Skip to main content

Blood Pressure and Hypertension Management

  • Chapter
  • First Online:
ASPC Manual of Preventive Cardiology

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

The prevention and management of hypertension remains a significant public health problem. The recent recommendations for the management of high blood pressure by the American College of Cardiology/American Heart Association (ACC/AHA) have redefined hypertension at a blood pressure of 130/80 mmHg or greater. Blood pressure management requires an understanding of both non-pharmacologic and pharmacologic interventions, as well as the major cardiovascular disease (CVD) risk factors. The recommended approach to treating blood pressure in patients with hypertension starts with the appropriate measurement of blood pressure, with an increased emphasis on home and ambulatory monitoring. This is followed by blood pressure staging and if Stage 1 (130–139/80–89 mmHg) or Stage 2 (≥140/90 mmHg), and then the initiation of nonpharmacologic interventions such as smoking cessation in tobacco users, a vegetable-rich diet, daily walking and/or exercise three times a week, and other healthy lifestyle strategies. For those with a blood pressure of ≥130/80 mmHg who have a 10-year atherosclerotic CV disease (ASCVD) risk of ≥10%, the initiation of pharmacologic therapy is recommended with a target blood pressure of <130/80 mmHg for most adults. This risk level captures the majority of people with hypertension who could benefit from pharmacologic therapy. Optimal blood pressure control necessitates an appropriate sensitivity to and an understanding of demographic, socio-cultural, and other factors that may act as barriers to a recommended care plan and promotion of adherence to not only improve blood pressure control but to address cardiovascular risk factors to reduce premature morbidity and mortality.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139–596.

    Article  PubMed  Google Scholar 

  2. Rui P, Okeyode T. National ambulatory medical care survey: 2016 national summary tables. Available at: https://www.cdc.gov/nchs/data/ahcd/namcs_summary/2016_namcs_web_tables.pdf. Accessed 12 June 2020.

  3. Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Circulation. 2018;138(17):e484–594.

    PubMed  Google Scholar 

  4. Martins D, Norris K. Diagnosis and treatment of secondary hypertension. International textbook of cardiology. London UK: Mosby International Limited; 2003, p. 553–62.

    Google Scholar 

  5. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42(6):1206–52.

    Article  CAS  PubMed  Google Scholar 

  6. Chobanian AV. Guidelines for the management of hypertension. Med Clin North Am. 2017;101(1):219–27.

    Article  PubMed  Google Scholar 

  7. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APHA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines. Hypertension. 2018;71(6):1269–324.

    Article  CAS  PubMed  Google Scholar 

  8. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507–20.

    Article  CAS  PubMed  Google Scholar 

  9. Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103–16.

    Article  CAS  PubMed  Google Scholar 

  10. Kjeldsen SE, Lund-Johansen P, Nilsson PM, Mancia G. Unattended blood pressure measurements in the systolic blood pressure intervention trial: implications for entry and achieved blood pressure values compared with other trials. Hypertension. 2016;67(5):808–12.

    Article  CAS  PubMed  Google Scholar 

  11. Chrysant SG, Chrysant GS. Effectiveness of lowering blood pressure to prevent stroke versus to prevent coronary events. Am J Cardiol. 2010;106(6):825–9.

    Article  PubMed  Google Scholar 

  12. Brunstrom M, Carlberg B. Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses. BMJ. 2016;352:i717.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Reboussin DM, Carey RM, Whelton PK. Evidence supporting the blood pressure treatment goal of less than 130/80 mm Hg. Hypertension. 2019;73(5):972–4.

    Article  CAS  PubMed  Google Scholar 

  14. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36(10):1953–2041.

    Article  CAS  PubMed  Google Scholar 

  15. American Diabetes Association. (8) Cardiovascular disease and risk management. Diabetes Care. 2015;38(Supplement 1):S49.

