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Antimicrobial Stewardship

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Infection Management in Hematology

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

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Abstract

Antimicrobial stewardship programs are becoming more common, but the experience specifically in hematologic neutropenic patients is scarce. Concerns about poor outcomes due to immune deficiency, and lack of specific data have prevented so far a comprehensive implementation of antimicrobial stewardship in this population. Neutropenia is the most important risk factor for infection and the most frequent reason for broad-spectrum antimicrobial long-term use in hematologic malignancy patients. Infections caused by multidrug-resistant (MDR) microorganisms are a relevant issue in this scenario. In the ever-growing emergence of multidrug-resistant microorganisms which hampers the early administration of targeted small spectrum therapy, antimicrobial stewardship is becoming an urgent necessity. Limited but increasing favorable data show that application of antimicrobial stewardship principles to immunocompromised hosts is feasible.

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References

  • Abbo LM, Ariza-Heredia EJ (2014) Antimicrobial stewardship in immunocompromised hosts. Infect Dis Clin N Am 28(2):263–279. https://doi.org/10.1016/j.idc.2014.01.008

    Article  Google Scholar 

  • Aguilar-Guisado M, Espigado I, Cordero E, Noguer M, Parody R, Pachon J, Cisneros JM (2010) Empirical antifungal therapy in selected patients with persistent febrile neutropenia. Bone Marrow Transplant 45(1):159–164. https://doi.org/10.1038/bmt.2009.125

    Article  CAS  PubMed  Google Scholar 

  • Aguilar-Guisado M, Martin-Peña A, Espigado I, Ruiz Perez de Pipaón M, Falantes J, de la Cruz F, Cisneros JM (2012) Universal antifungal therapy is not needed in persistent febrile neutropenia: a tailored diagnostic and therapeutic approach. Haematologica 97(3):464–471. https://doi.org/10.3324/haematol.2011.049999

  • Aguilar-Guisado M, Espigado I, Martin-Peña A, Gudiol C, Royo-Cebrecos C, Falantes J, Vázquez-López L, Montero MI, Rosso-Fernández C, de la Luz MM, Parody R, González-Campos J, Garzón-Lopez S, Calderón-Cabrera C, Barba P, Rodríguez N, Rovira M, Montero-Mateos E, Carratala J, Pérez-Simón JA, Cisneros JM (2017) Optimisation of empiricalantimicrobial therapy in patients with haematological malignancies and febrile neutropenia (how long study): an open-label, randomised, controlled phase 4 trial. Lancet Haematol 4(12):e573–e583. https://doi.org/10.1016/S2352-3026(17)30211-9.

    Google Scholar 

  • Alfandari S, Berthon C, Coiteux V (2014) Antifungal stewardship: implementation in a French teaching hospital. Med Mal Infect 44(4):154–158. https://doi.org/10.1016/j.medmal.2014.01.012

    Article  CAS  PubMed  Google Scholar 

  • Ananda-Rajah MR, Slavin MA, Thursky KT (2012) The case for antifungal stewardship. Curr Opin Infect Dis 25(1):107–115. https://doi.org/10.1097/QCO.0b013e32834e0680

    Article  PubMed  Google Scholar 

  • Ananda-Rajah MR, Martínez D, Slavin MA, Cavedon L, Dooley M, Cheng A, Thursky KA (2014) Facilitating surveillance of pulmonary invasive mold diseases in patients with haematological malignancies by screening computed tomography reports using natural language processing. PLoS One 9(9):e107797. https://doi.org/10.1371/journal.pone.0107797.

  • Ananda-Rajah MR, Bergmeir C, Petitjean F, Slavin MA, Thursky KA, Webb GI (2017) Toward electronic surveillance of invasive Mold diseases in hematology-oncology patients: an expert system combining natural language processing of chest computed tomography reports, microbiology, and antifungal drug data. JCO Clin Cancer Inform 1:1–10. https://doi.org/10.1200/CCI.17.00011.

    Article  PubMed  Google Scholar 

  • Averbuch D, Orasch C, Cordonnier C, Livermore DM, Mikulska M, Viscoli C, Gyssens IC, Kern WV, Klyasova G, Marchetti O, Engelhard D, Akova M, Ecil ajvoEEIEE, Eln (2013) European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European conference on infections in leukemia. Haematologica 98(12):1826–1835. https://doi.org/10.3324/haematol.2013.091025

