Abstract
Underactive bladder (UAB) is defined as “a symptom complex suggestive of detrusor underactivity and is usually characterized by prolonged urination time with or without a sensation of incomplete bladder emptying, usually with hesitancy, reduced sensation on filling, slow stream, palpable bladder, always straining to void, enuresis, and/or stress incontinence”. Detrusor underactivity (DUA) is the physio-pathological background of UAB and it is defined by the International Continence Society (ICS) as “a contraction of reduced strength and/or duration, resulting in prolonged bladder emptying and/or failure to achieve complete bladder emptying within a normal time span”. Any alteration of the anatomical structures involved in the bladder physiology can impair the detrusor function and load underactive bladder. Particularly, neurological, metabolic, and functional diseases may cause specific neurological and muscle alterations implicated in the UB physiopathology. When the cause is not clear, UAB can be defined “idiopathic”.
The better understanding of physiopathology of underactive bladder and detrusor underactivity has a pivotal role in their diagnosis and treatment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aldamanhori R, Osman NI, Chapple CR. Underactive bladder: pathophysiology and clinical significance. Asian J Urol. 2018;5(1):17–21.
Artibani W, Cerruto MA. Dysfunctional voiding. Curr Opin Urol. 2014;24(4):330–5.
Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology of lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Neurourol Urodyn. 2002;21(2):167–78.
Chapple CR, Osman NI, Birder L, van Koeveringe GA, Oelke M, Nitti VW, et al. The underactive bladder: a new clinical concept? Eur Urol. 2015;68(3):351–3.
Dewulf K, Abraham N, Lamb LE, Griebling TL, Yoshimura N, Tyagi P, et al. Addressing challenges in underactive bladder: recommendations and insights from the Congress on Underactive Bladder (CURE-UAB). Int Urol Nephrol. 2017;49(5):777–85.
Yu YD, Jeong SJ. Epidemiology of underactive bladder: common but underresearched. Invest Clin Urol. 2017;58(Suppl 2):S68–74.
Sexton CC, Coyne KS, Kopp ZS, Irwin DE, Milsom I, Aiyer LP, et al. The overlap of storage, voiding and postmicturition symptoms and implications for treatment seeking in the USA, UK and Sweden: EpiLUTS. BJU Int. 2009;103:12–23.
Smith PP. Pathophysiology of the underactive bladder: evolving new concepts. Curr Bladder Dysfunct Rep. 2017;12(1):35–41.
Elbadawi A, Hailemariam S, Yalla SV, Resnick NM. Structural basis of geriatric voiding dysfunction. VII. Prospective ultrastructural/urodynamic evaluation of its natural evolution. J Urol. 1997;157(5):1814–22.
Osman NI, Chapple CR. Contemporary concepts in the aetiopathogenesis of detrusor underactivity. Nat Rev Urol. 2014;11(11):639.
Brierly R, Hindley R, McLarty E, Harding D, Thomas P. A prospective controlled quantitative study of ultrastructural changes in the underactive detrusor. J Urol. 2003;169(4):1374–8.
Osman N, Mangera A, Hillary C, Inman R, Chapple C. The underactive bladder: detection and diagnosis. F1000Res. 2016;5.
Daneshgari F, Liu G, Birder L, Hanna-Mitchell AT, Chacko S. Diabetic bladder dysfunction: current translational knowledge. J Urol. 2009;182(6S):S18–26.
Galì A, Mucciardi G, Buttice S, Subba E, D’Amico C, Lembo F, et al. Correlation between advanced glycation end-products, lower urinary tract symptoms and bladder dysfunctions in patients with type 2 diabetes mellitus. Low Urin Tract Symptoms. 2017;9(1):15–20.
Ramakrishnan VM, Eswara JR. Basic bladder physiology and anatomy. In: Stoffel JT, Dray EV, editors. Urological care for patients with progressive neurological conditions. Cham: Springer; 2020. p. 7–15.
Osman NI, Esperto F, Chapple CR. Detrusor underactivity and the underactive bladder: a systematic review of preclinical and clinical studies. Eur Urol. 2018;74(5):633–43.
Baldini G, Bagry H, Aprikian A, Carli F. Postoperative urinary retention: anesthetic and perioperative considerations. Anesthesiology. 2009;110(5):1139–57.
Cucchi A, Quaglini S, Rovereto B. Development of idiopathic detrusor underactivity in women: from isolated decrease in contraction velocity to obvious impairment of voiding function. Urology. 2008;71(5):844–8.
Cucchi A, Quaglini S, Guarnaschelli C, Rovereto B. Urodynamic findings suggesting two-stage development of idiopathic detrusor underactivity in adult men. Urology. 2007;70(1):75–9.
Taylor JA III, Kuchel GA. Detrusor underactivity: clinical features and pathogenesis of an underdiagnosed geriatric condition. J Am Geriatr Soc. 2006;54(12):1920–32.
Smith PP. Aging and the underactive detrusor: a failure of activity or activation? Neurourol Urodyn. 2010;29(3):408–12.
Osman NI, Chapple CR. Fowler’s syndrome—a cause of unexplained urinary retention in young women? Nat Rev Urol. 2014;11(2):87.
Dasgupta R, Critchley HD, Dolan RJ, Fowler CJ. Changes in brain activity following sacral neuromodulation for urinary retention. J Urol. 2005;174(6):2268–72.
Groutz A, Blaivas JG, Pies C, Sassone AM. Learned voiding dysfunction (non-neurogenic, neurogenic bladder) among adults. Neurourol Urodyn. 2001;20(3):259–68.
Choi YS, Kim JC, Lee KS, Seo JT, Kim H-J, Yoo TK, et al. Analysis of female voiding dysfunction: a prospective, multi-center study. Int Urol Nephrol. 2013;45(4):989–94.
Sinha S. Dysfunctional voiding: a review of the terminology, presentation, evaluation and management in children and adults. Indian J Urol. 2011;27(4):437–47.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Cerruto, M.A., Tafuri, A. (2021). Physiopathology of Underactive Bladder. In: Balzarro, M., Li Marzi, V. (eds) Non-Neurogenic Bladder Dysfunctions. Urodynamics, Neurourology and Pelvic Floor Dysfunctions. Springer, Cham. https://doi.org/10.1007/978-3-030-57393-5_8
Download citation
DOI: https://doi.org/10.1007/978-3-030-57393-5_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-57392-8
Online ISBN: 978-3-030-57393-5
eBook Packages: MedicineMedicine (R0)