    Article  Google Scholar 

  16. National Guideline C. National Institute for Health and Care Excellence: clinical guidelines. Hypertension in adults: diagnosis and management. London: National Institute for Health and Care Excellence (UK) Copyright (c) NICE 2019; 2019.

    Google Scholar 

  17. American Academy of Family Physicians clinical practice guideline for the management of high blood pressure in adults. Accessed 7 Feb 2019 at https://www.aafp.org/patient-care/clinical-recommendations/all/highbloodpressure.html

  18. American Diabetes Association. 10. Cardiovascular disease and risk management: standards of medical care in diabetes-2019. Diabetes care. 2019;42(Suppl 1):S103–23.

    Google Scholar 

  19. Harrap Stephen B, Lung T, Chalmers J. New blood pressure guidelines pose difficult choices for Australian physicians. Circ Res. 2019;124(7):975–7.

    Article  CAS  PubMed  Google Scholar 

  20. Nerenberg KA, Zarnke KB, Leung AA, Dasgupta K, Butalia S, McBrien K, et al. Hypertension Canada’s 2018 guidelines for diagnosis, risk assessment, prevention, and treatment of hypertension in adults and children. Can J Cardiol. 2018;34(5):506–25.

    Article  PubMed  Google Scholar 

  21. Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, et al. Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged >/=75 years: a randomized clinical trial. JAMA. 2016;315(24):2673–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Economic costs of diabetes in the U.S. in 2017. Diabetes care. 2018;41(5):917–28.

    Google Scholar 

  23. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Lancet Diabetes Endocrinol. 2014;2(8):634–47.

    Google Scholar 

  24. Cushman WC, Evans GW, Byington RP, Goff DC Jr, Grimm RH Jr, Cutler JA, et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1575–85.

    Article  PubMed  CAS  Google Scholar 

  25. Mayor S. Intensive glucose lowering arm of diabetes trial is stopped after excess deaths. Br Med J (Clin Res ed). 2008;336(7641):407.

    Google Scholar 

  26. Beddhu S, Chertow GM, Greene T, Whelton PK, Ambrosius WT, Cheung AK, et al. Effects of intensive systolic blood pressure lowering on cardiovascular events and mortality in patients with type 2 diabetes mellitus on standard glycemic control and in those without diabetes mellitus: reconciling results from ACCORD BP and SPRINT. J Am Heart Assoc. 2018;7(18):e009326.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Buckley LF, Dixon DL, Wohlford GF, Wijesinghe DS, Baker WL, Van Tassell BW. Intensive versus standard blood pressure control in SPRINT-eligible participants of ACCORD-BP. Diabetes Care. 2017;40(12):1733–8.

    Article  CAS  PubMed  Google Scholar 

  28. Liu HH, Cao YX, Li S, Guo YL, Zhu CG, Wu NQ, et al. Impacts of prediabetes mellitus alone or plus hypertension on the coronary severity and cardiovascular outcomes. Hypertension. 2018;71(6):1039–46.

    Article  CAS  PubMed  Google Scholar 

  29. Shen JI, Nicholas SB, Williams S, Norris KC. Evidence for and against ACC/AHA 2017 guideline for target systolic blood pressure of < 130 mmHg in persons with type 2 diabetes. Curr Cardiol Rep. 2019;21(11):149.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Norris KC, Brown AF. The highs and lows of blood pressure targets in elderly adults and other high-risk populations. J Am Geriatr Soc. 2015;63(10):2139–41.

    Article  PubMed  Google Scholar 

  31. Anderson TS, Odden M, Penko J, Kazi DS, Bellows BK, Bibbins-Domingo K. Generalizability of clinical trials supporting the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline. JAMA Intern Med. 2020;180(5):795–7.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Kalra S, Kishor K, Gupta Y. Patient-centered blood pressure: thresholds, targets, and tools in diabetes. Indian J Endocrinol Metab. 2017;21(2):261–4.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Nicholas SB, Vaziri ND, Norris KC. What should be the blood pressure target for patients with chronic kidney disease? Curr Opin Cardiol. 2013;28(4):439–45.