    Article  PubMed  PubMed Central  Google Scholar 

  • Averbuch D, Tridello G, Hoek J, Mikulska M, Akan H, Yanez San Segundo L, Pabst T, Ozcelik T, Klyasova G, Donnini I, Wu D, Gulbas Z, Zuckerman T, Botelho de Sousa A, Beguin Y, Xhaard A, Bachy E, Ljungman P, de la Cámara R, Rascon J, Ruiz-Camps I, Vitek A, Patriarca F, Cudillo L, Vrhovac R, Shaw PJ, Wolfs T, O'Brien T, Avni B, Silling G, Al Sabty F, Graphakos S, Sankelo M, Sengeloev H, Pillai S, Matthes S, Melanthiou F, Iacobelli S, Styczynski J, Engelhard D, Cesaro S (2017) Antimicrobial resistance in gram-negative rods causing bacteremia in hematopoietic stem cell transplant recipients: intercontinental prospective study of the infectious diseases working Party of the European Bone Marrow Transplantation Group. Clin Infect Dis 65(11):1819–1828. https://doi.org/10.1093/cid/cix646

  • Averbuch D, Tridello G, Hoek J, Mikulska M, Akan H, Yanez San Segundo L, Pabst T, Ozcelik T, Klyasova G, Donnini I, Wu D, Gulbas Z, Zuckerman T, Botelho de Sousa A, Beguin Y, Xhaard A, Bachy E, Ljungman P, de la Cámara R, Rascon J, Ruiz-Camps I, Vitek A, Patriarca F, Cudillo L, Vrhovac R, Shaw PJ, Wolfs T, O’Brien T, Avni B, Silling G, Al Sabty F, Graphakos S, Sankelo M, Sengeloev H, Pillai S, Matthes S, Melanthiou F, Iacobelli S, Styczynski J, Engelhard D, Cesaro S (2017) Antimicrobial resistance in gram-negative rods causing bacteremia in hematopoietic stem cell transplant recipients: intercontinental prospective study of the infectious diseases working Party of the European Bone Marrow Transplantation Group. Clin Infect Dis 65(11):1819–1828.. https://doi.org/10.1080/10428194.2016.1193859

  • Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, Srinivasan A, Dellit TH, Falck-Ytter YT, Fishman NO, Hamilton CW, Jenkins TC, Lipsett PA, Malani PN, May LS, Moran GJ, Neuhauser MM, Newland JG, Ohl CA, Samore MH, Seo SK, Trivedi KK (2016) Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 62(10):e51–e77. https://doi.org/10.1093/cid/ciw118

    Article  PubMed  PubMed Central  Google Scholar 

  • Blumenthal KG, Wickner PG, Hurwitz S, Pricco N, Nee AE, Laskowski K, Shenoy ES, Walensky RP (2017) Tackling inpatient penicillin allergies: assessing tools for antimicrobial stewardship. J Allergy Clin Immunol 140(1):154–161. e156. https://doi.org/10.1016/j.jaci.2017.02.005

    Article  PubMed  PubMed Central  Google Scholar 

  • Bouza E, Guinea J, Pelaez T, Perez-Molina J, Alcala L, Muñoz P (2005) Workload due to Aspergillus fumigatus and significance of the organism in the microbiology laboratory of a general hospital. J Clin Microbiol 43(5):2075–2079. https://doi.org/10.1128/JCM.43.5.2075-2079.2005

  • Bouza E, Muñoz P, Burillo A (2018) Role of the clinical microbiology Laboratory in Antimicrobial Stewardship. Med Clin North Am 102(5):883–898. https://doi.org/10.1016/j.mcna.2018.05.003

  • Bow EJ (2013) There should be no ESKAPE for febrile neutropenic cancer patients: the dearth of effective antibacterial drugs threatens anticancer efficacy. J Antimicrob Chemother 68(3):492–495. https://doi.org/10.1093/jac/dks512

    Article  CAS  PubMed  Google Scholar 

  • Callejas-Díaz A, Gea-Banacloche JC (2014) Clostridium difficile: deleterious impact on hematopoietic stem cell transplantation. Curr Hematol Malig Rep 9(1):85–90. https://doi.org/10.1007/s11899-013-0193-y

  • Caston JJ, Lacort-Peralta I, Martin-Davila P, Loeches B, Tabares S, Temkin L, Torre-Cisneros J, Paño-Pardo JR (2017) Clinical efficacy of ceftazidime/avibactam versus other active agents for the treatment of bacteremia due to carbapenemase-producing Enterobacteriaceae in hematologic patients. Int J Infect Dis 59:118–123. https://doi.org/10.1016/j.ijid.2017.03.021

  • Cattaneo C, Di Blasi R, Skert C, Candoni A, Martino B, Di Renzo N, Delia M, Ballanti S, Marchesi F, Mancini V, Orciuolo E, Cesaro S, Prezioso L, Fanci R, Nadali G, Chierichini A, Facchini L, Picardi M, Malagola M, Orlando V, Trecarichi EM, Tumbarello M, Aversa F, Rossi G, Pagano L, Group S (2018) Bloodstream infections in haematological cancer patients colonized by multidrug-resistant bacteria. Ann Hematol. https://doi.org/10.1007/s00277-018-3341-6

  • Cornely OA, Koehler P, Arenz D, CM S (2018) EQUAL Aspergillosis score 2018: an ECMM score derived from current guidelines to measure QUALity of the clinical management of invasive pulmonary aspergillosis. Mycoses 61(11):833–836. https://doi.org/10.1111/myc.12820

