Abstract
The concept of nanomaterials that can be designed and administered into the human body to improve health is of great interest. During the past years there has been an increasing amount of research on the uses of nanomaterials in diverse areas of biomedical research including biological sensing, labelling, imaging, cell separation and therapy. In this chapter, the first evaluation of titanate nanotubes (TiONts) as potential carriers of therapeutic molecules is presented. TiONts with controlled parameters have been developed from a hydrothermal synthesis and their biomedical applications have been explored over the last decade. These nanotubes are elaborated as stable suspensions of nanocarriers by surface chemistry engineering. They can be used as transfection agents for cardiomyocytes and we have shown that TiONts can increase the ionizing effect of radiation therapy in the case of glioblastoma. Furthermore, TiONts’ biodistribution has been evaluated by SPECT/CT in male Swiss nude mice and TiONts are quickly cleared. More recently, we have demonstrated that TiONts-docetaxel (DTX) nanohybrids are versatile nanocarriers to limit the systemic toxicity of taxanes and to improve the selectivity of radiotherapy (RT). Our strategy is based on the intraprostatic injection of the TiONts-DTX nanohybrids both in place of brachytherapy and in combination with RT. This is achieved by taking advantage of the TiONts’ morphology as well as their radiosensitization effect and by associating them with docetaxel molecules, also recognized for their radiosensitizing potential. We also grafted the surface of TiONts with gold nanoparticles, for a resulting combined radiosensitizing effect. The elaboration of nanohybrid materials, intended for drug delivery systems and based on TiONts coated with chitosan polymer has also been evaluated. Such nanotubes are combined with transresveratrol derivatives for their anti-oxidizing and antitumor effects. All the aspects of a potential toxicity are also considered.
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References
Agarwal R, Jurney P, Raythatha M et al (2015) Effect of shape, size, and aspect ratio on nanoparticle penetration and distribution inside solid tissues using 3D spheroid models. Adv Healthc Mater 4:2269–2280. https://doi.org/10.1002/adhm.201500441
Albu AM, Draghicescu W, Munteanu T et al (2019) Nitrodopamine vs dopamine as an intermediate layer for bone regeneration applications. Mater Sci Eng C 98:461–471. https://doi.org/10.1016/j.msec.2019.01.014
Alric C, Miladi I, Kryza D et al (2013) The biodistribution of gold nanoparticles designed for renal clearance. Nanoscale 5:5930–5939. https://doi.org/10.1039/c3nr00012e
Amstad E, Gillich T, Bilecka I et al (2009) Ultrastable iron oxide nanoparticle colloidal suspensions using dispersants with catechol-derived anchor groups. Nano Lett 9:4042–4048. https://doi.org/10.1021/nl902212q
Amstad E, Textor M, Reimhult E (2011) Stabilization and functionalization of iron oxide nanoparticles for biomedical applications. Nanoscale 3:2819–2843. https://doi.org/10.1039/c1nr10173k
Amstad E, Gehring AU, Fischer H et al (2011) Influence of electronegative substituents on the binding affinity of catechol-derived anchors to Fe3O4 nanoparticles. J Phys Chem C 115:683–691. https://doi.org/10.1021/jp1109306
Awan UA, Ali S, Rehman M et al (2018) Stable and reproducible synthesis of gold nanorods for biomedical applications: a comprehensive study. IET Nanobiotechnol 12:182–190. https://doi.org/10.1049/iet-nbt.2016.0220
Baati T, Kefi BB, Aouane A et al (2016) Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines. Rsc Adv 6:101688–101696. https://doi.org/10.1039/c6ra24569b
Bahri S, Jonsson CM, Jonsson CL et al (2011) Adsorption and surface complexation study of L-DOPA on rutile (alpha-TiO2) in NaCl solutions. Environ Sci Technol 45:3959–3966. https://doi.org/10.1021/es1042832
