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Acute and Long-Term Effects of Ayahuasca on (Higher-Order) Cognitive Processes

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Ayahuasca Healing and Science

Abstract

There is increasing evidence of the potential therapeutic value of the psychedelic brew ayahuasca for disorders like depression, PTSD, and anxiety. While the focus has been on ayahuasca’s capacity to reduce symptoms of these disorders, including enhancing mood state and well-being, little attention has been paid to the (higher-order) cognitive processes that may be enhanced or that may play a role in this. Examples of such processes include flexible (creative) thinking, empathy, and emotion regulation, which are crucial for everyday interactions and cooperation, and have been found to be decreased in certain pathological populations. The aim of the present chapter is to review the acute and long-term effects of ayahuasca on (higher-order) cognitive processes, such as flexible (creative) thinking, empathy, and emotion regulation, and look for the link between these cognitive effects and subjective mood state and well-being.

Findings show that, although objective evidence is limited due to a scarcity of studies, previous studies with ayahuasca and similar psychedelics, like psilocybin and LSD, support the notion that ayahuasca can enhance previously mentioned higher-order cognitive processes. Importantly, evidence is given to suggest that this enhancement outlasts the acute stage, thus potentially persisting over time. Unfortunately, no study assessed the relationship between these cognitive effects and mood and well-being.

It is concluded that, while these findings partially explain why ayahuasca has therapeutic utility in the treatment of certain psychopathologies, future clinical research into the therapeutic effects of ayahuasca could assess the relationship between the effect on (higher-order) cognitive and emotional processes and mood and well-being and test the role both play in symptom alleviation in the pathological population in the short and longer term.

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References

  • Aldao, A., Nolen-Hoeksema, S., & Schweizer, S. (2010). Emotion-regulation strategies across psychopathology: A meta-analytic review. Clinical Psychology Review, 30(2), 217–237. https://doi.org/10.1016/j.cpr.2009.11.004.

    Article  PubMed  Google Scholar 

  • Amabile, T. M. (1982). Social psychology of creativity: A consensual assessment technique. Journal of Personality and Social Psychology, 43(5), 997–1013. https://doi.org/10.1037/0022-3514.43.5.997.

    Article  Google Scholar 

  • Baas, M., De Dreu, C. K., & Nijstad, B. A. (2008). A meta-analysis of 25 years of mood-creativity research: Hedonic tone, activation, or regulatory focus? Psychological Bulletin, 134(6), 779–806. https://doi.org/10.1037/a0012815.

    Article  PubMed  Google Scholar 

  • Barbosa, P. C., Giglio, J. S., & Dalgalarrondo, P. (2005). Altered states of consciousness and short-term psychological after-effects induced by the first time ritual use of ayahuasca in an urban context in Brazil. Journal of Psychoactive Drugs, 37(2), 193–201. https://doi.org/10.1080/02791072.2005.10399801.

    Article  PubMed  Google Scholar 

  • Barbosa, P. C., Strassman, R. J., da Silveira, D. X., Areco, K., Hoy, R., Pommy, J., Thoma, R., & Bogenschutz, M. (2016). Psychological and neuropsychological assessment of regular hoasca users. Comprehensive Psychiatry, 71, 95–105. https://doi.org/10.1016/j.comppsych.2016.09.003.

    Article  PubMed  Google Scholar 

  • Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001). The “Reading the Mind in the Eyes” test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, 42(2), 241–251. https://doi.org/10.1111/1469-7610.00715.

    Article  CAS  PubMed  Google Scholar 

  • Beketayev, K., & Runco, M. A. (2016). Scoring divergent thinking tests by computer with a semantics-based algorithm. Europe’s Journal of Psychology, 12(2), 210–220. https://doi.org/10.5964/ejop.v12i2.1127.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bickel, P., Dittrich, A., & Schoepf, J. (1976). Altered states of consciousness induced by N,N-dimethyltryptamine (DMT). Pharmakopsychiatr Neuropsychopharmakol, 9(5), 220–225. https://doi.org/10.1055/s-0028-1094495. (Eine experimentelle Untersuchung zur bewusstseinsverandernden Wirkung von N,N-Dimethyltryptamin (DMT)).

    Article  CAS  PubMed  Google Scholar 

  • Bouso, J. C., Doblin, R., Farre, M., Alcazar, M. A., & Gomez-Jarabo, G. (2008). MDMA-assisted psychotherapy using low doses in a small sample of women with chronic posttraumatic stress disorder. Journal of Psychoactive Drugs, 40(3), 225–236. https://doi.org/10.1080/02791072.2008.10400637.