    Article  PubMed  Google Scholar 

  • Cuervo G, García-Vidal C, Puig-Asensio M, Merino P, Vena A, Martin-Peña A, Montejo JM, Ruiz A, Lázaro-Perona F, Fortún J, Fernández-Ruiz M, Suárez AI, Castro C, Cardozo C,Gudiol C, Aguado JM, Paño JR, Pemán J, Salavert M, Garnacho-Montero J, Cisneros JM, Soriano A, Muñoz P, Almirante B, Carratalá J, Reipi tG, the Spanish C-BG (2018) Usefulness of guideline recommendations for prognosis in patients with candidemia. Med Mycol. https://doi.org/10.1093/mmy/myy118

  • des Champs-Bro B, Leroy-Cotteau A, Mazingue F, Pasquier F, Francois N, Corm S, Lemaitre L, Poulain D, Yakoub-Agha I, Alfandari S, Sendid B (2011) Invasive fungal infections: epidemiology and analysis of antifungal prescriptions in onco-haematology. J Clin Pharm Ther 36(2):152–160. https://doi.org/10.1111/j.1365-2710.2010.01166.x

    Article  CAS  PubMed  Google Scholar 

  • Duarte RF, Sánchez-Ortega I, Cuesta I, Arnan M, Patino B, Fernández de Sevilla A, Gudiol C, Ayats J, Cuenca-Estrella M (2014) Serum galactomannan-based early detection of invasive aspergillosis in hematology patients receiving effective antimold prophylaxis. Clin Infect Dis 59(12):1696–1702. https://doi.org/10.1093/cid/ciu673

  • Duarte RF, Sánchez-Ortega I, Arnan M, Patino B, Ayats J, Sureda A, Cuenca-Estrella M (2017) Serum galactomannan surveillance may be safely withdrawn from antifungal management of hematology patients on effective antimold prophylaxis: a pilot single-center study. Bone Marrow Transplant 52(2):326–329. https://doi.org/10.1038/bmt.2016.279

  • Dyar OJ, Huttner B, Schouten J, Pulcini C, Esgap (2017) What is antimicrobial stewardship? Clin Microbiol Infect 23(11):793–798. https://doi.org/10.1016/j.cmi.2017.08.026

  • Escribano P, Peláez T, Muñoz P, Bouza E, Guinea J (2013) Is azole resistance in Aspergillus fumigatus a problem in Spain? Antimicrob Agents Chemother 57(6):2815–2820. https://doi.org/10.1128/AAC.02487-12

  • Escribano P, Marcos-Zambrano LJ, Peláez T, Muñoz P, Padilla B, Bouza E, Guinea J (2015) Sputum and bronchial secretion samples are equally useful as Broncho alveolar lavage samples for the diagnosis of invasive pulmonary aspergillosis in selected patients. Med Mycol 53(3):235–240. https://doi.org/10.1093/mmy/myu090

  • Fernández-Cruz A, Alba N, Semiglia-Chong MA, Padilla B, Rodríguez-Macías G, Kwon M, Cercenado E, Chamorro-de-Vega E, Machado M, Pérez-Lago L, de Viedma DG, Díez Martín JL, Muñoz P (2018) Real-life experience with ceftolozane/tazobactam in patients with hematologic malignancy and Pseudomonas aeruginosa infection: a case-control study. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.02340-18

  • Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR, Infectious Diseases Society of A (2011) Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 52(4):427–431. https://doi.org/10.1093/cid/ciq147

    Article  PubMed  Google Scholar 

  • Girmenia C, Rossolini GM, Piciocchi A, Bertaina A, Pisapia G, Pastore D, Sica S, Severino A, Cudillo L, Ciceri F, Scime R, Lombardini L, Viscoli C, Rambaldi A, Gruppo Italiano Trapianto Midollo O, Gruppo Italiano Trapianto Midollo Osseo G (2015) Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy. Bone Marrow Transplant 50(2):282–288. https://doi.org/10.1038/bmt.2014.231

    Article  CAS  PubMed  Google Scholar 

  • Gudiol C, Tubau F, Calatayud L, García-Vidal C, Cisnal M, Sanchez-Ortega I, Duarte R, Calvo M, Carratalá J (2011) Bacteraemia due to multidrug-resistant gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes. J Antimicrob Chemother 66(3):657–663. https://doi.org/10.1093/jac/dkq494

  • Gustinetti G, Raiola AM, Varaldo R, Galaverna F, Gualandi F, Del Bono V, Bacigalupo A, Angelucci E, Viscoli C, Mikulska M (2018) De-escalation and discontinuation of empirical antibiotic treatment in a cohort of allogeneic hematopoietic stem cell transplantation recipients during the pre-engraftment period. Biol Blood Marrow Transplant 24(8):1721–1726. https://doi.org/10.1016/j.bbmt.2018.03.018