Balasundaram G, Sato M, Webster TJ (2006) Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD. Biomaterials 27:2798–2805. https://doi.org/10.1016/j.biomaterials.2005.12.008
Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5:493–506. https://doi.org/10.1038/nrd2060
Bavykin DV, Walsh FC (2009) Elongated titanate nanostructures and their applications. Eur J Inorg Chem 2009:977–997. https://doi.org/10.1002/ejic.200801122
Bavykin DV, Friedrich JM, Walsh FC (2006) Protonated titanates and TiO2 nanostructured materials: synthesis, properties, and applications. Adv Mater 18:2807–2824. https://doi.org/10.1002/adma.200502696
Bellat V, Chassagnon R, Heintz O et al (2015) A multi-step mechanism and integrity of titanate nanoribbons. Dalton Trans 44:1150–1160. https://doi.org/10.1039/c4dt02573c
Benyettou F, Lalatonne Y, Sainte-Catherine O et al (2009) Superparamagnetic nanovector with anti-cancer properties: gamma Fe2O3@Zoledronate. Int J Pharm 379:324–327. https://doi.org/10.1016/j.ijpharm.2009.04.010
Benyettou F, Lalatonne Y, Chebbi I et al (2011) A multimodal magnetic resonance imaging nanoplatform for cancer theranostics. Phys Chem Phys 13:10020–10027. https://doi.org/10.1039/c0cp02034f
Bianco A, Kostarelos K, Prato M (2005) Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol 9:674–679. https://doi.org/10.1016/j.cbpa.2005.10.005
Blanco E, Shen H, Ferrari M (2015) Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol 33:941–951. https://doi.org/10.1038/nbt.3330
Boudon J, Papa A-L, Paris J, Millot N (2014) Titanate nanotubes as a versatile platform for nanomedicine. In: Nanomedicine. One Central Press (OCP), pp 403–428
Bussy C, Al-Jamal KT, Boczkowski J et al (2015) Microglia determine brain region-specific neurotoxic responses to chemically functionalized carbon nano tubes. ACS Nano 9:7815–7830. https://doi.org/10.1021/acsnano.5b02358
Butterworth KT, Nicol JR, Ghita M et al (2016) Preclinical evaluation of gold-DTDTPA nanoparticles as theranostic agents in prostate cancer radiotherapy. Nanomed 11:2035–2047. https://doi.org/10.2217/nnm-2016-0062
Campos CH, Diaz CF, Guzman JL et al (2016) PAMAM-conjugated alumina nanotubes as novel noncytotoxic nanocarriers with enhanced drug loading and releasing performances. Macromol Chem Phys 217:1712–1722. https://doi.org/10.1002/macp.201600136
Cheng YF, Zhang JY, Wang YB et al (2019) Deposition of catechol-functionalized chitosan and silver nanoparticles on biomedical titanium surfaces for antibacterial application. Mater Sci Eng C 98:649–656. https://doi.org/10.1016/j.msec.2019.01.019
Cruje C, Chithrani DB (2014) Polyethylene glycol density and length affects nanoparticle uptake by cancer cells. J Nanomed Res 1 https://doi.org/10.15406/jnmr.2014.01.00006
Daou TJ, Buathong S, Ung D et al (2007) Investigation of the grafting rate of organic molecules on the surface of magnetite nanoparticles as a function of the coupling agent. Sens Act B-Chem 126:159–162. https://doi.org/10.1016/j.snb.2006.11.020
Das R, Alonso J, Nemati Porshokouh Z et al (2016) Tunable high aspect ratio iron oxide nanorods for enhanced hyperthermia. J Phys Chem C 120:10086–10093. https://doi.org/10.1021/acs.jpcc.6b02006
Decuzzi P, Coclite A, Lee A et al (2017) Nano-Particles for biomedical applications. In: Bhushan B (ed) Springer handbook of nanotechnology. Springer, Heidelberg, pp 643–691. https://doi.org/10.1007/978-3-662-54357-3_21
Deng ZJ, Mortimer G, Schiller T et al (2009) Differential plasma protein binding to metal oxide nanoparticles. Nanotechnology 20:455101. https://doi.org/10.1088/0957-4484/20/45/455101
Ernsting MJ, Murakami M, Roy A, Li S-D (2013) Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. J Control Release J Control Release Soc 172:782–794. https://doi.org/10.1016/j.jconrel.2013.09.013
Ge X, Ren C, Lu X et al (2019) Surfactant-free electrochemical synthesis of fluoridated hydroxyapatite nanorods for biomedical applications. Ceram Int 45:17336–17343. https://doi.org/10.1016/j.ceramint.2019.05.292
Gong D, Grimes CA, Varghese OK et al (2001) Titanium oxide nanotube arrays prepared by anodic oxidation. J Mater Res 16:3331–3334. https://doi.org/10.1557/JMR.2001.0457
