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Radionuclide Imaging of Inflammatory Vascular Diseases: Vasculitis and Atherosclerosis

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Radionuclide Imaging of Infection and Inflammation

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Abstract

2-[18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) has become part of the worldwide standard of care in oncology. Since a decade, this functional imaging tool has also demonstrated very promising results in inflammatory diseases, especially in large vessel vasculitis and atherosclerosis. Since clinical PET imaging is increasingly used in these two conditions, the aim of this chapter is to assist imaging specialists and clinicians by getting used to the PET imaging procedures and current status in clinical practice for these two vascular inflammatory diseases. General background information, PET technical considerations (including patient’s preparation, imaging protocols, scoring methodology), and diagnostic and prognostic performance, but also response monitoring will be addressed, in the light of recent international expert-based recommendations. Also, in the era of personalized medicine, new hybrid technologies and PET radiotracers are discussed.

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References

  1. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 Revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Arthritis Rheum. 2013;65:1–11.

    Article  CAS  PubMed  Google Scholar 

  2. Spanish GCA Study Group, Italian GCA Study Group, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, Carmona FD, Coit P, et al. Analysis of the common genetic component of large-vessel vasculitides through a meta-immunochip strategy. Sci Rep. 2017;7:43953.

    Article  Google Scholar 

  3. Langford CA, Cuthbertson D, Ytterberg SR, Khalidi N, Monach PA, Carette S, et al. A randomized, double-blind trial of abatacept (CTLA-4Ig) for the treatment of giant cell arteritis. Arthritis Rheumatol. 2017;69:837–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Langford CA, Cuthbertson D, Ytterberg SR, Khalidi N, Monach PA, Carette S, et al. A randomized, double-blind trial of abatacept (CTLA-4Ig) for the treatment of Takayasu arteritis. Arthritis Rheumatol. 2017;69:846–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kubota R, Yamada S, Kubota K, Ishiwata K, Tamahashi N, Ido T. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med. 1992;33:1972–80.

    CAS  PubMed  Google Scholar 

  6. Ninan J, Lester S, Hill C. Giant cell arteritis. Best Pract Res Clin Rheumatol. 2016;30:169–88.

    Article  PubMed  Google Scholar 

  7. de Souza AWS, de Carvalho JF. Diagnostic and classification criteria of Takayasu arteritis. J Autoimmun. 2014;48–49:79–83.

    Article  PubMed  CAS  Google Scholar 

  8. de Boysson H, Liozon E, Ly KH, Dumont A, Delmas C, Aouba A. The different clinical patterns of giant cell arteritis. Clin Exp Rheumatol. 2019;37(Suppl 117):57–60.

    PubMed  Google Scholar 

  9. Weyand CM, Goronzy JJ. Giant-cell arteritis and polymyalgia rheumatica. Solomon CG, editor. N Engl J Med. 2014;371:50–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. de Boysson H, Daumas A, Vautier M, Parienti J-J, Liozon E, Lambert M, et al. Large-vessel involvement and aortic dilation in giant-cell arteritis. A multicenter study of 549 patients. Autoimmun Rev. 2018;17:391–8.

    Article  PubMed  Google Scholar 

  11. Comarmond C, Biard L, Lambert M, Mekinian A, Ferfar Y, Kahn J-E, et al. Long-term outcomes and prognostic factors of complications in Takayasu arteritis: a multicenter study of 318 patients. Circulation. 2017;136:1114–22.

    Article  PubMed  Google Scholar 

  12. Salvarani C, Magnani L, Catanoso M, Pipitone N, Versari A, Dardani L, et al. Tocilizumab: a novel therapy for patients with large-vessel vasculitis. Rheumatology. 2012;51:151–6.

    Article  CAS  PubMed  Google Scholar 

  13. Mekinian A, Comarmond C, Resche-Rigon M, Mirault T, Kahn JE, Lambert M, et al. Efficacy of biological-targeted treatments in Takayasu arteritis: multicenter, retrospective study of 49 patients. Circulation. 2015;132:1693–700.

    Article  CAS  PubMed  Google Scholar 

  14. Bloch DA, Michel BA, Hunder GG, McShane DJ, Arend WP, Calabrese LH, et al. The American College of Rheumatology 1990 criteria for the classification of vasculitis: patients and methods. Arthritis Rheum. 2010;33:1068–73.