    Article  PubMed  Google Scholar 

  • Gyssens IC, Kern WV, Livermore DM, Ecil ajvoEEI, ESCMID Eo (2013) The role of antibiotic stewardship in limiting antibacterial resistance among hematology patients. Haematologica 98(12):1821–1825. https://doi.org/10.3324/haematol.2013.091769

    Article  PubMed  PubMed Central  Google Scholar 

  • Hamilton KW, Gerber JS, Moehring R, Anderson DJ, Calderwood MS, Han JH, Mehta JM, Pollack LA, Zaoutis T, Srinivasan A, Camins BC, Schwartz DN, Lautenbach E, Centers for Disease C, Prevention Epicenters P (2015) Point-of-prescription interventions to improve antimicrobial stewardship. Clin Infect Dis 60(8):1252–1258. https://doi.org/10.1093/cid/civ018

    Article  PubMed  PubMed Central  Google Scholar 

  • Hennig S, Staatz CE, Natanek D, Bialkowski S, Consuelo Llanos Paez C, Lawson R, Clark J (2018) Antimicrobial stewardship in paediatric oncology: impact on optimising gentamicin use in febrile neutropenia. Pediatr Blood Cancer 65(2). https://doi.org/10.1002/pbc.26810

  • Katsios CM, Burry L, Nelson S, Jivraj T, Lapinsky SE, Wax RS, Christian M, Mehta S, Bell CM, Morris AM (2012) An antimicrobial stewardship program improves antimicrobial treatment by culture site and the quality of antimicrobial prescribing in critically ill patients. Crit Care 16(6):R216. https://doi.org/10.1186/cc11854

    Article  PubMed  PubMed Central  Google Scholar 

  • Lachenmayr SJ, Berking S, Horns H, Strobeck D, Oysterman H, Berger K (2018) Antifungal treatment in haematological and oncological patients: need for quality assessment in routine care. Mycoses 61(7):464–471. https://doi.org/10.1111/myc.12768

    Article  PubMed  Google Scholar 

  • Le Clech L, Talarmin JP, Couturier MA, Ianotto JC, Nicol C, Le Calloch R, Dos Santos S, Hutin P, Tande D, Cogulet V, Berthou C, Guillerm G (2018) Early discontinuation of empirical antibacterial therapy in febrile neutropenia: the ANTIBIOSTOP study. Infect Dis (Lond):1–11. https://doi.org/10.1080/23744235.2018.1438649

  • López-Medrano F, Aguado JM (2015) Invasive fungal disease: an entity with enough complexity to justify the existence of specialists in its management. Enferm Infecc Microbiol Clin 33(4):219–220. https://doi.org/10.1016/j.eimc.2015.01.001

  • López-Medrano F, Moreno-Ramos F, de Cueto M, Mora-Rillo M, Salavert M (2013a) How to assist clinicians in improving antimicrobial prescribing: tools and interventions provided by stewardship programs. Enferm Infecc Microbiol Clin 31(Suppl 4):38–44. https://doi.org/10.1016/S0213-005X(13)70131-9

  • López-Medrano F, Juan RS, Lizasoain M, Catalan M, Ferrari JM, Chaves F, Lumbreras C, Montejo JC, de Tejada AH, Aguado JM (2013b) A non-compulsory stewardship programme for the management of antifungals in a university-affiliated hospital. Clin Microbiol Infect 19(1):56–61. https://doi.org/10.1111/j.1469-0691.2012.03891.x

  • Madran B, Keske S, Tokca G, Donmez E, Ferhanoglu B, Cetiner M, Mandel NM, Ergonul O (2017) Implementation of an antimicrobial stewardship program for patients with febrile neutropenia. Am J Infect Control. https://doi.org/10.1016/j.ajic.2017.09.030

  • Mani S, Rybicki L, Jagadeesh D, Mossad SB (2016) Risk factors for recurrent Clostridium difficile infection in allogeneic hematopoietic cell transplant recipients. Bone Marrow Transplant 51(5):713–717. https://doi.org/10.1038/bmt.2015.311

    Article  CAS  PubMed  Google Scholar 

  • Martin-Peña A, Gil-Navarro MV, Aguilar-Guisado M, Espigado I, de Pipaón MR, Falantes J, Pachón J, Cisneros JM (2013) Cost-effectiveness analysis comparing two approaches for empirical antifungal therapy in hematological patients with persistent febrile neutropenia. Antimicrob Agents Chemother 57(10):4664–4672. https://doi.org/10.1128/AAC.00723-13

  • Martín-Rabadan P, Gijón P, Alonso Fernásndez R, Ballesteros M, Anguita J, Bouza E (2012) False-positive Aspergillus antigenemia due to blood product conditioning fluids. Clin Infect Dis 55(4):e22–e27. https://doi.org/10.1093/cid/cis493