    Article  PubMed  Google Scholar 

  • Bouso, J. C., Gonzalez, D., Fondevila, S., Cutchet, M., Fernandez, X., Ribeiro Barbosa, P. C., Alcazar-Corcoles, M. A., Araujo, W. S., Barbanoj, M. J., Fabregas, J. M., & Riba, J. (2012). Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: A longitudinal study. PLoS One, 7(8), e42421. https://doi.org/10.1371/journal.pone.0042421.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., Hobden, P., Evans, J., Feilding, A., Wise, R. G., & Nutt, D. J. (2012). Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences of the United States of America, 109(6), 2138–2143. https://doi.org/10.1073/pnas.1119598109.

    Article  PubMed  PubMed Central  Google Scholar 

  • Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D. R., & Nutt, D. (2014a). The entropic brain: A theory of conscious states informed by neuroimaging research with psychedelic drugs. Frontiers in Human Neuroscience, 8, 20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Carhart-Harris, R. L., Leech, R., & Tagliazucchi, E. (2014b). How do hallucinogens work on the brain? Journal of Psychophysiology, 71(1), 2–8.

    Google Scholar 

  • Carhart-Harris, R. L., Bolstridge, M., Day, C. M. J., Rucker, J., Watts, R., Erritzoe, D. E., Kaelen, M., Giribaldi, B., Bloomfield, M., Pilling, S., Rickard, J. A., Forbes, B., Feilding, A., Taylor, D., Curran, H. V., & Nutt, D. J. (2017). Psilocybin with psychological support for treatment-resistant depression: Six-month follow-up. Psychopharmacology. https://doi.org/10.1007/s00213-017-4771-x.

  • Chamberlain, S. R., Fineberg, N. A., Blackwell, A. D., Robbins, T. W., & Sahakian, B. J. (2006). Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. The American Journal of Psychiatry, 163(7), 1282–1284. https://doi.org/10.1176/appi.ajp.163.7.1282.

    Article  PubMed  Google Scholar 

  • Chambers, R., Gullone, E., & Allen, N. B. (2009). Mindful emotion regulation: An integrative review. Clinical Psychology Review, 29(6), 560–572. https://doi.org/10.1016/j.cpr.2009.06.005.

    Article  PubMed  Google Scholar 

  • Charuvastra, A., & Cloitre, M. (2008). Social bonds and posttraumatic stress disorder. Annual Review of Psychology, 59, 301–328. https://doi.org/10.1146/annurev.psych.58.110405.085650.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cole, P. M., Michel, M. K., & Teti, L. O. D. (1994). The development of emotion regulation and dysregulation: A clinical perspective. Monographs of the Society for Research in Child Development, 59(2–3), 73–102.

    Article  CAS  PubMed  Google Scholar 

  • Cusi, A. M., Macqueen, G. M., Spreng, R. N., & McKinnon, M. C. (2011). Altered empathic responding in major depressive disorder: Relation to symptom severity, illness burden, and psychosocial outcome. Psychiatry Research, 188(2), 231–236. https://doi.org/10.1016/j.psychres.2011.04.013.

    Article  PubMed  Google Scholar 

  • Da Silveira, D. X., Grob, C. S., de Rios, M. D., Lopez, E., Alonso, L. K., Tacla, C., & Doering-Silveira, E. (2005). Ayahuasca in adolescence: A preliminary psychiatric assessment. Journal of Psychoactive Drugs, 37(2), 129–133. https://doi.org/10.1080/02791072.2005.10399792.

    Article  PubMed  Google Scholar 

  • Dajani, D. R., & Uddin, L. Q. (2015). Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience. Trends in Neurosciences, 38(9), 571–578. https://doi.org/10.1016/j.tins.2015.07.003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Davis, M. H. (1983). Measuring individual differences in empathy: Evidence for a multidimensional approach. Journal of Personality and Social Psychology, 44(1), 113–126. https://doi.org/10.1037/0022-3514.44.1.113.

    Article  Google Scholar 

  • Davis, M. A. (2009). Understanding the relationship between mood and creativity: A meta-analysis. Organizational Behavior and Human Decision Processes, 108(1), 25–38. https://doi.org/10.1016/j.obhdp.2008.04.001.

    Article  Google Scholar 

  • Decety, J. (2011). Dissecting the neural mechanisms mediating empathy. Emotion Review, 3(1), 92–108.

    Article  Google Scholar 

  • Dobkin de Rios, M., & Rumrrill, R. (2009). A hallucinogenic tea, laced with controversy. Ayahuasca in the Amazon and the United States. Journal of Travel Medicine, 16(4), 298–298. https://doi.org/10.1111/j.1708-8305.2009.00325.x.