    Article  Google Scholar 

  15. Breuer GS, Nesher R, Nesher G. Negative temporal artery biopsies: eventual diagnoses and features of patients with biopsy-negative giant cell arteritis compared to patients without arteritis. Clin Exp Rheumatol. 2008;26:1103–6.

    CAS  PubMed  Google Scholar 

  16. Grossman C, Barshack I, Koren-Morag N, Ben-Zvi I, Bornstein G. Baseline clinical predictors of an ultimate giant cell arteritis diagnosis in patients referred to temporal artery biopsy. Clin Rheumatol. 2016;35:1817–22.

    Article  PubMed  Google Scholar 

  17. Muratore F, Kermani TA, Crowson CS, Green AB, Salvarani C, Matteson EL, et al. Large-vessel giant cell arteritis: a cohort study. Rheumatology. 2015;54:463–70.

    Article  PubMed  Google Scholar 

  18. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324:1029–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Vaidyanathan S, Patel CN, Scarsbrook AF, Chowdhury FU. FDG PET/CT in infection and inflammation—current and emerging clinical applications. Clin Radiol. 2015;70:787–800.

    Article  CAS  PubMed  Google Scholar 

  20. Slart RHJA, Writing Group, Reviewer Group, Members of EANM Cardiovascular, Members of EANM Infection & Inflammation, Members of Committees, SNMMI Cardiovascular, et al. FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC. Eur J Nucl Med Mol Imaging. 2018;45:1250–69.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Nielsen BD, Hansen IT, Kramer S, Haraldsen A, Hjorthaug K, Bogsrud TV, et al. Simple dichotomous assessment of cranial artery inflammation by conventional 18F-FDG PET/CT shows high accuracy for the diagnosis of giant cell arteritis: a case-control study. Eur J Nucl Med Mol Imaging. 2019;46:184–93.

    Article  CAS  PubMed  Google Scholar 

  22. Sammel AM, Hsiao E, Schembri G, Nguyen K, Brewer J, Schrieber L, et al. Diagnostic accuracy of positron emission tomography/computed tomography of the head, neck, and chest for giant cell arteritis: a prospective, double-blind, cross-sectional study. Arthritis Rheumatol. 2019;71:1319–28.

    Article  PubMed  Google Scholar 

  23. Lee YH, Choi SJ, Ji JD, Song GG. Diagnostic accuracy of 18F-FDG PET or PET/CT for large vessel vasculitis: a meta-analysis. Z Rheumatol. 2016;75:924–31.

    Article  CAS  PubMed  Google Scholar 

  24. Besson FL, Parienti J-J, Bienvenu B, Prior JO, Costo S, Bouvard G, et al. Diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2011;38:1764–72.

    Article  PubMed  Google Scholar 

  25. Soussan M, Nicolas P, Schramm C, Katsahian S, Pop G, Fain O, et al. Management of large-vessel vasculitis with FDG-PET: a systematic literature review and meta-analysis. Medicine. 2015;94:e622.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Cheng Y, Lv N, Wang Z, Chen B, Dang A. 18-FDG-PET in assessing disease activity in Takayasu arteritis: a meta-analysis. Clin Exp Rheumatol. 2013;31:S22–7.

    CAS  PubMed  Google Scholar 

  27. Lee S-W, Kim S-J, Seo Y, Jeong SY, Ahn B-C, Lee J. F-18 FDG PET for assessment of disease activity of large vessel vasculitis: a systematic review and meta-analysis. J Nucl Cardiol. 2019;26:59–67.

    Article  PubMed  Google Scholar 

  28. Fuchs M, Briel M, Daikeler T, Walker UA, Rasch H, Berg S, et al. The impact of 18F-FDG PET on the management of patients with suspected large vessel vasculitis. Eur J Nucl Med Mol Imaging. 2012;39:344–53.

    Article  PubMed  Google Scholar 

  29. Duftner C, Dejaco C, Sepriano A, Falzon L, Schmidt WA, Ramiro S. Imaging in diagnosis, outcome prediction and monitoring of large vessel vasculitis: a systematic literature review and meta-analysis informing the EULAR recommendations. RMD Open. 2018;4:e000612.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Dejaco C, Ramiro S, Duftner C, Besson FL, Bley TA, Blockmans D, et al. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice. Ann Rheum Dis. 2018;77:636–43.