  • la Martire G, Robin C, Oubaya N, Lepeule R, Beckerich F, Leclerc M, Barhoumi W, Toma A, Pautas C, Maury S, Akrout W, Cordonnier-Jourdin C, Fihman V, Venditti M, Cordonnier C (2018) De-escalation and discontinuation strategies in high-risk neutropenic patients: an interrupted time series analyses of antimicrobial consumption and impact on outcome. Eur J Clin Microbiol Infect Dis 37(10):1931–1940. https://doi.org/10.1007/s10096-018-3328-1

    Article  CAS  PubMed  Google Scholar 

  • McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, Loo V, Shaklee Sammons J, Sandora TJ, Wilcox MH (2018) Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 66(7):987–994. https://doi.org/10.1093/cid/ciy149

    Article  CAS  PubMed  Google Scholar 

  • Mellinghoff SC, Hartmann P, Cornely FB, Knauth L, Kohler F, Kohler P, Krause C, Kronenberg C, Kranz SL, Menon V, Muller H, Naendrup JH, Putzfeld S, Ronge A, Rutz J, Seidel D, Wisplinghoff H, Cornely OA (2018a) Analyzing candidemia guideline adherence identifies opportunities for antifungal stewardship. Eur J Clin Microbiol Infect Dis 37(8):1563–1571. https://doi.org/10.1007/s10096-018-3285-8

    Article  CAS  PubMed  Google Scholar 

  • Mellinghoff SC, Hoenigl M, Koehler P, Kumar A, Lagrou K, Lass-Florl C, Meis JF, Menon V, Rautemaa-Richardson R, Cornely OA (2018b) EQUAL Candida score: an ECMM score derived from current guidelines to measure QUAlity of clinical Candidaemia management. Mycoses 61(5):326–330. https://doi.org/10.1111/myc.12746

    Article  PubMed  Google Scholar 

  • Mensa J, Barberán J, Soriano A, Llinares P, Marco F, Cantón R, Bou G, González Del Castillo J, Maseda E, Azanza JR, Pasquau J, García-Vidal C, Reguera JM, Sousa D, Gomez J, Montejo M, Borges M, Torres A, Álvarez-Lerma F, Salavert M, Zaragoza R, Oliver A (2018) Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: guidelines by the Spanish Society of Chemotherapy. Rev Esp Quimioter 31(1):78–100

    Google Scholar 

  • Messacar K, Parker SK, Todd JK, Dominguez SR (2017) Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship. J Clin Microbiol 55(3):715–723. https://doi.org/10.1128/JCM.02264-16

    Article  PubMed  PubMed Central  Google Scholar 

  • Mikulska M, Averbuch D, Tissot F, Cordonnier C, Akova M, Calandra T, Ceppi M, Bruzzi P, Viscoli C, European Conference on Infections in L (2018) Fluoroquinolone prophylaxis in haematological cancer patients with neutropenia: ECIL critical appraisal of previous guidelines. J Infect 76(1):20–37. https://doi.org/10.1016/j.jinf.2017.10.009

    Article  PubMed  Google Scholar 

  • Miller RA (2018) A case for antifungal stewardship. Curr Fungal Infect Rep 12(33). https://doi.org/10.1007/s12281-018-0307-z

  • Molina J, Penalva G, Gil-Navarro MV, Praena J, Lepe JA, Pérez-Moreno MA, Ferrándiz C, Aldabo T, Aguilar M, Olbrich P, Jimenez-Mejias ME, Gascon ML, Amaya-Villar R, Neth O, Rodríguez-Hernandez MJ, Gutierrez-Pizarraya A, Garnacho-Montero J, Montero C, Cano J, Palomino J, Valencia R, Álvarez R, Cordero E, Herrero M, Cisneros JM, team P (2017) Long-term impact of an educational antimicrobial stewardship program on hospital-acquired Candidemia and multidrug-resistant bloodstream infections: a quasi-experimental study of interrupted time-series analysis. Clin Infect Dis 65(12):1992–1999. https://doi.org/10.1093/cid/cix692

  • Mondain V, Lieutier F, Hasseine L, Gari-Toussaint M, Poiree M, Lions C, Pulcini C (2013) A 6-year antifungal stewardship programme in a teaching hospital. Infection 41(3):621–628. https://doi.org/10.1007/s15010-013-0431-1

    Article  CAS  PubMed  Google Scholar 

  • Morley GL, Wacogne ID (2017) UK recommendations for combating antimicrobial resistance: a review of 'antimicrobial stewardship: systems and processes for effective antimicrobial medicine use' (NICE guideline NG15, 2015) and related guidance. Arch Dis Child Educ Pract Ed. https://doi.org/10.1136/archdischild-2016-311557