    Article  Google Scholar 

  • Doering-Silveira, E., Grob, C. S., de Rios, M. D., Lopez, E., Alonso, L. K., Tacla, C., & Da Silveira, D. X. (2005). Report on psychoactive drug use among adolescents using ayahuasca within a religious context. Journal of Psychoactive Drugs, 37(2), 141–144. https://doi.org/10.1080/02791072.2005.10399794.

    Article  PubMed  Google Scholar 

  • Dolder, P. C., Schmid, Y., Müller, F., Borgwardt, S., & Liechti, M. E. (2016). LSD acutely impairs fear recognition and enhances emotional empathy and sociality. Neuropsychopharmacology, 41, 2638. https://doi.org/10.1038/npp.2016.82. https://www.nature.com/articles/npp201682#supplementary-information.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dominguez-Clave, E., Soler, J., Elices, M., Pascual, J. C., Alvarez, E., de la Fuente Revenga, M., Friedlander, P., Feilding, A., & Riba, J. (2016). Ayahuasca: Pharmacology, neuroscience and therapeutic potential. Brain Research Bulletin, 126(Pt 1), 89–101. https://doi.org/10.1016/j.brainresbull.2016.03.002.

    Article  CAS  PubMed  Google Scholar 

  • Domínguez-Clavé, E., Soler, J., Pascual, J. C., Elices, M., Franquesa, A., Valle, M., Alvarez, E., & Riba, J. (2019). Ayahuasca improves emotion dysregulation in a community sample and in individuals with borderline-like traits. Psychopharmacology, 236(2), 573–580.

    Article  PubMed  Google Scholar 

  • Dominguez-Clavé, E., Elices, M., Morales Garcia, J. A., Pascual, J. C., Soler, J., Pérez-Castillo, A., & Riba, J. (2021). Ayahuasca as an unusually versatile therapeutic agent: From molecules to meta-cognition and back. In B. C. Labate & C. Cavnar (Eds.), Ayahuasca healing and science. in this volume.

    Google Scholar 

  • Donges, U. S., Kersting, A., Dannlowski, U., Lalee-Mentzel, J., Arolt, V., & Suslow, T. (2005). Reduced awareness of others’ emotions in unipolar depressed patients. The Journal of Nervous and Mental Disease, 193(5), 331–337.

    Article  PubMed  Google Scholar 

  • Dos Santos, R. G., Osorio, F. L., Crippa, J. A., & Hallak, J. E. (2016a). Antidepressive and anxiolytic effects of ayahuasca: A systematic literature review of animal and human studies. Revista Brasileira de Psiquiatria, 38(1), 65–72. https://doi.org/10.1590/1516-4446-2015-1701.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dos Santos, R. G., Osório, F. L., Crippa, J. A. S., Riba, J., Zuardi, A. W., & Hallak, J. E. C. (2016b). Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): A systematic review of clinical trials published in the last 25 years. Therapeutic Advances in Psychopharmacology, 6(3), 193–213. https://doi.org/10.1177/2045125316638008.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dziobek, I., Rogers, K., Fleck, S., Bahnemann, M., Heekeren, H. R., Wolf, O. T., & Convit, A. (2008). Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET) [journal article]. Journal of Autism and Developmental Disorders, 38(3), 464–473. https://doi.org/10.1007/s10803-007-0486-x.

    Article  PubMed  Google Scholar 

  • Fantegrossi, W. E., Murnane, K. S., & Reissig, C. J. (2008). The behavioral pharmacology of hallucinogens. Biochemical Pharmacology, 75(1), 17–33. https://doi.org/10.1016/j.bcp.2007.07.018.

    Article  CAS  PubMed  Google Scholar 

  • Farb, N. A. S., Anderson, A. K., & Segal, Z. V. (2012). The mindful brain and emotion regulation in mood disorders. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 57(2), 70–77. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303604/.

    Article  PubMed  Google Scholar 

  • Forgeard, M. J. C., & Elstein, J. G. (2014). Advancing the clinical science of creativity. Frontiers in Psychology, 5, 613. https://doi.org/10.3389/fpsyg.2014.00613.

    Article  PubMed  PubMed Central  Google Scholar 

  • Franquesa, A., Sainz-Cort, A., Gandy, S., Soler, J., Alcázar-Córcoles, M. Á., & Bouso, J. C. (2018). Psychological variables implied in the therapeutic effect of ayahuasca: A contextual approach. Psychiatry Research, 264, 334–339.

    Article  PubMed  Google Scholar 

  • Frecska, E., More, C. E., Vargha, A., & Luna, L. E. (2012). Enhancement of creative expression and entoptic phenomena as after-effects of repeated ayahuasca ceremonies. Journal of Psychoactive Drugs, 44(3), 191–199. https://doi.org/10.1080/02791072.2012.703099.

  • Frecska, E., Bokor, P., & Winkelman, M. (2016). The therapeutic potentials of ayahuasca: Possible effects against various diseases of civilization. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00035.