    Article  PubMed  Google Scholar 

  31. Daumas A, Rossi P, Bernard-Guervilly F, Francès Y, Berbis J, Durand J-M, et al. Clinical, laboratory, radiological features, and outcome in 26 patients with aortic involvement amongst a case series of 63 patients with giant cell arteritis. Rev Med Interne. 2014;35:4–15.

    Article  CAS  PubMed  Google Scholar 

  32. de Boysson H, Dumont A, Liozon E, Lambert M, Boutemy J, Maigné G, et al. Giant-cell arteritis: concordance study between aortic CT angiography and FDG-PET/CT in detection of large-vessel involvement. Eur J Nucl Med Mol Imaging. 2017;44:2274–9.

    Article  PubMed  CAS  Google Scholar 

  33. Meller J, Strutz F, Siefker U, Scheel A, Sahlmann CO, Lehmann K, et al. Early diagnosis and follow-up of aortitis with [18F]FDG PET and MRI. Eur J Nucl Med Mol Imaging. 2003;30:730–6.

    Article  CAS  PubMed  Google Scholar 

  34. Einspieler I, Thürmel K, Pyka T, Eiber M, Wolfram S, Moog P, et al. Imaging large vessel vasculitis with fully integrated PET/MRI: a pilot study. Eur J Nucl Med Mol Imaging. 2015;42:1012–24.

    Article  CAS  PubMed  Google Scholar 

  35. Nielsen BD, Gormsen LC, Hansen IT, Keller KK, Therkildsen P, Hauge E-M. Three days of high-dose glucocorticoid treatment attenuates large-vessel 18F-FDG uptake in large-vessel giant cell arteritis but with a limited impact on diagnostic accuracy. Eur J Nucl Med Mol Imaging. 2018;45:1119–28.

    Article  CAS  PubMed  Google Scholar 

  36. Blockmans D, de Ceuninck L, Vanderschueren S, Knockaert D, Mortelmans L, Bobbaers H. Repetitive18F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a prospective study of 35 patients. Arthritis Rheum. 2006;55:131–7.

    Article  PubMed  Google Scholar 

  37. Gomez L, Chaumet-Riffaud P, Noel N, Lambotte O, Goujard C, Durand E, et al. Effect of CRP value on 18F–FDG PET vascular positivity in Takayasu arteritis: a systematic review and per-patient based meta-analysis. Eur J Nucl Med Mol Imaging. 2018;45:575–81.

    Article  CAS  PubMed  Google Scholar 

  38. Banerjee S, Quinn KA, Gribbons KB, Rosenblum JS, Civelek AC, Novakovich E, et al. Effect of treatment on imaging, clinical, and serologic assessments of disease activity in large-vessel vasculitis. J Rheumatol. 2020;47:99–107.

    Article  CAS  PubMed  Google Scholar 

  39. Samson M, Devilliers H, Ly KH, Maurier F, Bienvenu B, Terrier B, et al. Tocilizumab as an add-on therapy to glucocorticoids during the first 3 months of treatment of Giant cell arteritis: a prospective study. Eur J Intern Med. 2018;57:96–104.

    Article  CAS  PubMed  Google Scholar 

  40. Dellavedova L, Carletto M, Faggioli P, Sciascera A, Del Sole A, Mazzone A, et al. The prognostic value of baseline 18F-FDG PET/CT in steroid-naïve large-vessel vasculitis: introduction of volume-based parameters. Eur J Nucl Med Mol Imaging. 2016;43:340–8.

    Article  CAS  PubMed  Google Scholar 

  41. Tezuka D, Haraguchi G, Ishihara T, Ohigashi H, Inagaki H, Suzuki J, et al. Role of FDG PET-CT in Takayasu arteritis. JACC Cardiovasc Imaging. 2012;5:422–9.

    Article  PubMed  Google Scholar 

  42. Blockmans D, Coudyzer W, Vanderschueren S, Stroobants S, Loeckx D, Heye S, et al. Relationship between fluorodeoxyglucose uptake in the large vessels and late aortic diameter in giant cell arteritis. Rheumatology. 2008;47:1179–84.

