Skip to main content
SpringerLink
Log in

Histopathology and Grading of Meningiomas

  • Chapter
  • First Online:
Meningiomas

  • 497 Accesses

Abstract

Meningiomas are the most common primary neoplasm of the central nervous system (CNS). They typically arise from the cranial or spinal meninges and form extra-axial mass lesions, placing them outside the brain or spinal cord parenchyma, but within the confines of the cranium or vertebral column. The classification, grading, and molecular genetic characterization of meningiomas have steadily evolved over the past decades and continue to be revised. Based on the current World Health Organization (WHO) standards for tumor classification, various meningioma subtypes are grouped into three main categories which are centered on biological behavior. These include benign meningiomas (WHO grade I), atypical meningiomas (WHO grade II), and aggressive meningiomas (WHO grade III). This review will focus on the histopathological details of various meningiomas subtypes and how they relate to the contemporary grading schemes provided by the most recent WHO update.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Langford LA. Pathology of meningiomas. J Neuro-Oncol. 1996;29(3):217–21.

    Article  CAS  Google Scholar 

  2. Kepes JJ. Presidential address: the histopathology of meningiomas. A reflection of origins and expected behavior? J Neuropathol Exp Neurol. 1986;45(2):95–107.

    Article  CAS  Google Scholar 

  3. Cyril B, Courville KHA. The histogenesis of meningiomas: with particular reference to the origin of the ‘meningothelial’ variety. J Neuropathol Exp Neurol. 1942;1(3):337–43.

    Article  Google Scholar 

  4. Perry A, Brat DJ. Practical surgical neuropathology: a diagnostic approach. Philadelphia: Churchill Livingstone/Elsevier; 2010.

    Google Scholar 

  5. Lang FF, Macdonald OK, Fuller GN, DeMonte F. Primary extradural meningiomas: a report on nine cases and review of the literature from the era of computerized tomography scanning. J Neurosurg. 2000;93(6):940–50.

    Article  CAS  Google Scholar 

  6. Liu Y, Wang H, Shao H, Wang C. Primary extradural meningiomas in head: a report of 19 cases and review of literature. Int J Clin Exp Pathol. 2015;8(5):5624–32.

    PubMed  PubMed Central  Google Scholar 

  7. Bae SY, Kim HS, Jang HJ, et al. Primary pulmonary chordoid meningioma. Korean J Thorac Cardiovasc Surg. 2018;51(6):410–4.

    Article  Google Scholar 

  8. Luo JZ, Zhan C, Ni X, Shi Y, Wang Q. Primary pulmonary meningioma mimicking lung metastatic tumor: a case report. J Cardiothorac Surg. 2018;13(1):99.

    Article  Google Scholar 

  9. Zulpaite R, Jagelavicius Z, Mickys U, Janilionis R. Primary pulmonary meningioma with rhabdoid features. Int J Surg Pathol. 2019;27(4):457–63.

    Article  Google Scholar 

  10. Alahmadi H, Croul SE. Pathology and genetics of meningiomas. Semin Diagn Pathol. 2011;28(4):314–24.

    Article  Google Scholar 

  11. Louis DN. International Agency for Research on C, Deutsches Krebsforschungszentrum H, Organització Mundial de la S. WHO classification of tumours of the central nervous system. Lyon: International Agency for Research on Cancer; 2016.

    Google Scholar 

  12. Greenfield JG, Love S, Budka H, Ironside JW, Perry A. Greenfield’s neuropathology. Boca Raton: CRC Press; 2015.

    Google Scholar 

  13. Mukhopadhyay M, Das C, Kumari M, Sen A, Mukhopadhyay B, Mukhopadhyay B. Spectrum of meningioma with special reference to prognostic utility of ER, PR and Ki67 expression. J Lab Physicians. 2017;9(4):308–13.

    Article  Google Scholar 

  14. Perry A, Stafford SL, Scheithauer BW, Suman VJ, Lohse CM. The prognostic significance of MIB-1, p53, and DNA flow cytometry in completely resected primary meningiomas. Cancer. 1998;82(11):2262–9.

    Article  CAS  Google Scholar 

  15. Willis J, Smith C, Ironside JW, Erridge S, Whittle IR, Everington D. The accuracy of meningioma grading: a 10-year retrospective audit. Neuropathol Appl Neurobiol. 2005;31(2):141–9.

    Article  CAS  Google Scholar 

  16. Marciscano AE, Stemmer-Rachamimov AO, Niemierko A, et al. Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes. J Neurosurg. 2016;124(1):106–14.

    Article  Google Scholar 

  17. Perry A, Cai DX, Scheithauer BW, et al. Merlin, DAL-1, and progesterone receptor expression in clinicopathologic subsets of meningioma: a correlative immunohistochemical study of 175 cases. J Neuropathol Exp Neurol. 2000;59(10):872–9.

    Article  CAS  Google Scholar 

  18. Roser F, Nakamura M, Bellinzona M, Rosahl SK, Ostertag H, Samii M. The prognostic value of progesterone receptor status in meningiomas. J Clin Pathol. 2004;57(10):1033–7.