Gratton SEA, Ropp PA, Pohlhaus PD et al (2008) The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S a 105:11613–11618. https://doi.org/10.1073/pnas.0801763105
Gref R, Luck M, Quellec P et al (2000) “Stealth” corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf B-Biointerfaces 18:301–313. https://doi.org/10.1016/S0927-7765(99)00156-3
Guenin E, Lalatonne Y, Bolley J et al (2014) Catechol versus bisphosphonate ligand exchange at the surface of iron oxide nanoparticles: towards multi-functionalization. J Nanoparticle Res 16:2596. https://doi.org/10.1007/s11051-014-2596-7
Guerrero G, Mutin PH, Vioux A (2001) Anchoring of phosphonate and phosphinate coupling molecules on titania particles. Chem Mater 13:4367–4373. https://doi.org/10.1021/cm001253u
Guerrero G, Alauzun JG, Granier M et al (2013) Phosphonate coupling molecules for the control of surface/interface properties and the synthesis of nanomaterials. Dalton Trans 42:12569–12585. https://doi.org/10.1039/c3dt51193f
Hahm J (2016) Fundamental properties of one-dimensional zinc oxide nanomaterials and implementations in various detection modes of enhanced biosensing. In: Johnson MA, Martinez TJ (eds) Annual review of physical chemistry, vol 67. Annual Reviews, Palo Alto, pp 691–717. https://doi.org/10.1146/annurev-physchem-031215-010949
Howarter JA, Youngblood JP (2006) Optimization of silica silanization by 3-aminopropyltriethoxysilane. Langmuir 22:11142–11147. https://doi.org/10.1021/la061240g
Hung LM, Chen JK, Huang SS et al (2000) Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res 47:549–555. https://doi.org/10.1016/S0008-6363(00)00102-4
Hunton DL, Lucchesi PA, Pang Y et al (2002) Capacitative calcium entry contributes to nuclear factor of activated T-cells nuclear translocation and hypertrophy in cardiomyocytes. J Biol Chem 277:14266–14273. https://doi.org/10.1074/jbc.M107167200
Jeong E, Ul Kim C, Byun J et al (2020) Quantitative evaluation of the antibacterial factors of ZnO nanorod arrays under dark conditions: physical and chemical effects on Escherichia coil inactivation. Sci Total Environ 712:136574. https://doi.org/10.1016/j.scitotenv.2020.136574
Jokerst JV, Lobovkina T, Zare RN, Gambhir SS (2011) Nanoparticle PEGylation for imaging and therapy. Nanomed 6:715–728. https://doi.org/10.2217/nnm.11.19
Kasuga T, Hiramatsu M, Hoson A et al (1998) Formation of titanium oxide nanotube. Langmuir 14:3160–3163. https://doi.org/10.1021/la9713816
Kostarelos K, Lacerda L, Pastorin G et al (2007) Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat Nanotechnol 2:108–113. https://doi.org/10.1038/nnano.2006.209
Lan X, Yin X, Wang R et al (2009) Comparative study of cellular kinetics of reporter probe [131I]FIAU in neonatal cardiac myocytes after transfer of HSV1-tk reporter gene with two vectors. Nucl Med Biol 36:207–213. https://doi.org/10.1016/j.nucmedbio.2008.10.016
Larsen AK, Escargueil AE, Skladanowski A (2000) Resistance mechanisms associated with altered intracellular distribution of anticancer agents. Pharmacol Ther 85:217–229. https://doi.org/10.1016/S0163-7258(99)00073-X
Lee KW, Kim YJ, Kim DO et al (2003) Major phenolics in apple and their contribution to the total antioxidant capacity. J Agric Food Chem 51:6516–6520. https://doi.org/10.1021/jf034475w
Lee N, Hummer DR, Sverjensky DA et al (2012) Speciation of L-DOPA on nanorutile as a function of pH and surface coverage using surface-enhanced Raman spectroscopy (SERS). Langmuir 28:17322–17330. https://doi.org/10.1021/la303607a
Liu Y, Li Y, Li X-M, He T (2013) Kinetics of (3-Aminopropyl)triethoxylsilane (APTES) silanization of superparamagnetic iron oxide nanoparticles. Langmuir 29:15275–15282. https://doi.org/10.1021/la403269u
Loiseau A (2017) Nanotubes de titanate comme nanovecteurs polyvalents : radiosensibilisants du cancer de la prostate et sondes pour l’imagerie nucléaire. Université Bourgogne Franche-Comté, Theses
