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Parkinsonian Drugs: Indications

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NeuroPsychopharmacotherapy

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Abstract

Many substance classes have been introduced for the treatment of motor symptoms in Parkinson’s disease within the last 50 years. The most important and effective medication is still levodopa in combination with a decarboxylase inhibitor. In addition, dopamine agonists, monoamine oxidase B (MAO-B) inhibitors, catechol-o-methyltransferase (COMT) inhibitors, amantadine (N-methyl-d-aspartate-antagonist), and less important anticholinergics are administered depending on the motor symptoms, age, and a multitude of other factors. Fortunately, within the substance classes there are various preparations, which also have different effects. In order that the advantages of the individual medications can be exploited and undesired effects and interactions can be avoided, one must come to terms with the complex data and the pharmacology of the medication. In addition, important aspects are interactions and reciprocal actions. The decision as to which medication to choose must be made individually for each patient.

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Authors and Affiliations

  1. Parkinson-Klinik Ortenau, Wolfach, Germany

    Wolfgang H. Jost

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  1. Wolfgang H. Jost
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Correspondence to Wolfgang H. Jost .

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Editors and Affiliations

  1. Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany

    Peter Riederer

  2. Institute of Psychological Medicine (IPM), Soyen, Germany

    Gerd Laux

  3. Centre for Research Promotion and Support, Fujita Health University, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

  4. Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China

    Weidong Le

  5. WĂĽrzburg, Germany

    Christian Riederer

Section Editor information

  1. Fujita Health University School of Medicine, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

  2. Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan

    Toshiharu Nagatsu

  3. Department of Physiological Chemistry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

    Akira Nakashima

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Jost, W.H. (2022). Parkinsonian Drugs: Indications. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-030-62059-2_216

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  • DOI: https://doi.org/10.1007/978-3-030-62059-2_216

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