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Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Venlafaxine, Desvenlafaxine, Duloxetine, Milnacipran, Levomilnacipran

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NeuroPsychopharmacotherapy

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Abstract

Approved members of the selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor (SNRI) class so long are venlafaxine, desvenlafaxine, duloxetine, milnacipran, and levomilnacipran. They differ regarding binding affinity to 5-HT/NE-transporter binding and uptake inhibition, pharmacokinetic properties (half-life, metabolism), and clinical profile (e.g., analgesic properties). Numerous randomized placebo-controlled clinical studies (RCTs) and non-interventional studies have shown efficacy and effectiveness. Some studies reported higher efficacy compared to serotonin selective antidepressants (SSRIs) proposing these drugs for severe and so-called therapy-resistant depressions. Typical side effects are nausea, trouble sleeping, and sexual dysfunction.

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Author information

Authors and Affiliations

  1. Institute of Psychological Medicine (IPM), Soyen, Germany

    Gerd Laux

  2. MVZ Waldkraiburg, Center of Neuropsychiatry, Waldkraiburg, Germany

    Gerd Laux

  3. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany

    Gerd Laux

  4. Vitos Waldkrankenhaus Köppern, Friedrichsdorf, Germany

    Ansgar Klimke

Authors
  1. Gerd Laux
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  2. Ansgar Klimke
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Corresponding author

Correspondence to Gerd Laux .

Editor information

Editors and Affiliations

  1. Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany

    Peter Riederer

  2. Institute of Psychological Medicine (IPM), Soyen, Germany

    Gerd Laux

  3. Centre for Research Promotion and Support, Fujita Health University, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

  4. Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China

    Weidong Le

  5. Würzburg, Germany

    Christian Riederer

Section Editor information

  1. Institute of Psychological Medicine (IPM), Soyen, Germany

    Gerd Laux

  2. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany

    Gerd Laux

  3. Department of Psychiatry, Ludwig-Maximilians-University Munich, Munich, Germany

    Hans-Jürgen Möller

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Laux, G., Klimke, A. (2022). Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Venlafaxine, Desvenlafaxine, Duloxetine, Milnacipran, Levomilnacipran. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-030-62059-2_414

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  • DOI: https://doi.org/10.1007/978-3-030-62059-2_414

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-62058-5

  • Online ISBN: 978-3-030-62059-2

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