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Importance of Xenobiotic Metabolism: Mechanistic Considerations Relevant for Regulation

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Regulatory Toxicology

Abstract

Most xenobiotic compounds which require regulation undergo metabolic alterations in the human organism which frequently differ from those occurring in nonhuman species and in in vitro experimental test systems. Some of these differences are fundamental, including the complete absence of metabolic steps which are crucial for the toxicity of the compound under consideration. Examples of crucial species differences in toxicity-related xenobiotic metabolism include MeIQx (2-amino-3,8-dimethylimadazo[4,5-f]quinoxaline), aflatoxin B1, and vinyl acetate which are discussed in this chapter.

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Author information

Authors and Affiliations

  1. Institute of Toxicology, Johannes Gutenberg-University, Mainz, Germany

    Franz Oesch

  2. Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Dortmund, Germany

    Jan G. Hengstler

Authors
  1. Franz Oesch
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  2. Jan G. Hengstler
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Correspondence to Franz Oesch .

Editor information

Editors and Affiliations

  1. Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, University Hospital, LMU, München, Germany

    Franz-Xaver Reichl

  2. Formerly: Hannover Medical School, Hannover, Germany

    Michael Schwenk

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Oesch, F., Hengstler, J.G. (2021). Importance of Xenobiotic Metabolism: Mechanistic Considerations Relevant for Regulation. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology . Springer, Cham. https://doi.org/10.1007/978-3-030-57499-4_71

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