    PubMed  Google Scholar 

  34. Muntner P, Shimbo D, Carey RM, Charleston JB, Gaillard T, Misra S, et al. Measurement of blood pressure in humans: a scientific statement from the American Heart Association. Hypertension. 2019;73(5):e35–66.

    Article  CAS  PubMed  Google Scholar 

  35. Roerecke M, Kaczorowski J, Myers MG. Comparing automated office blood pressure readings with other methods of blood pressure measurement for identifying patients with possible hypertension: a systematic review and meta-analysis. JAMA Intern Med. 2019;179(3):351–62.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Stergiou G, Palatini P, Asmar R, de la Sierra A, Myers M, Shennan A, et al. Blood pressure measurement and hypertension diagnosis in the 2017 US guidelines: first things first. Hypertension. 2018;71(6):963–5.

    Article  CAS  PubMed  Google Scholar 

  37. Kallioinen N, Hill A, Horswill MS, Ward HE, Watson MO. Sources of inaccuracy in the measurement of adult patients’ resting blood pressure in clinical settings: a systematic review. J Hypertens. 2017;35(3):421–41.

    Article  CAS  PubMed  Google Scholar 

  38. Johnson KC, Whelton PK, Cushman WC, Cutler JA, Evans GW, Snyder JK, et al. Blood pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial). Hypertension (Dallas, Tex: 1979). 2018;71(5):848–57.

    Article  CAS  Google Scholar 

  39. Ziv A, Vogel O, Keret D, Pintov S, Bodenstein E, Wolkomir K, et al. Comprehensive approach to lower blood pressure (CALM-BP): a randomized controlled trial of a multifactorial lifestyle intervention. J Hum Hypertens. 2013;27(10):594–600.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Cena H, Calder PC. Defining a healthy diet: evidence for the role of contemporary dietary patterns in health and disease. Nutrients. 2020;12(2):334.

    Article  PubMed Central  Google Scholar 

  41. Jennings A, Berendsen AM, de Groot L, Feskens EJM, Brzozowska A, Sicinska E, et al. Mediterranean-style diet improves systolic blood pressure and arterial stiffness in older adults. Hypertension. 2019;73(3):578–86.

    Article  CAS  PubMed  Google Scholar 

  42. Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, et al. Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr. 1995;61(6 Suppl):1402s–6s.

    Article  CAS  PubMed  Google Scholar 

  43. Sacks FM, Campos H. Dietary therapy in hypertension. N Engl J Med. 2010;362(22):2102–12.

    Article  CAS  PubMed  Google Scholar 

  44. Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension. 2006;47(2):296–308.

    Article  CAS  PubMed  Google Scholar 

  45. Blumenthal JA, Babyak MA, Hinderliter A, Watkins LL, Craighead L, Lin PH, et al. Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study. Arch Intern Med. 2010;170(2):126–35.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Lobelo F, Rohm Young D, Sallis R, Garber MD, Billinger SA, Duperly J, et al. Routine assessment and promotion of physical activity in healthcare settings: a scientific statement from the American Heart Association. Circulation. 2018;137(18):e495–522.

    Article  PubMed  Google Scholar 

  47. Saint-Maurice PF, Troiano RP, Bassett DR Jr, Graubard BI, Carlson SA, Shiroma EJ, et al. Association of daily step count and step intensity with mortality among us adults. JAMA. 2020;323(12):1151–60.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Davis C, Bryan J, Hodgson J, Murphy K. Definition of the Mediterranean diet; a literature review. Nutrients. 2015;7(11):9139–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. De Pergola G, D’Alessandro A. Influence of Mediterranean diet on blood pressure. Nutrients. 2018;10(11):1700.

    Article  PubMed Central  CAS  Google Scholar 

  50. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr. 2004;80(4):1012–8.