  • Goldin, P. R., McRae, K., Ramel, W., & Gross, J. J. (2008). The neural bases of emotion regulation: Reappraisal and suppression of negative emotion. Biological Psychiatry, 63(6), 577–586.

    Article  PubMed  Google Scholar 

  • Grattan, L. M., & Eslinger, P. J. (1989). Higher cognition and social behavior: Changes in cognitive flexibility and empathy after cerebral lesions. Neuropsychology, 3(3), 175–185. https://doi.org/10.1037/h0091764.

    Article  Google Scholar 

  • Gratz, K. L., & Roemer, L. (2004). Multidimensional assessment of emotion regulation and dysregulation: Development, factor structure, and initial validation of the difficulties in emotion regulation scale. Journal of Psychopathology and Behavioral Assessment, 26(1), 41–54.

    Article  Google Scholar 

  • Griffiths, R. R., Richards, W. A., McCann, U., & Jesse, R. (2006). Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 187(3), 268–283; discussion 284–292. https://doi.org/10.1007/s00213-006-0457-5.

    Article  CAS  PubMed  Google Scholar 

  • Grob, C. S., McKenna, D. J., Callaway, J. C., Brito, G. S., Neves, E. S., Oberlaender, G., Saide, O. L., Labigalini, E., Tacla, C., Miranda, C. T., Strassman, R. J., & Boone, K. B. (1996). Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. The Journal of Nervous and Mental Disease, 184(2), 86–94.

    Article  CAS  PubMed  Google Scholar 

  • Gross, J. J. (1998). The emerging field of emotion regulation: An integrative review. Review of General Psychology, 2(3), 271–299.

    Article  Google Scholar 

  • Gross, J. J., & Muñoz, R. F. (1995). Emotion regulation and mental health. Clinical Psychology: Science and Practice, 2(2), 151–164.

    Google Scholar 

  • Gyurak, A., Gross, J. J., & Etkin, A. (2011). Explicit and implicit emotion regulation: A dual-process framework. Cognition & Emotion, 25(3), 400–412. https://doi.org/10.1080/02699931.2010.544160.

    Article  Google Scholar 

  • Harman, W. W., McKim, R. H., Mogar, R. E., Fadiman, J., & Stolaroff, M. J. (1966). Psychedelic agents in creative problem-solving: A pilot study. Psychological Reports, 19(1), 211–227.

    Article  CAS  PubMed  Google Scholar 

  • Hasler, F., Grimberg, U., Benz, M. A., Huber, T., & Vollenweider, F. X. (2004). Acute psychological and physiological effects of psilocybin in healthy humans: A double-blind, placebo-controlled dose-effect study. Psychopharmacology, 172(2), 145–156. https://doi.org/10.1007/s00213-003-1640-6.

    Article  CAS  PubMed  Google Scholar 

  • Hayes, A. M., & Feldman, G. (2004). Clarifying the construct of mindfulness in the context of emotion regulation and the process of change in therapy. Clinical Psychology: Science and Practice, 11(3), 255–262. https://doi.org/10.1093/clipsy.bph080.

    Article  Google Scholar 

  • Hendricks, P. S., Thorne, C. B., Clark, C. B., Coombs, D. W., & Johnson, M. W. (2015). Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. Journal of Psychopharmacology, 29(3), 280–288. https://doi.org/10.1177/0269881114565653.

    Article  CAS  PubMed  Google Scholar 

  • Hysek, C. M., Simmler, L. D., Schillinger, N., Meyer, N., Schmid, Y., Donzelli, M., Grouzmann, E., & Liechti, M. E. (2014). Pharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination. The International Journal of Neuropsychopharmacology, 17(3), 371–381. https://doi.org/10.1017/s1461145713001132.

    Article  CAS  PubMed  Google Scholar 

  • Iszáj, F., Griffiths, M. D., & Demetrovics, Z. (2017). Creativity and psychoactive substance use: A systematic review. International Journal of Mental Health and Addiction, 15(5), 1135–1149. https://doi.org/10.1007/s11469-016-9709-8.

    Article  Google Scholar 

  • Joormann, J., & Gotlib, I. H. (2010). Emotion regulation in depression: Relation to cognitive inhibition. Cognition and Emotion, 24(2), 281–298.

    Article  PubMed  Google Scholar 

  • Kemmis, L., Hall, J. K., Kingston, R., & Morgan, M. J. (2007). Impaired fear recognition in regular recreational cocaine users [journal article]. Psychopharmacology (Berl), 194(2), 151–159. https://doi.org/10.1007/s00213-007-0829-5.