Loiseau A, Boudon J, Mirjolet C, et al (2017) Taxane-grafted metal-oxide nanoparticles as a new theranostic tool against cancer: the promising example of docetaxel-functionalized titanate nanotubes on prostate tumors. Adv Health Mater 6. https://doi.org/10.1002/adhm.201700245
Loiseau A, Boudon J, Oudot A et al (2019) Titanate nanotubes engineered with gold nanoparticles and docetaxel to enhance radiotherapy on xenografted prostate tumors. Cancers 11:1962. https://doi.org/10.3390/cancers11121962
Loiseau A, Boudon J, Mirjolet C, et al (2021) The influence of the PEGylated length on titanate nanotubes properties and docetaxel nanohybrid cytotoxicity against prostate cancer cells. Molecules submitted
Louch WE, Sheehan KA, Wolska BM (2011) Methods in cardiomyocyte isolation, culture, and gene transfer. J Mol Cell Cardiol 51:288–298. https://doi.org/10.1016/j.yjmcc.2011.06.012
Lu Z, Cheng B, Hu Y et al (2009) Complexation of resveratrol with cyclodextrins: solubility and antioxidant activity. Food Chem 113:17–20. https://doi.org/10.1016/j.foodchem.2008.04.042
Ma H, Tarr J, DeCoster MA et al (2009) Synthesis of magnetic porous hollow silica nanotubes for drug delivery. J Appl Phys 105:07B309. https://doi.org/10.1063/1.3072048
Maezawa H, Furusawa Y, Kobayashi K et al (1996) Lethal effect of K-shell absorption of intracellular phosphorus on wild-type and radiation sensitive mutants of Escherichia coli. Acta Oncol 35:889–894. https://doi.org/10.3109/02841869609104042
Magrez A, Horváth L, Smajda R et al (2009) Cellular toxicity of TiO2-based nanofilaments. ACS Nano 3:2274–2280. https://doi.org/10.1021/nn9002067
Maurizi L, Papa A-L, Dumont L et al (2015) Influence of surface charge and polymer coating on internalization and biodistribution of polyethylene glycol-modified iron oxide nanoparticles. J Biomed Nanotechnol 11:126–136. https://doi.org/10.1166/jbn.2015.1996
Maurizi L, Papa A-L, Boudon J et al (2018) Toxicological risk assessment of emerging nanomaterials: cytotoxicity, cellular uptake, effects on biogenesis and cell organelle activity, acute toxicity and biodistribution of oxide nanoparticles. In: Gomes AC, Sarria MP (eds) Unraveling the safety profile of nanoscale particles and materials - from biomedical to environmental applications. InTech, Rijeka, pp 17–36. https://doi.org/10.5772/intechopen.71833
Miladi I, Alric C, Dufort S et al (2014) The in vivo radiosensitizing effect of gold nanoparticles based MRI contrast agents. Small 10:1116–1124. https://doi.org/10.1002/smll.201302303
Mirjolet C, Papa AL, Créhange G et al (2013) The radiosensitization effect of titanate nanotubes as a new tool in radiation therapy for glioblastoma: a proof-of-concept. Radiother Oncol J Eur Soc Ther Radiol Oncol. https://doi.org/10.1016/j.radonc.2013.04.004
Mirjolet C, Boudon J, Loiseau A et al (2017) Docetaxel-titanate nanotubes enhance radiosensitivity in an androgen-independent prostate cancer model. Int J Nanomedicine 12:6357–6364. https://doi.org/10.2147/IJN.S139167
Mohammadi F, Moeeni M, Li C et al (2020) Interaction of cellulose and nitrodopamine coated superparamagnetic iron oxide nanoparticles with alpha-lactalbumin. RSC Adv 10:9704–9716. https://doi.org/10.1039/C9RA09045B
Mosqueira VCF, Legrand P, Morgat JL et al (2001) Biodistribution of long-circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density. Pharm Res 18:1411–1419. https://doi.org/10.1023/A:1012248721523
Motte L, Benyettou F, de Beaucorps C et al (2011) Multimodal superparamagnetic nanoplatform for clinical applications: immunoassays, imaging & therapy. Faraday Discuss 149:211–225. https://doi.org/10.1039/c005286h
Mutin PH, Guerrero G, Vioux A (2005) Hybrid materials from organophosphorus coupling molecules. J Mater Chem 15:3761–3768. https://doi.org/10.1039/b505422b
Nel AE, Mädler L, Velegol D et al (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543–557. https://doi.org/10.1038/nmat2442
Niu L, Shao M, Wang S et al (2008) Titanate nanotubes: preparation, characterization, and application in the detection of dopamine. J Mater Sci 43:1510–1514. https://doi.org/10.1007/s10853-007-2374-3