    Article  CAS  PubMed  Google Scholar 

  51. De Pergola G, Nardecchia A, Guida P, Silvestris F. Arterial hypertension in obesity: relationships with hormone and anthropometric parameters. Eur J Cardiovasc Prev Rehabil. 2011;18(2):240–7.

    Article  PubMed  Google Scholar 

  52. Domenech M, Roman P, Lapetra J, Garcia de la Corte FJ, Sala-Vila A, de la Torre R, et al. Mediterranean diet reduces 24-hour ambulatory blood pressure, blood glucose, and lipids: one-year randomized, clinical trial. Hypertension. 2014;64(1):69–76.

    Article  CAS  PubMed  Google Scholar 

  53. Moreno-Luna R, Munoz-Hernandez R, Miranda ML, Costa AF, Jimenez-Jimenez L, Vallejo-Vaz AJ, et al. Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens. 2012;25(12):1299–304.

    CAS  PubMed  Google Scholar 

  54. Medina-Remon A, Casas R, Tressserra-Rimbau A, Ros E, Martinez-Gonzalez MA, Fito M, et al. Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial. Br J Clin Pharmacol. 2017;83(1):114–28.

    Article  CAS  PubMed  Google Scholar 

  55. Yokoyama Y, Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A, et al. Vegetarian diets and blood pressure: a meta-analysis. JAMA Intern Med. 2014;174(4):577–87.

    Article  PubMed  Google Scholar 

  56. Mitrou PN, Kipnis V, Thiébaut AC, Reedy J, Subar AF, Wirfält E, et al. Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study. Arch Intern Med. 2007;167(22):2461–8.

    Article  PubMed  Google Scholar 

  57. Lopez-Garcia E, Rodriguez-Artalejo F, Li TY, Fung TT, Li S, Willett WC, et al. The Mediterranean-style dietary pattern and mortality among men and women with cardiovascular disease. Am J Clin Nutr. 2014;99(1):172–80.

    Article  CAS  PubMed  Google Scholar 

  58. Tognon G, Lissner L, Sæbye D, Walker KZ, Heitmann BL. The Mediterranean diet in relation to mortality and CVD: a Danish cohort study. Br J Nutr. 2014;111(1):151–9.

    Article  CAS  PubMed  Google Scholar 

  59. Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence and mortality of coronary heart disease and stroke in women. Circulation. 2009;119(8):1093.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Knoops KT, de Groot LC, Kromhout D, Perrin A-E, Moreiras-Varela O, Menotti A, et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA. 2004;292(12):1433–9.

    Article  PubMed  Google Scholar 

  61. Trichopoulou A, Orfanos P, Norat T, Bueno-de-Mesquita B, Ocké MC, Peeters PH, et al. Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. BMJ. 2005;330(7498):991.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Tektonidis TG, Akesson A, Gigante B, Wolk A, Larsson SC. A Mediterranean diet and risk of myocardial infarction, heart failure and stroke: a population-based cohort study. Atherosclerosis. 2015;243(1):93–8.

    Article  CAS  PubMed  Google Scholar 

  63. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA. 2002;288(23):2981–97.

    Google Scholar 

  64. Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009;122(3):290–300.

    Article  PubMed  Google Scholar 

  65. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021–104.

    Article  PubMed  Google Scholar 

  66. Banga S, Mungee S, Patel AR, Singh S, Kizhakekuttu TJ. Management of resistant hypertension based on recommendations from different guidelines and the systolic blood pressure intervention trial. Cureus. 2019;11(8):e5371.

    PubMed  PubMed Central  Google Scholar 

  67. Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, et al. Resistant hypertension: detection, evaluation, and management: a scientific statement from the American Heart Association. Hypertension. 2018;72(5):e53–90.

    Article  CAS  PubMed  Google Scholar 

  68. Bakris GL, Williams M, Dworkin L, Elliott WJ, Epstein M, Toto R, et al. Preserving renal function in adults with hypertension and diabetes: a consensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group. Am J Kidney Dis. 2000;36(3):646–61.

