Abstract
Brain tumors can be classified as primary if they originate from intracranial elements, and secondary if they originate from another organ, as metastases. The global prevalence of central nervous system (CNS) neoplasms in 5 years is approximately 771,110 cases. Primary brain tumors represent 1.7% of all cancers and global incidence is 3.9 per 100,000 person-years for all central nervous system tumors; this incidence varies from age, gender, race and region, with higher frequency in Northern Europe, followed by Australia, United States and Canada. African-Americans show higher incidence of benign neoplasms, whereas Caucasian individuals show a higher rate of malignant neoplasms incidence. Central nervous system neoplasms are more frequent in women with meningiomas having the most significant difference. In primary brain tumors, meningiomas are the most frequent, representing 36.8% of all neoplasms; gliomas are the most common malignant type, representing 75% of the malignant central nervous system tumors, with a global incidence of 6 per 100,000 person-years. Global mortality of CNS neoplasms represents 2.71% of all deaths by cancer. The only risk factors confirmed for brain tumors are associated with ionizing radiation and hereditary cancer, such as phakomatosis syndromes (neurofibromatosis, tuberous sclerosis, von Hippel-Lindau’s, Gorlin’s, and Cowden’s) and other hereditary cancer syndromes (Lynch and Li-Fraumeni). Mortality tends to be higher in adults than in the child population. The 5-year survival rate for anaplastic astrocytoma is 30% and for glioblastoma (GB) is 5.6%, the 10-year survival rate for patients with glioblastoma is 0.71%. This chapter focuses on the epidemiological basis of brain tumors.
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References
Lapointe S, Perry A, Butowski NA. Primary brain tumours in adults. Lancet. 2018;392(10145):432–46. https://doi.org/10.1016/S0140-6736(18)30990-5.
De Robles P, Fiest KM, Frolkis AD, Pringsheim T, Atta C, St. Germaine-Smith C, Day L, Lam D, Jette N. The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis. Neuro-Oncology. 2015;17(6):776–83. https://doi.org/10.1093/neuonc/nou283.
Porter KR, McCarthy BJ, Freels S, Kim Y, Davis FG. Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology. Neuro-Oncology. 2010;12(6):520–7. https://doi.org/10.1093/neuonc/nop066.
Jazayeri SB, Rahimi-Movaghar V, Shokraneh F, Saadat S, Ramezani R. Epidemiology of primary CNS tumors in Iran: a systematic review. Asian Pac J Cancer Prev. 2013;14(6):3979–85. https://doi.org/10.7314/APJCP.2013.14.6.3979.
Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011-2015. Neuro-Oncology. 2018;20:iv1–iv86. https://doi.org/10.1093/neuonc/noy131.
Aguirre-Cruz L, Rangel-López E, de la Cruz-Aguilera DL, Rodríguez-Pérez CE, Ruano L, Velásquez-Pérez L, Martínez-Moreno M, Garduño-Espinosa J, Sotelo J. Distribución histórica de neoplasias del sistema nervioso central en el Instituto Nacional de Neurología y Neurocirugía de México. Salud Publica Mex. 2016;58(2):171–8.
Anaya-Delgadillo G, de Juambelz-Cisneros PP, Fernández-Alvarado B, Pazos-Gómez F, Velasco-Torre A, Revuelta-Gutiérrez R. Prevalencia de tumores del sistema nervioso central y su identificación histológica en pacientes operados: 20 años de experiencia. Cir Cir. 2016;84(6):447–53. https://doi.org/10.1016/j.circir.2016.01.004.
Hernández-Hernández A, Reyes-Moreno I, Gutiérrez-Aceves A, Guerrero-Juárez V, Santos-Zambrano J, Averdaño Méndez-Padilla J, Gonález-Aguilar A. Primary tumors of the central nervous system. Clinical experience at a third level center. Revista de Investigacin Clnica. 2018;70(4):8–9. https://doi.org/10.24875/RIC.18002399.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30. https://doi.org/10.3322/caac.21387.