Papa A-L, Millot N, Saviot L et al (2009) Effect of reaction parameters on composition and morphology of titanate nanomaterials. J Phys Chem C 113:12682–12689. https://doi.org/10.1021/jp903195h
Papa A-L, Maurizi L, Vandroux D et al (2011) Synthesis of titanate nanotubes directly coated with USPIO in hydrothermal conditions: a new detectable nanocarrier. J Phys Chem C 115:19012–19017. https://doi.org/10.1021/jp2056893
Papa A-L, Dumont L, Vandroux D, Millot N (2013) Titanate nanotubes: towards a novel and safer nanovector for cardiomyocytes. Nanotoxicology 7:1131–1142. https://doi.org/10.3109/17435390.2012.710661
Papa A-L, Boudon J, Bellat V et al (2015) Dispersion of titanate nanotubes for nanomedicine: comparison of PEI and PEG nanohybrids. Dalton Trans Camb Engl 44:739–746. https://doi.org/10.1039/c4dt02552k
Parhi P, Mohanty C, Sahoo SK (2012) Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy. Drug Discov Today 17:1044–1052. https://doi.org/10.1016/j.drudis.2012.05.010
Paris J, Bernhard Y, Boudon J et al (2015) Phthalocyanine-titanate nanotubes: a promising nanocarrier detectable by optical imaging in the so-called imaging window. RSC Adv 5:6315–6322. https://doi.org/10.1039/c4ra13988g
Patil N, Jérôme C, Detrembleur C (2018) Recent advances in the synthesis of catechol-derived (bio)polymers for applications in energy storage and environment. Prog Polym Sci 82:34–91. https://doi.org/10.1016/j.progpolymsci.2018.04.002
Pirola L, Froejdoe S (2008) Resveratrol: one molecule, many targets. IUBMB Life 60:323–332. https://doi.org/10.1002/iub.47
Pontón PI, d’Almeida JRM, Marinkovic BA et al (2014) The effects of the chemical composition of titanate nanotubes and solvent type on 3-aminopropyltriethoxysilane grafting efficiency. Appl Surf Sci 301:315–322. https://doi.org/10.1016/j.apsusc.2014.02.071
Pujari SP, Scheres L, Marcelis ATM, Zuilhof H (2014) Covalent surface modification of oxide surfaces. Angew Chem-Int Ed 53:6322–6356. https://doi.org/10.1002/anie.201306709
Raffa V, Ciofani G, Vittorio O et al (2009) Physicochemical properties affecting cellular uptake of carbon nanotubes. Nanomed 5:89–97. https://doi.org/10.2217/nnm.09.95
Ries H, Cook H (1954) Monomolecular films of mixtures. 1. stearic acid with isostearic acid and with tri-para-cresyl phosphate - comparison of components with octadecylphosphonic acid and with tri-ortho-xenyl phosphate. J Colloid Sci 9:535–546. https://doi.org/10.1016/0095-8522(54)90056-2
Rizzo LY, Golombek SK, Mertens ME, et al (2013) In vivo nanotoxicity testing using the Zebrafish Embryo Assay. J Mater Chem B Mater Biol Med 1. https://doi.org/10.1039/C3TB20528B
Saiz-Poseu J, Mancebo-Aracil J, Nador F et al (2019) The chemistry behind catechol-based adhesion. Angew Chem Int Ed 58:696–714. https://doi.org/10.1002/anie.201801063
Sallem F (2017) Optimized syntheses and advanced characterizations of titanate nanotubes and their functionalization : towards the development of nanovectors of therapeutic molecules. Université Bourgogne Franche-Comté, Theses
Sallem F, Chassagnon R, Megriche A et al (2017) Effect of mechanical stirring and temperature on dynamic hydrothermal synthesis of titanate nanotubes. J Alloys Compd 722:785–796. https://doi.org/10.1016/j.jallcom.2017.06.172
Sallem F, Boudon J, Heintz O et al (2017) Synthesis and characterization of chitosan-coated titanate nanotubes: towards a new safe nanocarrier. Dalton Trans. https://doi.org/10.1039/C7DT03029K
Schuemann J, Berbeco R, Chithrani DB et al (2016) Roadmap to clinical use of gold nanoparticles for radiation sensitization. Int J Radiat Oncol Biol Phys 94:189–205. https://doi.org/10.1016/j.ijrobp.2015.09.032
Singh N, Millot N, Maurizi L et al (2020) Taurine-conjugated mussel-inspired iron oxide nanoparticles with an elongated shape for effective delivery of doxorubicin into the tumor cells. ACS Omega 5:16165–16175. https://doi.org/10.1021/acsomega.0c01747