    Article  CAS  PubMed  Google Scholar 

  43. de Boysson H, Liozon E, Lambert M, Parienti J-J, Artigues N, Geffray L, et al. 18F-fluorodeoxyglucose positron emission tomography and the risk of subsequent aortic complications in giant-cell arteritis: a multicenter cohort of 130 patients. Medicine. 2016;95:e3851.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  44. Bergheanu SC, Bodde MC, Jukema JW. Pathophysiology and treatment of atherosclerosis: current view and future perspective on lipoprotein modification treatment. Neth Heart J. 2017;25:231–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Falk E. Pathogenesis of atherosclerosis. J Am Coll Cardiol. 2006;47:C7–12.

    Article  CAS  PubMed  Google Scholar 

  46. Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H. Atherosclerosis: process, indicators, risk factors and new hopes. Int J Prev Med. 2014;5:927–46.

    PubMed  PubMed Central  Google Scholar 

  47. Tahara N, Kai H, Ishibashi M, Nakaura H, Kaida H, Baba K, et al. Simvastatin attenuates plaque inflammation. J Am Coll Cardiol. 2006;48:1825–31.

    Article  CAS  PubMed  Google Scholar 

  48. Marnane M, Prendeville S, McDonnell C, Noone I, Barry M, Crowe M, et al. Plaque inflammation and unstable morphology are associated with early stroke recurrence in symptomatic carotid stenosis. Stroke. 2014;45:801–6.

    Article  CAS  PubMed  Google Scholar 

  49. Carr S, Farb A, Pearce WH, Virmani R, Yao JST. Atherosclerotic plaque rupture in symptomatic carotid artery stenosis. J Vasc Surg. 1996;23:755–66.

    Article  CAS  PubMed  Google Scholar 

  50. Tarkin JM, Joshi FR, Rudd JHF. PET imaging of inflammation in atherosclerosis. Nat Rev Cardiol. 2014;11:443–57.

    Article  CAS  PubMed  Google Scholar 

  51. Tawakol A, Migrino RQ, Bashian GG, Bedri S, Vermylen D, Cury RC, et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol. 2006;48:1818–24.

    Article  PubMed  Google Scholar 

  52. Bucerius J, Duivenvoorden R, Mani V, Moncrieff C, Rudd JHF, Calcagno C, et al. Prevalence and risk factors of carotid vessel wall inflammation in coronary artery disease patients. JACC Cardiovasc Imaging. 2011;4:1195–205.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Ishii H, Nishio M, Takahashi H, Aoyama T, Tanaka M, Toriyama T, et al. Comparison of atorvastatin 5 and 20 mg/d for reducing F-18 fluorodeoxyglucose uptake in atherosclerotic plaques on positron emission tomography/computed tomography: a randomized, investigator-blinded, open-label, 6-month study in Japanese adults scheduled for percutaneous coronary intervention. Clin Ther. 2010;32:2337–47.

    Article  CAS  PubMed  Google Scholar 

  54. On behalf of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM), Bucerius J, Hyafil F, Verberne HJ, Slart RHJA, Lindner O, et al. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis. Eur J Nucl Med Mol Imaging. 2016;43:780–92.

    Article  Google Scholar 

  55. Rudd JHF, Warburton EA, Fryer TD, Jones HA, Clark JC, Antoun N, et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation. 2002;105:2708–11.

    Article  CAS  PubMed  Google Scholar 

  56. Rudd JHF, Myers KS, Bansilal S, Machac J, Rafique A, Farkouh M, et al. 18Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible. J Am Coll Cardiol. 2007;50:892–6.

    Article  PubMed  Google Scholar 

  57. Rudd JHF, Myers KS, Bansilal S, Machac J, Pinto CA, Tong C, et al. Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med. 2008;49:871–8.

    Article  PubMed  Google Scholar 

  58. Kim TN, Kim S, Yang SJ, Yoo HJ, Seo JA, Kim SG, et al. Vascular inflammation in patients with impaired glucose tolerance and type 2 diabetes: analysis with 18F-fluorodeoxyglucose positron emission tomography. Circ Cardiovasc Imaging. 2010;3:142–8.

    Article  PubMed  Google Scholar 

  59. Tahara N, Kai H, Yamagishi S, Mizoguchi M, Nakaura H, Ishibashi M, et al. Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol. 2007;49:1533–9.

    Article  CAS  PubMed  Google Scholar 

  60. Bucerius J, Mani V, Moncrieff C, Rudd JHF, Machac J, Fuster V, et al. Impact of noninsulin-dependent type 2 diabetes on carotid wall 18F-fluorodeoxyglucose positron emission tomography uptake. J Am Coll Cardiol. 2012;59:2080–8.