Barnholtz-Sloan JS, Ostrom QT, Cote D. Epidemiology of brain tumors. Neurol Clin. 2018;36(3):395–419. https://doi.org/10.1016/j.ncl.2018.04.001.
Wegman-Ostrosky T, Reynoso-Noverón N, Mejía-Pérez SI, Sánchez-Correa TE, Alvarez-Gómez RM, Vidal-Millán S, Cacho-Díaz B, Sánchez-Corona J, Herrera-Montalvo LA, Corona-Vázquez T. Clinical prognostic factors in adults with astrocytoma: historic cohort. Clin Neurol Neurosurg. 2016;146:116–22. https://doi.org/10.1016/j.clineuro.2016.05.002.
Bleeker FE, Hopman SMJ, Merks JHM, Aalfs CM, Hennekam RCM. Brain tumors and syndromes in children. Neuropediatrics. 2014;45(3):137–61. https://doi.org/10.1055/s-0034-1368116.
Davis F, Il’yasova D, Rankin K, McCarthy B, Bigner DD. Medical diagnostic radiation exposures and risk of gliomas. Radiat Res. 2011;175(6):790–6. https://doi.org/10.1667/RR2186.1.
Lee PN, Thornton AJ, Hamling JS. Epidemiological evidence on environmental tobacco smoke and cancers other than lung or breast. Regul Toxicol Pharmacol. 2016;80:134–63. https://doi.org/10.1016/j.yrtph.2016.06.012.
Gomes J, Al Zayadi A, Guzman A. Occupational and environmental risk factors of adult primary brain cancers: a systematic review. Int J Occup Environ Med. 2011;2(2):82–111.
McElvenny DM, Van Tongeren M, Turner MC, Benke G, Figuerola J, Fleming S, Hours M, Kincl L, Krewski D, McLean D, Parent MÉ, Richardson L, Schlehofer B, Schlaefer K, Sadetzki S, Schüz J, Siemiatycki J, Cardis E. The INTEROCC case-control study: risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents. Occup Environ Med. 2018;75(1):12–22. https://doi.org/10.1136/oemed-2016-104280.
Tykocki T, Eltayeb M. Ten-year survival in glioblastoma: a systematic review. J Clin Neurosci. 2018;54:7–13. https://doi.org/10.1016/j.jocn.2018.05.002.
Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomark Prev. 2014;23(10):1985–96. https://doi.org/10.1158/1055-9965.EPI-14-0275.
Mohar-Betancourt A, Alvarado-Miranda A, Torres-Domínguez JA, Cabrera P, Lara-Medina F, Villarreal-Gómez YS, Reynoso-Noverón N. Factores pronósticos en pacientes con cáncer de mama y metástasis cerebral como primer sitio de recurrencia. Salud Publica Mex. 2018;60(2):141–50. https://doi.org/10.21149/9082.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G. Glioma. Nat Rev Dis Primers. 2015;1:15017. https://doi.org/10.1038/nrdp.2015.17.
Duong LM, McCarthy BJ, McLendon RE, Dolecek TA, Kruchko C, Douglas LL, Ajani UA. Descriptive epidemiology of malignant and nonmalignant primary spinal cord, spinal meninges, and cauda equina tumors, United States, 2004-2007. Cancer. 2012;118(17):4220–7. https://doi.org/10.1002/cncr.27390.
Shonka N, Venur VA, Ahluwalia MS. Targeted treatment of brain metastases. Curr Neurol Neurosci Rep. 2017;17(4):37. https://doi.org/10.1007/s11910-017-0741-2.
Lian W, Wang R, Xing B, Yao Y. Fish intake and the risk of brain tumor: a meta-analysis with systematic review. Nutr J. 2017;16(1):1–8. https://doi.org/10.1186/s12937-016-0223-4.
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Reynoso-Noverón, N., Mohar-Betancourt, A., Ortiz-Rafael, J. (2021). Epidemiology of Brain Tumors. In: Monroy-Sosa, A., Chakravarthi, S.S., de la Garza-Salazar, J.G., Meneses Garcia, A., Kassam, A.B. (eds) Principles of Neuro-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-54879-7_2
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