  • Muñoz P, Rojas L, Cervera C, Garrido G, Fariñas MC, Valerio M, Giannella M, Bouza E, Group CS (2012) Poor compliance with antifungal drug use guidelines by transplant physicians: a framework for educational guidelines and an international consensus on patient safety. Clin Transpl 26(1):87–96. https://doi.org/10.1111/j.1399-0012.2011.01405.x

  • Orasch C, Averbuch D, Mikulska M, Cordonnier C, Livermore DM, Gyssens IC, Klyasova G, Engelhard D, Kern W, Viscoli C, Akova M, Marchetti O, th European Conference on Infections in L, joint venture of Infectious Diseases Working Party of the European Group for B, Marrow T, Infectious Diseases Group of the European Organization for R, Treatment of C, International Immunocompromised Host S, European Leukemia N, European Study Group on Infections in Immunocompromised Hosts of the European Society for Clinical M, Infectious D (2015) Discontinuation of empirical antibiotic therapy in neutropenic leukaemia patients with fever of unknown origin is ethical. Clin Microbiol Infect 21(3):e25–e27. https://doi.org/10.1016/j.cmi.2014.10.014

    Article  CAS  PubMed  Google Scholar 

  • Paño-Pardo JR, Campos J, Natera Kindelan C, Ramos A (2013) Initiatives and resources to promote antimicrobial stewardship. Enferm Infecc Microbiol Clin 31(Suppl 4):51–55. https://doi.org/10.1016/S0213-005X(13)70133-2

  • Patel R, Fang FC (2018) Diagnostic stewardship: opportunity for a laboratory-infectious diseases partnership. Clin Infect Dis 67(5):799–801. https://doi.org/10.1093/cid/ciy077

    Article  PubMed  PubMed Central  Google Scholar 

  • Pulcini C, Binda F, Lamkang AS, Trett A, Charani E, Goff DA, Harbarth S, Hinrichsen SL, Levy-Hara G, Mendelson M, Nathwani D, Gunturu R, Singh S, Srinivasan A, Thamlikitkul V, Thursky K, Vlieghe E, Wertheim H, Zeng M, Gandra S, Laxminarayan R (2018) Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach. Clin Microbiol Infect. https://doi.org/10.1016/j.cmi.2018.03.033

  • Pulcini C, Binda F, Lamkang AS, Trett A, Charani E, Goff DA, Harbarth S, Hinrichsen SL, Levy-Hara G, Mendelson M, Nathwani D, Gunturu R, Singh S, Srinivasan A, Thamlikitkul V, Thursky K, Vlieghe E, Wertheim H, Zeng M, Gandra S, Laxminarayan R (2019) Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach. Clin Microbiol Infect 25(1):20–25. https://doi.org/10.1016/j.cmi.2018.03.033

    Article  CAS  PubMed  Google Scholar 

  • Ramos A, Pérez-Velilla C, Asensio A, Ruiz-Antorán B, Folguera C, Cantero M, Orden B, Muñez E (2015) Antifungal stewardship in a tertiary hospital. Rev Iberoam Micol 32(4):209–213. https://doi.org/10.1016/j.riam.2014.11.006

  • Ramsey A, Staicu ML (2018) Use of a penicillin allergy screening algorithm and penicillin skin testing for transitioning hospitalized patients to first-line antibiotic therapy. J Allergy Clin Immunol Pract 6(4):1349–1355. https://doi.org/10.1016/j.jaip.2017.11.012

    Article  PubMed  Google Scholar 

  • Rautemaa-Richardson R, Rautemaa V, Al-Wathiqi F, Moore CB, Craig L, Felton TW, Muldoon EG (2018) Impact of a diagnostics-driven antifungal stewardship programme in a UK tertiary referral teaching hospital. J Antimicrob Chemother 73(12):3488–3495. https://doi.org/10.1093/jac/dky360

    Article  CAS  PubMed  Google Scholar 

  • Robilotti E, Holubar M, Seo SK, Deresinski S (2017) Feasibility and applicability of antimicrobial stewardship in immunocompromised patients. Curr Opin Infect Dis 30(4):346–353. https://doi.org/10.1097/QCO.0000000000000380

    Article  PubMed  Google Scholar 

  • Rodríguez-Baño J, Paño-Pardo JR, Álvarez-Rocha L, Asensio A, Calbo E, Cercenado E, Cisneros JM, Cobo J, Delgado O, Garnacho-Montero J, Grau S, Horcajada JP, Hornero A, Murillas-Angoiti J, Oliver A, Padilla B, Pasquau J, Pujol M, Ruiz-Garbajosa P, San Juan R, Sierra R, Grupo de Estudio de la Infeccion Hospitalaria-Sociedad Espanola de Enfermedades Infecciosas y Microbiologia C, Sociedad Espanola de Farmacia H, Sociedad Espanola de Medicina Preventiva SPeH (2012) Programs for optimizing the use of antibiotics (PROA) in Spanish hospitals: GEIH-SEIMC, SEFH and SEMPSPH consensus document. Enferm Infecc Microbiol Clin 22(1):e21–22 e23. https://doi.org/10.1016/j.eimc.2011.09.018

