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Acute Kidney Injury and Covid-19: A Scoping Review and Meta-Analysis

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Clinical, Biological and Molecular Aspects of COVID-19

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1321))

Abstract

Acute kidney injury (AKI) is a fatal complication of the new severe acute respiratory syndrome coronavirus (SARS-CoV-2) which causes COVID-19 disease. Here, we performed a scoping review and meta-analysis including clinical studies on patients with SARS-CoV-2 infection with data on AKI assessment and characteristics, and the overall prevalence of AKI was estimated using a random-effects model. We identified 21 articles which passed the search criteria. All were quantitative observational studies which used a cross-sectional, retrospective, case report, or cohort methodology. This showed that aging, diabetes, cardiovascular disease, previous chronic disease, and other comorbidities were risk factors of AKI. Although the prevalence of proteinuria, hematuria, and increased serum creatinine was reported for up to 60% of the patients with COVID-19, the overall prevalence of AKI was estimated to be 8%. We conclude that although approximately two-thirds of patients with COVID-19 had symptoms of kidney damage, most of these did not meet the diagnostic criteria for AKI. Further studies should be performed to validate biomarkers for improved AKI diagnosis in COVID-19 patients and new treatment options are required to reduce the rate of mortality.

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Acknowledgments

Thanks to guidance and advice from the Clinical Research Development Unit of Baqiyatallah Hospital.

Author information

Authors and Affiliations

  1. Trauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Mehdi Jafari-Oori & Amir Vahedian-Azimi

  2. Department of Emergency and Organ Transplantation, Nephrology Dialysis and Transplantation Unit, “Aldo Moro” University, Bari, Italy

    Marco Fiorentino

  3. Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Science, University of Foggia, Foggia, Italy

    Giuseppe Castellano

  4. Behavioral Sciences Research Center, Life style institute, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Abbas Ebadi

  5. Anesthesia and Critical Care Department, Hamadan University of Medical Sciences, Hamadan, Iran

    Farshid Rahimi-Bashar

  6. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

  7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  8. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  9. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

    Amirhossein Sahebkar

  10. Halal Research Center of IRI, FDA, Tehran, Iran

    Amirhossein Sahebkar

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  1. Mehdi Jafari-Oori
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  2. Marco Fiorentino
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  3. Giuseppe Castellano
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  4. Abbas Ebadi
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  5. Farshid Rahimi-Bashar
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  6. Paul C. Guest
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  7. Amir Vahedian-Azimi
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  8. Amirhossein Sahebkar
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Correspondence to Amir Vahedian-Azimi or Amirhossein Sahebkar .

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Editors and Affiliations

  1. University of Campinas, São Paulo, Brazil

    Paul C. Guest

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Jafari-Oori, M. et al. (2021). Acute Kidney Injury and Covid-19: A Scoping Review and Meta-Analysis. In: Guest, P.C. (eds) Clinical, Biological and Molecular Aspects of COVID-19. Advances in Experimental Medicine and Biology(), vol 1321. Springer, Cham. https://doi.org/10.1007/978-3-030-59261-5_28

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