Sruthi S, Loiseau A, Boudon J et al (2018) In vitro interaction and biocompatibility of titanate nanotubes with microglial cells. Toxicol Appl Pharmacol 353:74–86. https://doi.org/10.1016/j.taap.2018.06.013
Suganya TR, Devasena T (2015) Exploring the mechanism of anti-inflammatory activity of phyto-stabilized silver nanorods. Dig J Nanomater Biostructures 10:277–282
Sun X, Li Y (2003) Synthesis and characterization of ion-exchangeable titanate nanotubes. Chem Eur J 9:2229–2238. https://doi.org/10.1002/chem.200204394
Sun N, Li X, Wang Z et al (2016) A multiscale TiO2 nanorod array for ultrasensitive capture of circulating tumor cells. ACS Appl Mater Interfaces 8:12638–12643. https://doi.org/10.1021/acsami.6b02178
Takakura K (1996) Double-strand breaks in DNA induced by the K-shell ionization of calcium atoms. Acta Oncol 35:883–888. https://doi.org/10.3109/02841869609104041
Thapa B, Diaz-Diestra D, Santiago-Medina C et al (2018) T1- and T2-weighted magnetic resonance dual contrast by single core truncated cubic iron oxide nanoparticles with abrupt cellular internalization and immune evasion. ACS Appl Bio Mater 1:79–89. https://doi.org/10.1021/acsabm.8b00016
Thomas G, Demoisson F, Heintz O et al (2015) Functionalized Fe3O4 nanoparticles: influence of ligand addition sequence and pH during their continuous hydrothermal synthesis. RSC Adv 5:78614–78624. https://doi.org/10.1039/C5RA17452J
Thomas G, Demoisson F, Boudon J, Millot N (2016) Efficient functionalization of magnetite nanoparticles with phosphonate using a one-step continuous hydrothermal process. Dalton Trans 45:10821–10829. https://doi.org/10.1039/C6DT01050D
Togashi T, Takami S, Kawakami K et al (2012) Continuous hydrothermal synthesis of 3,4-dihydroxyhydrocinnamic acid-modified magnetite nanoparticles with stealth-functionality against immunological response. J Mater Chem 22:9041–9045. https://doi.org/10.1039/c2jm30325f
Wang X, Shao M, Zhang S, Liu X (2013) Biomedical applications of gold nanorod-based multifunctional nano-carriers. J Nanoparticle Res 15:1892. https://doi.org/10.1007/s11051-013-1892-y
White LD, Tripp CP (2000) Reaction of (3-aminopropyl)dimethylethoxysilane with amine catalysts on silica surfaces. J Colloid Interface Sci 232:400–407. https://doi.org/10.1006/jcis.2000.7224
Wu B, Zhang L-J, Zhang C-J et al (2020) Effect of Poly(ethylene glycol) (PEG) surface density on the fate and antitumor efficacy of redox-sensitive hybrid nanoparticles. ACS Biomater Sci Eng 6:3975–3983. https://doi.org/10.1021/acsbiomaterials.0c00516
Xiao J, Song J, Hodara V et al (2013) Protective effects of resveratrol on TNF-alpha-induced endothelial cytotoxicity in baboon femoral arterial endothelial cells. J Diabet Res UNSP 185172. https://doi.org/10.1155/2013/185172
Acknowledgements
JB, AL, FS, LM and NM acknowledge the funding support from French Government through the CNRS, the “Université de Bourgogne”, the “Conseil Régional Bourgogne Franche-Comté, the European Union (PO FEDER-FSE Bourgogne 2014/2020 programs), the Cancéropôle Est and the EIPHI Graduate School (ANR-17-EURE-0002). ALP acknowledges the support from the George Washington University start-up funds. All the people who contributed in the results presented in this chapter are greatly acknowledged: Sudhakaran Sruthi, Gérard Lizard, Thomas Courant, Johanna Chluba, Laurence Motte, Erwan Guénin, Frédéric Geinguenaud, Laure Dumond, David Vandroux, Céline Mirjolet, Véronique Morgand, Olivier Heintz and Rémi Chassagnon, as well as all the people from the PharmImage® consortium, the 3MIM agreement and the IMAPPI program who are involved but not mentioned in the presented results.
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Boudon, J., Sallem, F., Loiseau, A., Maurizi, L., Papa, AL., Millot, N. (2021). Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications. In: J.M. Abadie, M., Pinteala, M., Rotaru, A. (eds) New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-57456-7_8
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