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Inwardly Rectifying K+ Channel 4.1 Regulates Renal K+ Excretion in the Aldosterone-Sensitive Distal Nephron

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Studies of Epithelial Transporters and Ion Channels

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

The inwardly rectifying potassium channel 4.1 (Kir4.1, KCNJ10) in the aldosterone-sensitive distal nephron (ASDN) plays a key role in the regulation of Na+ and K+ transport by sensing the dietary K+ and Na+ intake. The K+ channel is also the target for angiotensin II, bradykinin, and norepinephrine which are known to regulate the renal Na+ and K+ transport in the ASDN. Since Kir4.1 plays a critical role in the regulation of renal K+ excretion and in maintaining K+ homeostasis, the main focus of this chapter is to review the role of Kir4.1 in the regulation of renal K+ excretion. Finally, because Kir4.1/Kir5.1 (encoded by KCNJ16) heterotetramer is a more physiologically relevant form of the K+ channel in the ASDN than Kir4.1 homotetramer, the role of the Kir4.1/Kir5.1 heterotetramer in the regulation of membrane transport is discussed in the chapter together with Kir4.1 homotetramer.

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Acknowledgments

This work is supported by NIH grant DK 54983 (WHW) and DK 115366 (LDH). The author thanks Ms. Gail Anderson for editing the manuscript.

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  1. Department of Pharmacology, New York Medical College, Valhalla, NY, USA

    Wen-Hui Wang & Dao-Hong Lin

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  1. Wen-Hui Wang
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Correspondence to Wen-Hui Wang .

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  1. Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand

    Kirk L. Hamilton

  2. Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA

    Daniel C. Devor

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Wang, WH., Lin, DH. (2020). Inwardly Rectifying K+ Channel 4.1 Regulates Renal K+ Excretion in the Aldosterone-Sensitive Distal Nephron. In: Hamilton, K.L., Devor, D.C. (eds) Studies of Epithelial Transporters and Ion Channels. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-55454-5_20

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