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Neuropsychiatric Symptoms in Neuro-Behçet’s Disease

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Neuro-Behçet’s Disease

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Abstract

Cognitive and psychiatric aspects of neuro-Behçet’s disease remain obscure despite considerable research. The complicated and yet unrevealed pathophysiology contributes to the puzzling nature of the process. Predominant involvement of the brainstem and diencephalic regions may result in significant neurological disability along with dysfunction in higher intellectual functions. Several studies reported variable cognitive and psychiatric involvement profiles, although having some common features. Patients predominantly have attention deficit and frontal executive dysfunction, primary and secondary memory impairment, and even personality changes. Several psychiatric symptoms, such as depression, anxiety, mood disorders, and psychosis may be encountered. However, heterogeneous study designs make it difficult to interpret the results and to draw a clear-cut conclusion. Interestingly, some magnetic resonance imaging (MRI) and single-photon emission computerized tomography (SPECT) studies revealed apparent abnormalities in specific brain regions that were unaffected by the disease process, which may be associated with the occurrence of neuropsychiatric symptoms. Neuropsychological profiles and SPECT findings in patients with isolated cerebellar and brainstem involvement show striking similarities with neuro-Behçet’s disease patients, which requires more extensive research studies in the future.

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Authors and Affiliations

  1. Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Tuncay Gündüz

  2. Department of Psychiatry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Erhan Ertekin

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  1. Tuncay Gündüz
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  2. Erhan Ertekin
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Editors and Affiliations

  1. Istanbul University, Istanbul, Turkey

    Erdem Tüzün

  2. Istanbul University, Istanbul, Turkey

    Murat Kürtüncü

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Gündüz, T., Ertekin, E. (2021). Neuropsychiatric Symptoms in Neuro-Behçet’s Disease. In: Tüzün, E., Kürtüncü, M. (eds) Neuro-Behçet’s Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-55273-2_11

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