    Article  PubMed  PubMed Central  Google Scholar 

  61. van der Valk FM, Verweij SL, Zwinderman KAH, Strang AC, Kaiser Y, Marquering HA, et al. Thresholds for arterial wall inflammation quantified by 18F-FDG PET imaging. JACC Cardiovasc Imaging. 2016;9:1198–207.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Rominger A, Saam T, Wolpers S, Cyran CC, Schmidt M, Foerster S, et al. 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease. J Nucl Med. 2009;50:1611–20.

    Article  PubMed  Google Scholar 

  63. Marnane M, Merwick A, Sheehan OC, Hannon N, Foran P, Grant T, et al. Carotid plaque inflammation on 18F-fluorodeoxyglucose positron emission tomography predicts early stroke recurrence. Ann Neurol. 2012;71:709–18.

    Article  PubMed  Google Scholar 

  64. Kelly PJ, Camps-Renom P, Giannotti N, Martí-Fàbregas J, Murphy S, McNulty J, et al. Carotid plaque inflammation imaged by 18F-fluorodeoxyglucose positron emission tomography and risk of early recurrent stroke. Stroke. 2019;50:1766–73.

    Article  CAS  PubMed  Google Scholar 

  65. Figueroa AL, Abdelbaky A, Truong QA, Corsini E, MacNabb MH, Lavender ZR, et al. Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events. JACC Cardiovasc Imaging. 2013;6:1250–9.

    Article  PubMed  Google Scholar 

  66. Moon SH, Cho YS, Noh TS, Choi JY, Kim B-T, Lee K-H. Carotid FDG uptake improves prediction of future cardiovascular events in asymptomatic individuals. JACC Cardiovasc Imaging. 2015;8:949–56.

    Article  PubMed  Google Scholar 

  67. Cho S-G, Park KS, Kim J, Kang S-R, Kwon SY, Seon HJ, et al. Prediction of coronary artery calcium progression by FDG uptake of large arteries in asymptomatic individuals. Eur J Nucl Med Mol Imaging. 2017;44:129–40.

    Article  CAS  PubMed  Google Scholar 

  68. Tawakol A, Fayad ZA, Mogg R, Alon A, Klimas MT, Dansky H, et al. Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation. J Am Coll Cardiol. 2013;62:909–17.

    Article  CAS  PubMed  Google Scholar 

  69. Fayad ZA, Mani V, Woodward M, Kallend D, Abt M, Burgess T, et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial. Lancet. 2011;378:1547–59.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Elkhawad M, Rudd JHF, Sarov-Blat L, Cai G, Wells R, Davies LC, et al. Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis. JACC Cardiovasc Imaging. 2012;5:911–22.

    Article  PubMed  Google Scholar 

  71. Emami H, Vucic E, Subramanian S, Abdelbaky A, Fayad ZA, Du S, et al. The effect of BMS-582949, a P38 mitogen-activated protein kinase (P38 MAPK) inhibitor on arterial inflammation: a multicenter FDG-PET trial. Atherosclerosis. 2015;240:490–6.

    Article  CAS  PubMed  Google Scholar 

  72. Scheen AJ. Cardiovascular effects of gliptins. Nat Rev Cardiol. 2013;10:73–84.

    Article  CAS  PubMed  Google Scholar 

  73. de Boer SA, Heerspink HJL, Lefrandt JD, Hovinga-de Boer MC, van Roon AM, Juárez Orozco LE, et al. Effect of linagliptin on arterial 18F-fluorodeoxyglucose positron emission tomography uptake. J Am Coll Cardiol. 2017;69:1097–8.

    Article  PubMed  CAS  Google Scholar 

  74. Adams RL, Adams IP, Lindow SW, Zhong W, Atkin SL. Somatostatin receptors 2 and 5 are preferentially expressed in proliferating endothelium. Br J Cancer. 2005;92:1493–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Armani C, Catalani E, Balbarini A, Bagnoli P, Cervia D. Expression, pharmacology, and functional role of somatostatin receptor subtypes 1 and 2 in human macrophages. J Leukoc Biol. 2007;81:845–55.

