Abstract
Percutaneous surgical management including chemodenervation of Trigeminal nerve can be offered to selective patients who have failed medical management. Various agents can be used for this purpose, including alcohol and glycerol. Presented are the indications, procedure techniques, advantages, disadvantages of the procedure when compared to different treatment modalities in the management of trigeminal neuralgia.
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References
Harris W. Three cases of alcohol injection of the gasserian ganglion for trigeminal neuralgia. Proc R Soc Med. 1912;5(clin sect):115–9.
Hakanson S. Trigeminal neuralgia treated by the injection of glycerol into the trigeminal cistern. Neurosurgery. 1981;9:638–46.
Bergenheim A, Hariz M. Influence of previous treatment on outcome after glycerol rhizotomy for trigeminal neuralgia. Neurosurgery. 1995;36(2):303–10.
Kouzounias K, Lind G, Schechtmann G, et al. Comparison of percutaneous balloon compression and glycerol rhizotomy for the treatment of trigeminal neuralgia. J Neurosurg. 2010;113(3):486–92.
Sindou M, Tatli M. Traitement de la névralgie trigéminale par injection de glycérol au niveau du ganglion de Gasser. Neurochirurgie. 2009;55(2):211–2.
Asplund P, Blomstedt P, Bergenheim A. Percutaneous balloon compression vs percutaneous retrogasserian glycerol rhizotomy for the primary treatment of trigeminal neuralgia. Neurosurgery. 2015;78(3):421–8.
Kaplan M, Erol F, Ozveren M, Topsakal C, Sam B, Tekdemir I. Review of complications due to foramen ovale puncture. J Clin Neurosci. 2007;14(6):563–8.
Jho H, Lunsford L. Percutaneous retrogasserian glycerol rhizotomy. Neurosurg Clin N Am. 1997;8(1):63–74.
Eide P, Stubhaug A. Sensory perception in patients with trigeminal neuralgia: effects of percutaneous retrogasserian glycerol rhizotomy. Stereotact Funct Neurosurg. 1997;68(1–4):207–11.
Eide P, Stubhaug A. Relief of trigeminal neuralgia after percutaneous retrogasserian glycerol rhizolysis is dependent on normalization of abnormal temporal summation of pain, without general impairment of sensory perception. Neurosurgery. 1998;43(3):462–72.
Lunsford LD, Bennett MH, Martinez AJ. Experimental trigeminal glycerol injection: electrophysiological and morphological effects. Arch Neurol. 1985;42(2):146–9.
Taylor JJ, Woolsey RM. Dilute ethyl alcohol: effect on the sciatic nerve of the mouse. Arch Phys Med Rehabil. 1976;57:233–7.
Carpenter EB, Seitz DG. Intramuscular alcohol as an aid in management of spastic cerebral palsy. Dev Med Child Neurol. 1980;22:497–501.
Gordon A. Experimental study of intraneural injections of alcohol. J Nerv Ment Dis. 1914;41:81–95.
Zafonte RD, Munin MC. Phenol and alcohol blocks for the treatment of spasticity. Phys Med Rehabil Clin North Am. 2001;12:817–32.
Sweet WH, Poletti CE. Problems with retrogasserian glycerol in the treatment of trigeminal neuralgia. Appl Neurophysiol. 1985;48:252–7.
Bergenheim AT, Hariz MI, Laitinen LV, Olivecrona M, Rabow L. Relation between sensory disturbance and outcome after retrogasserian glycerol rhizotomy. Acta Neurochir. 1991;111:114–8.
King JS, Jewett DL, Sundberg HR. Differential blockade of cat dorsal root C-fibers by various chloride solutions. J Neurosurg. 1972;36:569.
Dulhunty AF, Gage PW. Differential effects of glycerol treatment on membrane capacity and excitation-contraction coupling in toad sartorius fibres. J Physiol. 1973;234(2):373–408.1.
North RB, Kidd DH, Piantadosi S, Carson BS. Percutaneous retrogasserian glycerol rhizotomy. Predictors of success and failure in treatment of trigeminal neuralgia. J Neurosurg. 1990;72:851.
Brashear A, Elovic E, editors. Spasticity, chapter 9. Diagnosis and management. 2nd ed. New York: Demos Medical.
Nathan PW, Sears TA, Smith MC. Effects of phenol solution on the nerve roots of the cat. J Neurol Sci. 1965;2(1):7–29.
Kirvelä O, Svedström E, Lundbom N. Ultrasonic guidance of lumbar sympathetic and celiac plexus block: a new technique. Pain. 1992;17:43–6.
Westerlund T, Vuorinen V, Röyttä M. The effect of combined neurolytic blocking agent 5% phenol-glycerol in rat sciatic nerve. Acta Neuropathol. 2003;106:261–70. https://doi.org/10.1007/s00401-003-0730-1.
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Gargya, A., Abdallah, R.T. (2021). Chemodenervation of Trigeminal Nerve. In: Abd-Elsayed, A. (eds) Trigeminal Nerve Pain. Springer, Cham. https://doi.org/10.1007/978-3-030-60687-9_11
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DOI: https://doi.org/10.1007/978-3-030-60687-9_11
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