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H,K-ATPases in Epithelia

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Studies of Epithelial Transporters and Ion Channels

Part of the book series: Physiology in Health and Disease ((PIHD))

Abstract

H,K-ATPases are plasma membrane ion pumps belonging to the P-type ATPase family. They are involved in multiple physiological functions, mainly through their activity of moving protons out of epithelial cells in exchange for K+. There are two types of H,K-ATPases: type 1 is predominantly expressed in the stomach and corresponds to a ‘pure’ H,K-ATPase; type 2 has a broader tissue distribution and a more versatile ion selectivity. In this chapter, we will discuss in detail the functional and pharmacological characteristics of these ATPases and their physiological roles in the organism.

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Acknowledgements

GC has been supported by a ‘Fondation pour la Recherche Médicale’ grant (DPC20171138949). I dedicate this chapter to my mentors Käthi Geering and Jean-Daniel Horisberger, passed away too early, who introduced me in science and shared with me their passion for ion transport and ion pumps during my PhD training and post-doctoral fellowship at the University of Lausanne, Switzerland.

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  1. Laboratoire de Physiologie Rénale et Tubulopathies, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France

    Gilles Crambert

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Correspondence to Gilles Crambert .

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  1. Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand

    Kirk L. Hamilton

  2. Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA

    Daniel C. Devor

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Crambert, G. (2020). H,K-ATPases in Epithelia. In: Hamilton, K.L., Devor, D.C. (eds) Studies of Epithelial Transporters and Ion Channels. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-55454-5_10

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