R, Wolfson SK Jr. Neurogenic hypertension: etiology and surgical treatment. I. Observations in 53 patients. Ann Surg. 1985;201(3):391–8.

    Article  CAS  Google Scholar 

  33. Hoshide S, Parati G, Matsui Y, Shibazaki S, Eguchi K, Kario K. Orthostatic hypertension: home blood pressure monitoring for detection and assessment of treatment with doxazosin. Hypertens Res. 2012;35(1):100–6.

    Article  CAS  Google Scholar 

  34. Robertson D, Hollister AS, Biaggioni I, Netterville JL, Mosqueda-Garcia R, Robertson RM. The diagnosis and treatment of baroreflex failure. N Engl J Med. 1993;329(20):1449–55.

    Article  CAS  Google Scholar 

  35. Cleophas TJ, Grabowsky I, Niemeyer MG, Mäkel WM, van der Wall EE, Nebivolol Follow-Up Study Group. Paradoxical pressor effects of beta-blockers in standing elderly patients with mild hypertension: a beneficial side effect. Circulation. 2002;105(14):1669–71.

    Article  CAS  Google Scholar 

  36. Suzuki T, Masuda Y, Nonaka M, Kadokura M, Hosoyamada A. Endoscopic thoracic sympathectomy attenuates reflex tachycardia during head-up tilt in lightly anesthetized patients with essential plamar hyperhidrosis. J Anesth. 2002;16(1):4–8.

    Article  Google Scholar 

  37. Jordan J, Shannon JR, Pohar B, Paranjape SY, Robertson D, Robertson RM, Biaggioni I. Contrasting effects of vasodilators on blood pressure and sodium balance in the hypertension of autonomic failure. J Am Soc Nephrol. 1999;10(1):35–42.

    CAS  PubMed  Google Scholar 

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Kocyigit, S.E., Ontan, M.S., Isik, A.T. (2021). Orthostatic Hypertension. In: Isik, A.T., Soysal, P. (eds) Orthostatic Hypotension in Older Adults. Springer, Cham. https://doi.org/10.1007/978-3-030-62493-4_12

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  • DOI: https://doi.org/10.1007/978-3-030-62493-4_12

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