    Article  CAS  Google Scholar 

  19. Ironside JW. Diagnostic pathology of nervous system tumours. Edinburgh: Churchill Livingstone; 2002.

    Google Scholar 

  20. Paek SH, Kim SH, Chang KH, et al. Microcystic meningiomas: radiological characteristics of 16 cases. Acta Neurochir. 2005;147(9):965–72; discussion 972.

    Article  CAS  Google Scholar 

  21. Colakoglu N, Demirtas E, Oktar N, Yuntem N, Islekel S, Ozdamar N. Secretory meningiomas. J Neuro-Oncol. 2003;62(3):233–41.

    Article  Google Scholar 

  22. Buhl R, Hugo HH, Mehdorn HM. Brain oedema in secretory meningiomas. J Clin Neurosci. 2001;8(Suppl 1):19–21.

    Article  Google Scholar 

  23. Bruno MC, Ginguene C, Santangelo M, et al. Lymphoplasmacyte rich meningioma. A case report and review of the literature. J Neurosurg Sci. 2004;48(3):117–24; discussion 124.

    CAS  PubMed  Google Scholar 

  24. Champeaux C, Dunn L. World Health Organization grade II meningiomas. Acta Neurochir. 2016;158(5):921–9; discussion 929.

    Article  Google Scholar 

  25. Ng HK, Poon WS, Goh K, Chan MS. Histopathology of post-embolized meningiomas. Am J Surg Pathol. 1996;20(10):1224–30.

    Article  CAS  Google Scholar 

  26. Brokinkel B, Hess K, Mawrin C. Brain invasion in meningiomas-clinical considerations and impact of neuropathological evaluation: a systematic review. Neuro-Oncology. 2017;19(10):1298–307.

    Article  Google Scholar 

  27. Perry A, Stafford SL, Scheithauer BW, Suman VJ, Lohse CM. Meningioma grading: an analysis of histologic parameters. Am J Surg Pathol. 1997;21(12):1455–65.

    Article  CAS  Google Scholar 

  28. Tauziede-Espariat A, Parfait B, Besnard A, et al. Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis. Brain Pathol (Zurich, Switzerland). 2018;28(4):466–74.

    Article  CAS  Google Scholar 

  29. Perry A, Scheithauer BW, Stafford SL, Lohse CM, Wollan PC. “Malignancy” in meningiomas: a clinicopathologic study of 116 patients, with grading implications. Cancer. 1999;85(9):2046–56.

    CAS  PubMed  Google Scholar 

  30. Perry A, Scheithauer BW, Stafford SL, Abell-Aleff PC, Meyer FB. “Rhabdoid” meningioma: an aggressive variant. Am J Surg Pathol. 1998;22(12):1482–90.

    Article  CAS  Google Scholar 

  31. Roncaroli F, Riccioni L, Cerati M, et al. Oncocytic meningioma. Am J Surg Pathol. 1997;21(4):375–82.

    Article  CAS  Google Scholar 

  32. Berho M, Suster S. Mucinous meningioma. Report of an unusual variant of meningioma that may mimic metastatic mucin-producing carcinoma. Am J Surg Pathol. 1994;18(1):100–6.

    Article  CAS  Google Scholar 

  33. Elmaci I, Altinoz MA, Sav A, et al. Whorling-sclerosing meningioma. A review on the histological features of a rare tumor including an illustrative case. Clin Neurol Neurosurg. 2017;162:85–90.

    Article  Google Scholar 

  34. Zheng J, Geng M, Shi Y, Jiang B, Tai Y, Jing H. Oncocytic meningioma: a case report and review of the literature. Surg Oncol. 2013;22(4):256–60.

    Article  CAS  Google Scholar 

  35. Nayak L, Abrey LE, Iwamoto FM. Intracranial dural metastases. Cancer. 2009;115(9):1947–53.

    Article  Google Scholar 

  36. Kleinschmidt-DeMasters BK. Dural metastases. A retrospective surgical and autopsy series. Arch Pathol Lab Med. 2001;125(7):880–7.

    CAS  PubMed  Google Scholar 

  37. Sayegh ET, Burch EA, Henderson GA, Oh T, Bloch O, Parsa AT. Tumor-to-tumor metastasis: breast carcinoma to meningioma. J Clin Neurosci. 2015;22(2):268–74.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Yale New Haven Hospital, New Haven, CT, USA

    Declan McGuone

  2. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Anita Huttner

Authors
  1. Declan McGuone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anita Huttner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anita Huttner .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Yale School of Medicine, Yale New Haven Hospital, New Haven, CT, USA

    Jennifer Moliterno

  2. Department of Neurology, Yale School of Medicine, Yale New Haven Hospital, New Haven, CT, USA

    Antonio Omuro

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

McGuone, D., Huttner, A. (2020). Histopathology and Grading of Meningiomas. In: Moliterno, J., Omuro, A. (eds) Meningiomas. Springer, Cham. https://doi.org/10.1007/978-3-030-59558-6_2

Download citation

Publish with us

Policies and ethics

Search

Navigation