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Unraveling Notch Signaling in Reproductive Biology

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Advances in Animal Health, Medicine and Production

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Abstract

Studies over last years have consolidated a relevant role for Notch signaling in mammalian reproductive biology and in reproductive pathological scenarios. Notch genes are dynamically transcribed and Notch proteins dynamically expressed in the reproductive tract. Involvement in key reproductive events is mainly related with the regulation of the pace of cell proliferation and differentiation. Physiologically, this occurs in spermatogenesis, along the epithelial seminiferous cycle, during folliculogenesis and luteal development along the estrous/menstrual cycle, as well as during establishment of pregnancy and placentation. Aberrant Notch signaling has also been associated to genital tract disease, infertility and pregnancy failure. Although insights into the mechanistic action of Notch in these several scenarios have been highlighted, the overall picture of Notch is still fragmentary and elusive. Extensive research being presently conducted may reveal even novel and unsuspected branches into the still highly complex modes of action of this signaling pathway.

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Acknowledgments

Authors’ studies cited in this article were funded by Projects PTDC/CVT/105022/2008, UID/CVT/276/2013 and UIDB/00276/2020 from Foundation for Science and Technology (FCT). Elisabete Silva and Alexandre Trindade are funded by FCT (DL462 57/2016/CP1438/CT0001 and DL 57/2016/CP1438/CT0005, respectively).

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Authors and Affiliations

  1. Reproduction and Development Laboratory, CIISA, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal

    D. Murta, E. Silva, A. Trindade, A. Duarte & L. Lopes-da-Costa

  2. CBIOS, Faculty of Veterinary Medicine, Lusófona University of Humanities and Technologies, Lisbon, Portugal

    D. Murta

  3. Institute for Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal

    D. Henrique

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  1. D. Murta
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  2. E. Silva
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  6. L. Lopes-da-Costa
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Correspondence to L. Lopes-da-Costa .

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  1. Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal

    Antonio Freitas Duarte

  2. Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal

    Luís Lopes da Costa

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Murta, D., Silva, E., Trindade, A., Henrique, D., Duarte, A., Lopes-da-Costa, L. (2020). Unraveling Notch Signaling in Reproductive Biology. In: Freitas Duarte, A., Lopes da Costa, L. (eds) Advances in Animal Health, Medicine and Production . Springer, Cham. https://doi.org/10.1007/978-3-030-61981-7_21

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