  • Rosa RG, Goldani LZ, dos Santos RP (2014) Association between adherence to an antimicrobial stewardship program and mortality among hospitalised cancer patients with febrile neutropaenia: a prospective cohort study. BMC Infect Dis 14:286. https://doi.org/10.1186/1471-2334-14-286

    Article  PubMed  PubMed Central  Google Scholar 

  • Ruiz-Ramos J, Frasquet J, Poveda-Andres JL, Roma E, Salavert-Lleti M, Castellanos A, Ramírez P (2017) Impact of an antimicrobial stewardship program on critical haematological patients. Farm Hosp 41(4):479–487. https://doi.org/10.7399/fh.2017.41.4.10709

  • Santolaya ME, Álvarez AM, Acuna M, Avilés CL, Salgado C, Tordecilla J, Varas M, Venegas M, Villarroel M, Zubieta M, Toso A, Bataszew A, Farfán MJ, de la Maza V, Vergara A, Valenzuela R, Torres JP (2017) Efficacy and safety of withholding antimicrobial treatment in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial. Clin Microbiol Infect 23(3):173–178. https://doi.org/10.1016/j.cmi.2016.11.001

  • Shlaes DM, Gerding DN, John JF Jr, Craig WA, Bornstein DL, Duncan RA, Eckman MR, Farrer WE, Greene WH, Lorian V, Levy S, McGowan JE Jr, Paul SM, Ruskin J, Tenover FC, Watanakunakorn C (1997) Society for Healthcare Epidemiology of America and Infectious Diseases Society of America joint committee on the Prevention of antimicrobial resistance: guidelines for the prevention of antimicrobial resistance in hospitals. Clin Infect Dis 25(3):584–599

    Article  CAS  Google Scholar 

  • Snyder M, Pasikhova Y, Baluch A (2017) Early antimicrobial De-escalation and stewardship in adult hematopoietic stem cell transplantation recipients: retrospective review. Open forum. Infect Dis 4(4):ofx226. https://doi.org/10.1093/ofid/ofx226

    Article  Google Scholar 

  • So M, Mamdani MM, Morris AM, Lau TTY, Broady R, Deotare U, Grant J, Kim D, Schimmer AD, Schuh AC, Shajari S, Steinberg M, Bell CM, Husain S (2018) Effect of an antimicrobial stewardship programme on antimicrobial utilisation and costs in patients with leukaemia: a retrospective controlled study. Clin Microbiol Infect 24(8):882–888. https://doi.org/10.1016/j.cmi.2017.11.009

    Article  CAS  PubMed  Google Scholar 

  • Spec A, Mejia-Chew C, Powderly WG, Cornely OA (2018) EQUAL Cryptococcus score 2018: a European Confederation of Medical Mycology Score Derived from Current Guidelines to measure QUALity of clinical Cryptococcosis management. Open forum infect dis 5 (11):ofy299. https://doi.org/10.1093/ofid/ofy299

  • Stanzani M, Vianelli N, Cavo M, Maritati A, Morotti M, Lewis RE (2017) Retrospective cohort analysis of liposomal amphotericin B nephrotoxicity in patients with hematological malignancies. Antimicrob Agents Chemother 61(9). https://doi.org/10.1128/AAC.02651-16

  • Theuretzbacher U (2012) Pharmacokinetic and pharmacodynamic issues for antimicrobial therapy in patients with cancer. Clin Infect Dis 54(12):1785–1792. https://doi.org/10.1093/cid/cis210

    Article  CAS  PubMed  Google Scholar 

  • Timbrook TT, Hurst JM, Bosso JA (2016) Impact of an antimicrobial stewardship program on antimicrobial utilization, bacterial susceptibilities, and financial expenditures at an Academic Medical Center. Hosp Pharm 51(9):703–711. https://doi.org/10.1310/hpj5109-703

    Article  PubMed  PubMed Central  Google Scholar 

  • Trubiano JA, Thursky KA, Stewardson AJ, Urbancic K, Worth LJ, Jackson C, Stevenson W, Sutherland M, Slavin MA, Grayson ML, Phillips EJ (2017) Impact of an integrated antibiotic allergy testing program on antimicrobial stewardship: a multicenter evaluation. Clin Infect Dis 65(1):166–174. https://doi.org/10.1093/cid/cix244

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Valerio M, Rodríguez-González CG, Munoz P, Cáliz B, Sanjurjo M, Bouza E, Group CS (2014) Evaluation of antifungal use in a tertiary care institution: antifungal stewardship urgently needed. J Antimicrob Chemother 69(7):1993–1999. https://doi.org/10.1093/jac/dku053

