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5-HT2B Receptors in Liver

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5-HT2B Receptors

Part of the book series: The Receptors ((REC,volume 35))

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Abstract

The liver has many functions, mainly relating to digestion and detoxification, electrolyte/fluid balancing and haemostasis. Hepatic wound healing is a tightly regulated multi-cellular response to liver injury that stimulates a rapid and efficient repair of the damaged tissue, replacement of lost epithelial cells and restoration of the normal liver architecture and function. Fibrosis is the pathological consequence of chronic liver disease and the accumulation of fibrotic scar tissue impairs liver function, ultimately leading to advanced fibrosis/cirrhosis and increased risk of organ failure or developing liver cancer. In this chapter, we will summarize the important role for serotonin through 5-HT2B receptors reported in hepatocyte proliferation, liver regeneration and fibrosis and in liver metabolic diseases and cancers.

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Abbreviations

BDL:

Bile duct ligation

BECs:

Biliary epithelial cells

CHC:

Chronic hepatitis C

CLD:

Chronic liver disease

ECM:

Extracellular matrix

FFA:

Fatty acids

HM:

Hepatic myofibroblasts

HSC:

Hepatic stellate cells

HCC:

Hepatocellular carcinoma

HFD:

High fat diet

mTOR:

Mammalian target of rapamycin

ERK1:

Mitogen activated protein kinase 1

MAO-A:

Monoamine oxidase A

NAFLD:

Non-alcoholic fatty liver disease

NASH:

Non-alcoholic steatohepatitis

PHx:

Partial hepatectomy

PSC:

Primary sclerosing cholangitis

SERT:

Serotonin transporter

TGF-β1:

Transforming growth factor β1

TG:

Triglyceride

TPH1:

Tryptophan hydroxylase 1

VLDL:

Very low-density lipoprotein

WH:

Wound healing

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Authors and Affiliations

  1. Newcastle Fibrosis Research Group, Bioscience Institute, Newcastle University, Newcastle Upon Tyne, UK

    Lucy Gee & Fiona Oakley

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  1. Lucy Gee
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  2. Fiona Oakley
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Correspondence to Fiona Oakley .

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Editors and Affiliations

  1. Inserm, U1270, Institut du Fer a Moulin, Paris, France

    Luc Maroteaux

  2. Pharmacology, Strasbourg Medical school, Strasbourg, France

    Laurent Monassier

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Gee, L., Oakley, F. (2021). 5-HT2B Receptors in Liver. In: Maroteaux, L., Monassier, L. (eds) 5-HT2B Receptors. The Receptors, vol 35. Springer, Cham. https://doi.org/10.1007/978-3-030-55920-5_14

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