    Article  CAS  Google Scholar 

  • Kjellgren, A., Eriksson, A., & Norlander, T. (2009). Experiences of encounters with ayahuasca “the vine of the soul”. Journal of Psychoactive Drugs, 41(4), 309–315. https://doi.org/10.1080/02791072.2009.10399767.

    Article  PubMed  Google Scholar 

  • Krippner, S. (1968). The psychedelic state, the hypnotic trance, and the creative act. Journal of Humanistic Psychology, 8(1), 49–67.

    Article  Google Scholar 

  • Kuypers, K. P. C., de la Torre, R., Farre, M., Yubero-Lahoz, S., Dziobek, I., Van den Bos, W., & Ramaekers, J. G. (2014). No evidence that MDMA-induced enhancement of emotional empathy is related to peripheral oxytocin levels or 5-HT1a receptor activation. PLoS One, 9(6), e100719. https://doi.org/10.1371/journal.pone.0100719.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kuypers, K. P. C., Riba, J., de la Fuente Revenga, M., Barker, S., Theunissen, E. L., & Ramaekers, J. G. (2016). Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking. Psychopharmacology (Berl), 233(18), 3395–3403. https://doi.org/10.1007/s00213-016-4377-8.

    Article  CAS  Google Scholar 

  • Kuypers, K. P. C., Dolder, P. C., Ramaekers, J. G., & Liechti, M. E. (2017). Multifaceted empathy of healthy volunteers after single doses of MDMA: A pooled sample of placebo-controlled studies. Journal of Psychopharmacology, 31(5), 589–598. https://doi.org/10.1177/0269881117699617.

    Article  CAS  PubMed  Google Scholar 

  • Lafrance, A., Loizaga-Velder, A., Fletcher, J., Renelli, M., Files, N., & Tupper, K. W. (2017). Nourishing the spirit: Exploratory research on ayahuasca experiences along the continuum of recovery from eating disorders. Journal of Psychoactive Drugs, 49(5), 427–435.

    Article  PubMed  Google Scholar 

  • Lawn, W., Hallak, J. E., Crippa, J. A., Dos Santos, R., Porffy, L., Barratt, M. J., Ferris, J. A., Winstock, A. R., & Morgan, C. J. A. (2017). Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: A large, international, self-selecting online survey. Scientific Reports, 7(1), 15201. https://doi.org/10.1038/s41598-017-14700-6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Leary, T., Litwin, G. H., & Metzner, R. (1963). Reactions to psilocybin administered in a supportive environment. The Journal of Nervous and Mental Disease, 137, 561–573.

    Article  CAS  PubMed  Google Scholar 

  • Luna, L. E. (2011). Indigenous and mestizo use of ayahuasca. An overview. In R. G. Santos (Ed.), The ethnopharmacology of ayahuasca (pp. 1–19). Trivandrum: Transworld Research Network.

    Google Scholar 

  • Mason, N. L., Mischler, E., Uthaug, M. V., & Kuypers, K. P. (2019). Sub-acute effects of psilocybin on empathy, creative thinking, and subjective well-being. Journal of Psychoactive Drugs, 51(2), 123–134.

    Article  PubMed  Google Scholar 

  • McKenna, D. J. (2004). Clinical investigations of the therapeutic potential of ayahuasca: Rationale and regulatory challenges. Pharmacology & Therapeutics, 102(2), 111–129. https://doi.org/10.1016/j.pharmthera.2004.03.002.

    Article  CAS  Google Scholar 

  • McKenna, D. J., Towers, G. H., & Abbott, F. (1984). Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and beta-carboline constituents of ayahuasca. Journal of Ethnopharmacology, 10(2), 195–223.

    Article  CAS  PubMed  Google Scholar 

  • McRae, K., Ochsner, K. N., Mauss, I. B., Gabrieli, J. J., & Gross, J. J. (2008). Gender differences in emotion regulation: An fMRI study of cognitive reappraisal. Group Processes & Intergroup Relations, 11(2), 143–162.

    Article  Google Scholar 

  • Narby, J., & Huxley, F. (2004). Shamans through time. New York City: Penguin.

    Google Scholar 

  • Nietlisbach, G., Maercker, A., Rossler, W., & Haker, H. (2010). Are empathic abilities impaired in posttraumatic stress disorder? Psychological Reports, 106(3), 832–844. https://doi.org/10.2466/pr0.106.3.832-844.

    Article  PubMed  Google Scholar 

  • Nunes, A. A., dos Santos, R. G., Osório, F. L., Sanches, R. F., Crippa, J. A. S., & Hallak, J. E. (2016). Effects of ayahuasca and its alkaloids on drug dependence: A systematic literature review of quantitative studies in animals and humans. Journal of Psychoactive Drugs, 48(3), 195–205.

