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Implications of the Nanoscopic Surface Modification on the Protein Adsorption and Cell Adhesion

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Biobased Nanotechnology for Green Applications

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

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Abstract

Irrespective of the bulk properties of the implant materials, surface properties play a critical role during cell–surface or protein–surface interactions and determine the fate of the implant materials. Physio-chemical properties of surfaces such as surface chemistry, wettability and energy, and surface roughness determine the overall behaviour of the surfaces and can be tailored by various physical, chemical and biochemical surface modification techniques. The present chapter highlights the established understanding of the role of surface properties in regulating protein and cell behaviour at the molecular level. Various biophysical techniques have been described in detail to analyse adsorbed mass, protein conformation, and orientation during protein–surface interactions. We further emphasised on cell adhesion on surfaces that detailed description of integrin mediated cell adhesion. We also tried to establish a synergy how surface modification regulates protein adsorption which in turn governs cell responses on the solid surfaces. The chapter has been designed keeping in mind the young audience especially the beginners in the area of material science and surface engineering.

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  1. Bio-Interface & Environmental Engineering Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Abshar Hasan & Lalit M. Pandey

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  1. Abshar Hasan
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  2. Lalit M. Pandey
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  1. Department of Botany, Nanda Nath Saikia College, Titabar, Jorhat, Assam, India

    Hemen Sarma

  2. Oil & Gas Research Center, Sultan Qaboos University, Muscat, Oman

    Sanket J. Joshi

  3. Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar, India

    Ram Prasad

  4. Department of Analytical Chemistry, Comenius University, Bratislava, Slovakia

    Josef Jampilek

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Hasan, A., Pandey, L.M. (2021). Implications of the Nanoscopic Surface Modification on the Protein Adsorption and Cell Adhesion. In: Sarma, H., Joshi, S.J., Prasad, R., Jampilek, J. (eds) Biobased Nanotechnology for Green Applications. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-61985-5_16

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