    Article  CAS  PubMed  Google Scholar 

  69. Roush GC, Holford TR, Guddati AK. Chlorthalidone compared with hydrochlorothiazide in reducing cardiovascular events: systematic review and network meta-analyses. Hypertension. 2012;59(6):1110–7.

    Article  CAS  PubMed  Google Scholar 

  70. Pareek AK, Messerli FH, Chandurkar NB, Dharmadhikari SK, Godbole AV, Kshirsagar PP, et al. Efficacy of low-dose chlorthalidone and hydrochlorothiazide as assessed by 24-h ambulatory blood pressure monitoring. J Am Coll Cardiol. 2016;67(4):379–89.

    Article  CAS  PubMed  Google Scholar 

  71. Dineva S, Uzunova K, Pavlova V, Filipova E, Kalinov K, Vekov T. Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis. J Hum Hypertens. 2019;33(11):766–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Chalmers J, Castaigne A, Morgan T, Chastang C. Long-term efficacy of a new, fixed, very-low-dose angiotensin-converting enzyme-inhibitor/diuretic combination as first-line therapy in elderly hypertensive patients. J Hypertens. 2000;18(3):327–37.

    Article  CAS  PubMed  Google Scholar 

  73. Chrysant SG, Fagan T, Glazer R, Kriegman A. Effects of benazepril and hydrochlorothiazide, given alone and in low- and high-dose combinations, on blood pressure in patients with hypertension. Arch Fam Med. 1996;5(1):17–24; discussion 5.

    Article  CAS  PubMed  Google Scholar 

  74. de Leeuw PW, Notter T, Zilles P. Comparison of different fixed antihypertensive combination drugs: a double-blind, placebo-controlled parallel group study. J Hypertens. 1997;15(1):87–91.

    Article  PubMed  Google Scholar 

  75. Meyer BH, Pauly NC. Double-blind comparison of the efficacy and safety of trandolapril 2 mg and hydrochlorothiazide 25 mg in patients with mild-to-moderate essential hypertension. Investigator Study Group. J Cardiovasc Pharmacol. 1994;23 Suppl 4:S77–80.

    Article  CAS  PubMed  Google Scholar 

  76. Muijsers RB, Curran MP, Perry CM. Fixed combination trandolapril/verapamil sustained-release: a review of its use in essential hypertension. Drugs. 2002;62(17):2539–67.

    Article  CAS  PubMed  Google Scholar 

  77. Griebenow R, Pittrow DB, Weidinger G, Mueller E, Mutschler E, Welzel D. Low-dose reserpine/thiazide combination in first-line treatment of hypertension: efficacy and safety compared to an ACE inhibitor. Blood Press. 1997;6(5):299–306.

    Article  CAS  PubMed  Google Scholar 

  78. Jamerson KA, Nwose O, Jean-Louis L, Schofield L, Purkayastha D, Baron M. Initial angiotensin-converting enzyme inhibitor/calcium channel blocker combination therapy achieves superior blood pressure control compared with calcium channel blocker monotherapy in patients with stage 2 hypertension. Am J Hypertens. 2004;17(6):495–501.

    Article  CAS  PubMed  Google Scholar 

  79. DeQuattro V, Lee D. Fixed-dose combination therapy with trandolapril and verapamil SR is effective in primary hypertension. Trandolapril Study Group. Am J Hypertens. 1997;10(7 Pt 2):138s–45s.

    Article  CAS  PubMed  Google Scholar 

  80. Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80%. BMJ. 2003;326(7404):1419.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Munoz D, Uzoije P, Reynolds C, Miller R, Walkley D, Pappalardo S, et al. Polypill for cardiovascular disease prevention in an underserved population. N Engl J Med. 2019;381(12):1114–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373(22):2117–28.