    Article  PubMed  Google Scholar 

  • Nutt, D. J. (2012). Drugs – without the hot air: Minimising the harms of legal and illegal drugs. Cambridge: UIT Cambridge.

    Google Scholar 

  • Ochsner, K. N., Silvers, J. A., & Buhle, J. T. (2012). Functional imaging studies of emotion regulation: A synthetic review and evolving model of the cognitive control of emotion. Annals of the New York Academy of Sciences, 1251, E1.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oehen, P., Traber, R., Widmer, V., & Schnyder, U. (2013). A randomized, controlled pilot study of MDMA (+/− 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic post-traumatic stress disorder (PTSD). Journal of Psychopharmacology, 27(1), 40–52. https://doi.org/10.1177/0269881112464827.

    Article  CAS  PubMed  Google Scholar 

  • Osorio, F. L., Sanches, R. F., Macedo, L. R., Santos, R. G., Maia-de-Oliveira, J. P., Wichert-Ana, L., Araujo, D. B., Riba, J., Crippa, J. A., & Hallak, J. E. (2015). Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: A preliminary report. Revista Brasileira de Psiquiatria, 37(1), 13–20. https://doi.org/10.1590/1516-4446-2014-1496.

    Article  Google Scholar 

  • Palhano-Fontes, F., Andrade, K. C., Tofoli, L. F., Santos, A. C., Crippa, J. A., Hallak, J. E., Ribeiro, S., & de Araujo, D. B. (2015). The psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network. PLoS One, 10(2), e0118143. https://doi.org/10.1371/journal.pone.0118143.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Palhano-Fontes, F., Onias, H., Novaes, M., Andrade, K. C., Arcoverde, E., Maia-de-Oliveira, J. P., & de Araújo, D. B. (2017). Emotion processing and the antidepressant effects of ayahuasca in treatment-resistant depression: An fMRI study. Os efeitos antidepressivos da ayahuasca, suas bases neurais e relação com a experiência psicodélica, 94.

    Google Scholar 

  • Palhano-Fontes, F., Barreto, D., Onias, H., Andrade, K. C., Novaes, M. M., Pessoa, J. A., Mota-Rolim, S. A., Osorio, F. L., Sanches, R., Dos Santos, R. G., Tofoli, L. F., de Oliveira Silveira, G., Yonamine, M., Riba, J., Santos, F. R., Silva-Junior, A. A., Alchieri, J. C., Galvao-Coelho, N. L., Lobao-Soares, B., Hallak, J. E. C., Arcoverde, E., Maia-de-Oliveira, J. P., & Araujo, D. B. (2019). Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: A randomized placebo-controlled trial. Psychological Medicine, 49(4), 655–663. https://doi.org/10.1017/s0033291718001356.

    Article  PubMed  PubMed Central  Google Scholar 

  • Palhano-Fontes, F., Mota-Rolim, S. A., Lobao-Soares, B., Galvao-Coelho, N. L., Maia-de-Oliveira, J. P., & Araujo, D. B. (2021). New evidence of the antidepressant effects of ayahuasca. In B. C. Labate & C. Cavnar (Eds.), Ayahuasca healing and science, in this volume.

    Google Scholar 

  • Parlar, M., Frewen, P., Nazarov, A., Oremus, C., MacQueen, G., Lanius, R., & McKinnon, M. C. (2014). Alterations in empathic responding among women with posttraumatic stress disorder associated with childhood trauma. Brain and Behavior: A Cognitive Neuroscience Perspective, 4(3), 381–389. https://doi.org/10.1002/brb3.215.

    Article  Google Scholar 

  • Pokorny, T., Preller, K. H., Kometer, M., Dziobek, I., & Vollenweider, F. X. (2017). Effect of psilocybin on empathy and moral decision-making. International Journal of Neuropsychopharmacology, 20(9), 747–757. https://doi.org/10.1093/ijnp/pyx047.

    Article  PubMed Central  PubMed  Google Scholar 

  • Preller, K., Pokorny, T., Krähenmann, R., Dziobek, I., Stämpfli, P., & Vollenweider, F. (2015). The effect of 5-HT2A/1a agonist treatment on social cognition, empathy, and social decision-making. European Psychiatry, 30, 22.

    Article  Google Scholar 

  • Prochazkova, L., Lippelt, D. P., Colzato, L. S., Kuchar, M., Sjoerds, Z., & Hommel, B. (2018). Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting. Psychopharmacology, 235(12), 3401–3413.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Riba, J., Rodriguez-Fornells, A., Urbano, G., Morte, A., Antonijoan, R., Montero, M., Callaway, J. C., & Barbanoj, M. J. (2001). Subjective effects and tolerability of the south American psychoactive beverage ayahuasca in healthy volunteers. Psychopharmacology, 154(1), 85–95.