    Article  CAS  PubMed  Google Scholar 

  76. Tarkin JM, Joshi FR, Evans NR, Chowdhury MM, Figg NL, Shah AV, et al. Detection of atherosclerotic inflammation by 68Ga-DOTATATE PET compared to [18F]FDG PET imaging. J Am Coll Cardiol. 2017;69:1774–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Dweck MR, Chow MWL, Joshi NV, Williams MC, Jones C, Fletcher AM, et al. Coronary arterial 18F-sodium fluoride uptake. J Am Coll Cardiol. 2012;59:1539–48.

    Article  CAS  PubMed  Google Scholar 

  78. Dweck MR, Jones C, Joshi NV, Fletcher AM, Richardson H, White A, et al. Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis. Circulation. 2012;125:76–86.

    Article  CAS  PubMed  Google Scholar 

  79. Dweck MR, Khaw HJ, Sng GKZ, Luo ELC, Baird A, Williams MC, et al. Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation? Eur Heart J. 2013;34:1567–74.

    Article  CAS  PubMed  Google Scholar 

  80. Joshi NV, Vesey AT, Williams MC, Shah ASV, Calvert PA, Craighead FHM, et al. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial. Lancet. 2014;383:705–13.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Riemer H. J. A. Slart

  2. Department of Biomedical Photonic Imaging, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands

    Riemer H. J. A. Slart

  3. Department of Biophysics and Nuclear Medicine-Molecular Imaging, Hôpitaux Universitaires Paris-Saclay, Assistance Publique-Hôpitaux de Paris, CHU Bicêtre, Le Kremlin Bicêtre, France

    Florent L. Besson

  4. Université Paris Saclay, CEA, CNRS, Inserm, BioMaps, Orsay, France

    Florent L. Besson

  5. Department of Nuclear Medicine, University Medicine Göttingen, Georg-August-University Göttingen, Göttingen, Germany

    Jan Bucerius

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  1. Riemer H. J. A. Slart
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  2. Florent L. Besson
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  3. Jan Bucerius
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Correspondence to Riemer H. J. A. Slart .

Editor information

Editors and Affiliations

  1. Regional Center of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy

    Elena Lazzeri

  2. Department of Medical-Surgical Sciences and of Translational Medicine, Sapienza University of Rome, Roma, Italy

    Alberto Signore

  3. Department of Translational Research and Advanced Technologies in Medicine and Surgery, Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy

    Paola Anna Erba

  4. Nuclear Medicine Department, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy

    Napoleone Prandini

  5. Nuclear Medicine, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy

    Annibale Versari

  6. Nuclear Medicine Department, Private Hospital “PIO XI”, Roma, Italy

    Giovanni D´Errico

  7. Department of Translational Research and Advanced Technologies in Medicine and Surgery, Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy

    Giuliano Mariani

Glossary

AS

Active segment

CAC

Coronary artery calcium

CETP

Cholesteryl ester transfer protein

cGCA

Cranial giant cell arteritis

CIMT

Carotid intima-media thickness

CT

Computed tomography

CTA

CT angiography

CVA

Cerebrovascular accidents

CVD

Cardiovascular disease

DPP

Dipeptidyl peptidase

[18F]FDG

2-[18F]fluorodeoxyglucose

18F-NaF

Sodium [18F]fluoride

FRS

Framingham risk score

68Ga-DOTATATE

68Ga-DOTA-octreotide

GC

Glucocorticoids

GCA

Giant cell arteritis

HDL-C

High-density lipoprotein cholesterol

LVV

Large vessel vasculitis

lvvGCA

Large vessel vasculitis-giant cell arteritis

MDS

Most diseased segment

MRI

Magnetic resonance imaging

NET

Neuroendocrine tumors

PET

Positron emission tomography

PET/CT

Positron emission tomography/computed tomography

PMR

Polymyalgia rheumatica

SUV

Standardized uptake value

TA

Takayasu arteritis

TBR

Target-to-background ratio

TVS

Total vascular score

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Slart, R.H.J.A., Besson, F.L., Bucerius, J. (2021). Radionuclide Imaging of Inflammatory Vascular Diseases: Vasculitis and Atherosclerosis. In: Lazzeri, E., et al. Radionuclide Imaging of Infection and Inflammation. Springer, Cham. https://doi.org/10.1007/978-3-030-62175-9_15

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  • DOI: https://doi.org/10.1007/978-3-030-62175-9_15

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  • Print ISBN: 978-3-030-62174-2

  • Online ISBN: 978-3-030-62175-9

  • eBook Packages: MedicineMedicine (R0)

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