    Article  CAS  PubMed  Google Scholar 

  83. Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375(4):311–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Pladevall M, Brotons C, Gabriel R, Arnau A, Suarez C, de la Figuera M, et al. Multicenter cluster-randomized trial of a multifactorial intervention to improve antihypertensive medication adherence and blood pressure control among patients at high cardiovascular risk (the COM99 study). Circulation. 2010;122(12):1183–91.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Aggarwal B, Mosca L. Lifestyle and psychosocial risk factors predict non-adherence to medication. Ann Behav Med. 2010;40(2):228–33.

    Article  PubMed  Google Scholar 

  86. Jin J, Sklar GE, Min Sen Oh V, Chuen LS. Factors affecting therapeutic compliance: a review from the patient’s perspective. Ther Clin Risk Manag. 2008;4(1):269–86.

    PubMed  PubMed Central  Google Scholar 

  87. Martin MY, Kohler C, Kim YI, Kratt P, Schoenberger YM, Litaker MS, et al. Taking less than prescribed: medication nonadherence and provider-patient relationships in lower-income, rural minority adults with hypertension. J Clin Hypertens (Greenwich). 2010;12(9):706–13.

    Article  Google Scholar 

  88. Norris KC, Tareen N, Martins D, Vaziri ND. Implications of ethnicity for the treatment of hypertensive kidney disease, with an emphasis on African Americans. Nat Clin Pract Nephrol. 2008;4(10):538–49.

    Article  PubMed  Google Scholar 

  89. Duru OK, Vargas RB, Kermah D, Pan D, Norris KC. Health insurance status and hypertension monitoring and control in the United States. Am J Hypertens. 2007;20(4):348–53.

    Article  PubMed  Google Scholar 

  90. Pittman DG, Tao Z, Chen W, Stettin GD. Antihypertensive medication adherence and subsequent healthcare utilization and costs. Am J Manag Care. 2010;16(8):568–76.

    PubMed  Google Scholar 

  91. Autier P, Mullie P, Macacu A, Dragomir M, Boniol M, Coppens K, et al. Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol. 2017;5(12):986–1004.

    Article  CAS  PubMed  Google Scholar 

  92. Schultz WM, Kelli HM, Lisko JC, Varghese T, Shen J, Sandesara P, et al. Socioeconomic status and cardiovascular outcomes: challenges and interventions. Circulation. 2018;137(20):2166–78.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Schnall PL, Schwartz JE, Landsbergis PA, Warren K, Pickering TG. A longitudinal study of job strain and ambulatory blood pressure: results from a three-year follow-up. Psychosom Med. 1998;60(6):697–706.

    Article  CAS  PubMed  Google Scholar 

  94. Landsbergis PA, Diez-Roux AV, Fujishiro K, Baron S, Kaufman JD, Meyer JD, et al. Job strain, occupational category, systolic blood pressure, and hypertension prevalence: the multi-ethnic study of atherosclerosis. J Occup Environ Med. 2015;57(11):1178–84.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Smedley BD, Stith AY, Nelson AR. Institute of Medicine, Committee on Understanding and Eliminating Racial and Ethnic Disparities in Health Care. Unequal treatment: confronting racial and ethnic disparities in healthcare. Washington, DC: National Academies Press; 2003.

    Google Scholar 

  96. Egan BM, Li J, Hutchison FN, Ferdinand KC. Hypertension in the United States, 1999 to 2012: progress toward healthy people 2020 goals. Circulation. 2014;130(19):1692–9.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

This work was supported in part by National Institutes of Health grants P30AG021684 (KN), UL1TR000124 (KN), HHSN26818HV00009R (KN and BB), and R25HL126145 (KN and BB). The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Keith C. Norris .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Norris, K.C., Beech, B.M. (2021). Blood Pressure and Hypertension Management. In: Wong, N.D., Amsterdam, E.A., Toth, P.P. (eds) ASPC Manual of Preventive Cardiology. Contemporary Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-56279-3_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-56279-3_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-56278-6

  • Online ISBN: 978-3-030-56279-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics