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Bone Marrow-Derived Cells: From the Laboratory to the Clinic

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Stem Cell Therapy for Vascular Diseases

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Abstract

Bone marrow mononuclear cells (BMMNC) are enriched with a variety of angiogenic stem and progenitor cells, as well as mature hematopoietic cells that function synergistically to promote neovascularization. Delivery of BMMNC or its subpopulations have demonstrated marked effects on revascularization of ischemic tissue in preclinical models. Extensive phase I and II clinical trials in critical limb ischemia (CLI) patients have established the safety of BMMNC and showed promising effects of the cells to improve ischemic rest pain and promote ulcer healing, pain-free walking distance, ABI, and TcPO2. This book chapter introduces the concept of BMMNC and its subpopulations in the context of peripheral arterial disease. It also discusses the animal models of CLI in which mechanisms of bone marrow-derived cells were investigated. Finally, the progress in the clinical trials using BMMNC to treat CLI patients were summarized, and the challenges were discussed.

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Authors and Affiliations

  1. Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Justin R. King, Jie Xie & Michael P. Murphy

  2. Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

    Justin R. King, Jie Xie & Michael P. Murphy

  3. Center for Regenerative Medicine, Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA

    Justin R. King & Michael P. Murphy

Authors
  1. Justin R. King
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  2. Jie Xie
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  3. Michael P. Murphy
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Correspondence to Michael P. Murphy .

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Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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King, J.R., Xie, J., Murphy, M.P. (2021). Bone Marrow-Derived Cells: From the Laboratory to the Clinic. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_5

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  • DOI: https://doi.org/10.1007/978-3-030-56954-9_5

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