    Article  CAS  PubMed  Google Scholar 

  • Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003). Human pharmacology of ayahuasca: Subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics. The Journal of Pharmacology and Experimental Therapeutics, 306(1), 73–83. https://doi.org/10.1124/jpet.103.049882.

    Article  CAS  PubMed  Google Scholar 

  • Riba, J., Romero, S., Grasa, E., Mena, E., Carrio, I., & Barbanoj, M. J. (2006). Increased frontal and paralimbic activation following ayahuasca, the pan-Amazonian inebriant. Psychopharmacology, 186(1), 93–98. https://doi.org/10.1007/s00213-006-0358-7.

    Article  CAS  PubMed  Google Scholar 

  • Roemer, L., Williston, S. K., & Rollins, L. G. (2015). Mindfulness and emotion regulation. Current Opinion in Psychology, 3, 52–57.

    Article  Google Scholar 

  • Runco, M. A., & Acar, S. (2012). Divergent thinking as an indicator of creative potential. Creativity Research Journal, 24(1), 66–75. https://doi.org/10.1080/10400419.2012.652929.

    Article  Google Scholar 

  • Sampedro, F., de la Fuente Revenga, M., Valle, M., Roberto, N., Domínguez-Clavé, E., Elices, M., Luna, L. E., Crippa, J. A. S., Hallak, J. E., & de Araujo, D. B. (2017). Assessing the psychedelic “after-glow” in ayahuasca users: Post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacities. International Journal of Neuropsychopharmacology, 20(9), 698–711. https://doi.org/10.1093/ijnp/pyx036.

    Article  PubMed Central  PubMed  Google Scholar 

  • Sanches, R. F., de Lima Osorio, F., Dos Santos, R. G., Macedo, L. R., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A., & Hallak, J. E. (2016). Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: A SPECT study. Journal of Clinical Psychopharmacology, 36(1), 77–81. https://doi.org/10.1097/jcp.0000000000000436.

    Article  CAS  PubMed  Google Scholar 

  • Santos, R. G., Landeira-Fernandez, J., Strassman, R. J., Motta, V., & Cruz, A. P. (2007). Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members. Journal of Ethnopharmacology, 112(3), 507–513. https://doi.org/10.1016/j.jep.2007.04.012.

    Article  CAS  PubMed  Google Scholar 

  • Schipper, M., & Petermann, F. (2013). Relating empathy and emotion regulation: Do deficits in empathy trigger emotion dysregulation? Social Neuroscience, 8(1), 101–107. https://doi.org/10.1080/17470919.2012.761650.

    Article  PubMed  Google Scholar 

  • Schmid, Y., Hysek, C. M., Simmler, L. D., Crockett, M. J., Quednow, B. B., & Liechti, M. E. (2014). Differential effects of MDMA and methylphenidate on social cognition. Journal of Psychopharmacology, 28(9), 847–856. https://doi.org/10.1177/0269881114542454.

    Article  CAS  PubMed  Google Scholar 

  • Schultes, R. G., & Hofmann, A. (1979). Plants of the gods: Origins of hallucinogenic use. New York: McGraw-Hill.

    Google Scholar 

  • Sessa, B. (2008). Is it time to revisit the role of psychedelic drugs in enhancing human creativity? Journal of Psychopharmacology, 22(8), 821–827. https://doi.org/10.1177/0269881108091597.

    Article  CAS  PubMed  Google Scholar 

  • Shanon, B. (2000). Ayahuasca and creativity. MAPS Newsletter, 10(3), 18–19. https://maps.org/news-letters/v10n3/10318sha.pdf.

    Google Scholar 

  • Shewan, D., Dalgarno, P., & Reith, G. (2000). Perceived risk and risk reduction among ecstasy users: The role of drug, set, and setting. International Journal of Drug Policy, 10(6), 431–453.

    Article  Google Scholar 

  • Sloan, D. M. (2004). Emotion regulation in action: Emotional reactivity in experiential avoidance. Behaviour Research and Therapy, 42(11), 1257–1270. https://doi.org/10.1016/j.brat.2003.08.006.

    Article  PubMed  Google Scholar 

  • Smith, R. L., Canton, H., Barrett, R. J., & Sanders-Bush, E. (1998). Agonist properties of N,N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors. Pharmacology, Biochemistry, and Behavior, 61(3), 323–330.

    Article  CAS  PubMed  Google Scholar 

  • Soler, J., Elices, M., Franquesa, A., Barker, S., Friedlander, P., Feilding, A., Pascual, J. C., & Riba, J. (2016). Exploring the therapeutic potential of ayahuasca: Acute intake increases mindfulness-related capacities. Psychopharmacology (Berl), 233(5), 823–829. https://doi.org/10.1007/s00213-015-4162-0.

