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Organ Preservation

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Transplantation Surgery

Part of the book series: Springer Specialist Surgery Series ((SPECIALIST))

Abstract

Since the first speculations about organ preservation over 200 years ago, there has been enormous progress in this field. Progressin solid-organ transplantation from the level of experimental studies to becoming the criterion standard is undoubtedly due to advances in organ retrieval from deceased donors and their preservation. The objective of the preservation process is to preserve organ function and cellular integrity until the time of transplant. Because the number of patients on wait lists has increased and because of the limited organ and tissue pool, marginal grafts from deceased donors have become more frequently used. In this regard, organ and tissue preservation techniques are of even greater importance for outcomes attained with marginal grafts. In this chapter, we will review and discuss injury mechanisms during the organ preservation process, the history of organ preservation techniques and solutions and currently used practices, and future perspectives. These techniques have initiated in-depth studies about advanced graft preservation, viability assessment, and most importantly repair and regeneration. Studies on organ preservation continue intensively in many organ transplant centers worldwide, with the basic aim of prolonging preservation time without injuring the organ.

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Authors and Affiliations

  1. Division of Transplantation, Department of General Surgery, Baskent University, Ankara, Turkey

    Mahir Kirnap & Mehmet Haberal

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  1. Mahir Kirnap
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  2. Mehmet Haberal
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Correspondence to Mehmet Haberal .

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  1. Imperial College London, London, UK

    Nadey Hakim

  2. Başkent University, Ankara, Turkey

    Mehmet Haberal

  3. University of Virginia Medical Center, Charlottesville, VA, USA

    Daniel Maluf

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Kirnap, M., Haberal, M. (2021). Organ Preservation. In: Hakim, N., Haberal, M., Maluf, D. (eds) Transplantation Surgery. Springer Specialist Surgery Series. Springer, Cham. https://doi.org/10.1007/978-3-030-55244-2_6

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  • DOI: https://doi.org/10.1007/978-3-030-55244-2_6

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