Abstract
The hypothalamus, lying on the central part of the brain, represents an intersection for many nervous pathways. Through the sensory inputs the hypothalamus detects changes in the internal and external environments. All these data put the hypothalamus in a key position to control many bodily functions using three major outputs: the autonomic, endocrine, and behavioural systems. The autonomic control contains hypothalamic neurons projected to the preganglionic neurons of the autonomic system, sympathetic and parasympathetic. The hypothalamo-hypophyseal axis allows the control of the endocrine system. In the relationship with the limbic system, the hypothalamus is involved in emotion control.
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References
Hofman MA, Swaab DF. Neuroplasticity in the human hypothalamus during ageing. NeuroImmune Biol. 2004;4:105–21.
Ciofi P, Garret M, Lapirot O, Lafon P, Loyens A, Prévot V, Levine JE. Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus. Endocrinology. 2009;150(12):5509–19. https://doi.org/10.1210/en.2009-0584.
Truong HQ, Najera E, Zanabria-Ortiz R, Celtikci E, Sun X, Borghei-Razavi H, et al. Surgical anatomy of the superior hypophyseal artery and its relevance for endoscopic endonasal surgery. J Neurosurg. 2018;131(1):154–62. https://doi.org/10.3171/2018.2.JNS172959.
Doglietto F, Prevedello DM, Belotti F, Ferrari M, Lancini D, Schreiber A, et al. The superior hypophyseal arteries: anatomical study with an endoscopic endonasal perspective. Oper Neurosurg (Hagerstown). 2019;17(3):321–31. https://doi.org/10.1093/ons/opy393.
Coote HJ, Spyer KM. Central control of autonomic function. Brain Neurosci Adv. 2018. https://doi.org/10.1177/2398212818812012.
Giuliano F, Allard J. Dopamine and sexual function. Int J Impot Res. 2001;13:S18–28. https://doi.org/10.1038/sj.ijir.3900719.
Argiolas A, Melis MR. Central control of penile erection: role of the paraventricular nucleus of the hypothalamus. Prog Neurobiol. 2005;76(1):1–21. https://doi.org/10.1016/j.pneurobio.2005.06.002.
Parent AD, Perkins E. The hypothalamus. In: Fundamental neuroscience for basic and clinical applications. 5th ed. Philadelphia: Elsevier; 2018.
Coenen VA, Schumacher LV, Kaller C, Schlaepfer TE, Reinacher PC, Egger K, et al. The anatomy of the human medial forebrain bundle: ventral tegmental area connections to reward-associated subcortical and frontal lobe regions. NeuroImage Clin. 2018;18:770–83. https://doi.org/10.1016/j.nicl.2018.03.019.
Wiltshire T, Maixner W, Diatchenko L. Relax, you won’t feel the pain. Nat Neurosci. 2011;14(12):1496–7. https://doi.org/10.1038/nn.2987.
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, et al. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature. 2015;519(7541):45–50. https://doi.org/10.1038/nature14260.
Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol. 2010;72:517–49. https://doi.org/10.1146/annurev-physiol-021909-135821.
MacGregor DJ, Leng G. Modelling the hypothalamic control of growth hormone secretion. J Neuroendocrinol. 2005 Dec;17(12):788-803. doi: 10.1111/j.1365-2826.2005.01370.x. PMID: 16280026.
Moore RY. The suprachiasmatic nucleus and the circadian timing system. Chronobiol Biol Timing Health Dis. 2013:1–28. https://doi.org/10.1016/b978-0-12-396971-2.00001-4.
Hastings MH, Maywood ES, Brancaccio M. Generation of circadian rhythms in the suprachiasmatic nucleus. Nat Rev Neurosci. 2018;19:453–69. https://doi.org/10.1038/s41583-018-0026-z.
Lin K, Yang J, Xu XH, Shen WL. Hypothalamic circuit for thermoregulation. Proc Natl Acad Sci USA. 2017;114(8):2042–7. https://doi.org/10.1073/pnas.1616255114.
Morrison SF. Central control of body temperature. F1000 Research. 2016;5 F1000 Faculty Rev 880. https://doi.org/10.12688/f1000research.7958.1.
Rui L. Brain regulation of energy balance and body weight. Rev Endocr Metab Disord. 2013;14(4):387–407. https://doi.org/10.1007/s11154-013-9261-9.
Matafome P, Seiça R. The role of brain in energy balance. Adv Neurobiol. 2017;19:33–48. https://doi.org/10.1007/978-3-319-63260-5_2.
Taché J. Introduction: Stress as a Cause of Disease. In: Taché J., Selye H., Day S.B. (eds) Cancer, Stress, and Death. Sloan-Kettering Institute Cancer Series. 1978, Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3459-0_1.
Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci. 2006;8(4):383–95.
Trier AM, Mack MR, Kim BS. The neuroimmune axis in skin sensation, inflammation, and immunity. J Immunol. 2019;202(10):2829–35. https://doi.org/10.4049/jimmunol.1801473.
Rajmohan V, Mohandas E. The limbic system. Indian J Psychiatry. 2007;49(2):132–9. https://doi.org/10.4103/0019-5545.33264.
Morgane PJ, Galler JR, Mokler DJ. A review of systems and networks of the limbic forebrain/limbic midbrain. Prog Neurobiol. 2005;75(2):143–60. https://doi.org/10.1016/j.pneurobio.2005.01.001.
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Crivii, C.B., Clichici, S.V., Filip, A.G. (2021). Anatomy and Topography of the Hypothalamus. In: Uwaifo, G.I. (eds) The Human Hypothalamus. Contemporary Endocrinology. Humana, Cham. https://doi.org/10.1007/978-3-030-62187-2_2
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