  • Valerio M, Muñoz P, Rodríguez CG, Caliz B, Padilla B, Fernández-Cruz A, Sánchez-Somolinos M, Gijón P, Peral J, Gayoso J, Frías I, Salcedo M, Sanjurjo M, Bouza E, Mycosis CSGCGo (2015a) Antifungal stewardship in a tertiary-care institution: a bedside intervention. Clin Microbiol Infect 21(5):492 e491–492 e499. https://doi.org/10.1016/j.cmi.2015.01.013

  • Valerio M, Vena A, Bouza E, Reiter N, Viale P, Hochreiter M, Giannella M, Munoz P, group Cs (2015b) How much European prescribing physicians know about invasive fungal infections management? BMC Infect Dis 15:80. https://doi.org/10.1186/s12879-015-0809-z

  • Valerio M, Muñoz P, Rodríguez-González C, Sanjurjo M, Guinea J, Bouza E, group Cs (2015c) Training should be the first step toward an antifungal stewardship program. Enferm Infecc Microbiol Clin 33(4):221–227. https://doi.org/10.1016/j.eimc.2014.04.016

  • Valerio M, Vena A, Rodríguez-González CG, de Vega EC, Mateos M, Sanjurjo M, Bouza E, Muñoz P, Group CS (2018) Repeated antifungal use audits are essential for selecting the targets for intervention in antifungal stewardship. Eur J Clin Microbiol Infect Dis 37(10):1993–2000. https://doi.org/10.1007/s10096-018-3335-2

  • Vazquez J, Reboli AC, Pappas PG, Patterson TF, Reinhardt J, Chin-Hong P, Tobin E, Kett DH, Biswas P, Swanson R (2014) Evaluation of an early step-down strategy from intravenous anidulafungin to oral azole therapy for the treatment of candidemia and other forms of invasive candidiasis: results from an open-label trial. BMC Infect Dis 14:97. https://doi.org/10.1186/1471-2334-14-97

  • Vena A, Bouza E, Álvarez-Uría A, Gayoso J, Martín-Rabadán P, Cajuste F, Guinea J, Gomez Castellá J, Alonso R, Muñoz P (2017) The misleading effect of serum galactomannan testing in high-risk haematology patients receiving prophylaxis with micafungin. Clin Microbiol Infect 23(12):1000 e1001–1000 e1004. https://doi.org/10.1016/j.cmi.2017.05.006

  • Viale P, Giannella M, Bartoletti M, Tedeschi S, Lewis R (2015) Considerations about antimicrobial stewardship in settings with epidemic extended-Spectrum beta-lactamase-producing or Carbapenem-resistant Enterobacteriaceae. Infect Dis Ther 4(Suppl 1):65–83. https://doi.org/10.1007/s40121-015-0081-y

    Article  PubMed  PubMed Central  Google Scholar 

  • Whitney L, Al-Ghusein H, Glass S, Koh M, Klammer M, Ball J, Youngs J, Wake R, Houston A, Bicanic T (2019) Effectiveness of an antifungal stewardship programme at a London teaching hospital 2010-16. J Antimicrob Chemother 74(1):234–241. https://doi.org/10.1093/jac/dky389

    Article  CAS  PubMed  Google Scholar 

  • de With K, Allerberger F, Amann S, Apfalter P, Brodt HR, Eckmanns T, Fellhauer M, Geiss HK, Janata O, Krause R, Lemmen S, Meyer E, Mittermayer H, Porsche U, Presterl E, Reuter S, Sinha B, Strauss R, Wechsler-Fordos A, Wenisch C, Kern WV (2016) Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases. Infection 44(3):395–439. https://doi.org/10.1007/s15010-016-0885-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yeo CL, Chan DS, Earnest A, Wu TS, Yeoh SF, Lim R, Jureen R, Fisher D, Hsu LY (2012) Prospective audit and feedback on antibiotic prescription in an adult hematology-oncology unit in Singapore. Eur J Clin Microbiol Infect Dis 31(4):583–590. https://doi.org/10.1007/s10096-011-1351-6

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain

    Patricia Muñoz

  2. Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Madrid, Spain

    Patricia Muñoz

  3. Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain

    Patricia Muñoz

  4. CIBER de Enfermedades Respiratorias (CIBERES CB06/06/0058), Madrid, Spain

    Patricia Muñoz

  5. Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain

    Ana Fernández-Cruz

  6. Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana, Madrid, Spain

    Ana Fernández-Cruz

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  1. Patricia Muñoz
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Correspondence to Patricia Muñoz .

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  1. Department I for Internal Medicine, CECAD Translational Research Institute, University Hospital of Cologne, Cologne, Germany

    Oliver A. Cornely

  2. Department of Internal Medicine, Medical University of Graz, Graz, Steiermark, Austria

    Martin Hoenigl

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Muñoz, P., Fernández-Cruz, A. (2021). Antimicrobial Stewardship. In: Cornely, O.A., Hoenigl, M. (eds) Infection Management in Hematology. Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-030-57317-1_9

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