    Article  CAS  Google Scholar 

  • Tagliazucchi, E., Carhart-Harris, R. L., Leech, R., Nutt, D., & Chialvo, D. R. (2014). Enhanced repertoire of brain dynamical states during the psychedelic experience. Human Brain Mapping, 35(11), 5442–5456. https://doi.org/10.1002/hbm.22562.

    Article  PubMed  PubMed Central  Google Scholar 

  • Thomas, G., Lucas, P., Capler, N. R., Tupper, K. W., & Martin, G. (2013). Ayahuasca-assisted therapy for addiction: Results from a preliminary observational study in Canada. Current Drug Abuse Reviews, 6(1), 30–42.

    Article  PubMed  Google Scholar 

  • Todd, A. R., Forstmann, M., Burgmer, P., Brooks, A. W., & Galinsky, A. D. (2015). Anxious and egocentric: How specific emotions influence perspective taking. Journal of Experimental Psychology. General, 144(2), 374–391. https://doi.org/10.1037/xge0000048.

    Article  PubMed  Google Scholar 

  • Tull, M. T., Barrett, H. M., McMillan, E. S., & Roemer, L. (2007). A preliminary investigation of the relationship between emotion regulation difficulties and posttraumatic stress symptoms. Behavior Therapy, 38(3), 303–313. https://doi.org/10.1016/j.beth.2006.10.001.

    Article  PubMed  Google Scholar 

  • Tupper, K. W. (2009). Ayahuasca healing beyond the Amazon: The globalization of a traditional indigenous entheogenic practice. Global Networks, 9(1), 117–136. https://doi.org/10.1111/j.1471-0374.2009.00245.x.

    Article  Google Scholar 

  • Uthaug, M. V., van Oorsouw, K., Kuypers, K. P. C., van Boxtel, M., Broers, N. J., Mason, N. L., Toennes, S. W., Riba, J., & Ramaekers, J. G. (2018). Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution. Psychopharmacology, 235(10): 2979–2989.

    Google Scholar 

  • Uthaug, M. V., Lancelotta, R., van Oorsouw, K., Kuypers, K., Mason, N., Rak, J., Šuláková, A., Jurok, R., Maryška, M., & Kuchař, M. (2019). A single inhalation of vapor from dried toad secretion containing 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology (Berl), 236(9):2653–2666.

    Google Scholar 

  • Visted, E., Sørensen, L., Osnes, B., Svendsen, J. L., Binder, P.-E., & Schanche, E. (2017). The association between self-reported difficulties in emotion regulation and heart rate variability: The salient role of not accepting negative emotions. Frontiers in Psychology, 8, 328. https://doi.org/10.3389/fpsyg.2017.00328.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vollenweider, F. X., & Kometer, M. (2010). The neurobiology of psychedelic drugs: Implications for the treatment of mood disorders. Nature Reviews. Neuroscience, 11(9), 642–651. https://doi.org/10.1038/nrn2884.

    Article  CAS  PubMed  Google Scholar 

  • Williams, D. P., Cash, C., Rankin, C., Bernardi, A., Koenig, J., & Thayer, J. F. (2015). Resting heart rate variability predicts self-reported difficulties in emotion regulation: A focus on different facets of emotion regulation. Frontiers in Psychology, 6, 261. https://doi.org/10.3389/fpsyg.2015.00261.

    Article  PubMed  PubMed Central  Google Scholar 

  • Winkelman, M. (2005). Drug tourism or spiritual healing? Ayahuasca seekers in Amazonia. Journal of Psychoactive Drugs, 37(2), 209–218. https://doi.org/10.1080/02791072.2005.10399803.

    Article  PubMed  Google Scholar 

  • Zeifman, R., Palhano-Fontes, F., Hallak, J., Nunes, E. A., Maia-de-Oliveira, J. P., & de Araujo, D. B. (2019). The impact of ayahuasca on suicidality: Results from a randomized controlled trial. Frontiers in Pharmacology, 10, 1325.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands

    Natasha L. Mason & Kim P. C. Kuypers

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  1. Chacruna Institute for Psychedelic Plant Medicines, San Francisco, CA, USA

    Beatriz Caiuby Labate

  2. Chacruna Institute for Psychedelic Plant Medicines, San Francisco, CA, USA

    Clancy Cavnar

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Mason, N.L., Kuypers, K.P.C. (2021). Acute and Long-Term Effects of Ayahuasca on (Higher-Order) Cognitive Processes. In: Labate, B.C., Cavnar, C. (eds) Ayahuasca Healing and Science. Springer, Cham. https://doi.org/10.1007/978-3-030-55688-4_7

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