Skip to main content

Neuropsychological Assessment in Brain Tumor Patients

  • Chapter
  • First Online:
Principles of Neuro-Oncology
  • 2425 Accesses

Abstract

Advances in cancer treatment have improved survival rates, and the number of studies on survivors has thus increased. These studies have been focusing more on aspects such as cognitive decline and quality of life.

Brain tumor patients are definitely not an exception, which has compelled researchers in this field to devise more effective strategies for diagnosis, prognosis, management, and follow-up, particularly in rehabilitation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Noone AM, Howlader N, Krapcho M, et al. SEER cancer statistics review, 1975–2015, based on November 2017 SEER data submission. Bethesda, MD: National Cancer Institute; 2018. Available from https://seer.cancer.gov/csr/1975_2015

    Google Scholar 

  2. White T, Zavarella S, Jarchin L, et al. Combined brain mapping and compact intraoperative MRI for brain tumor resection. Stereotact Funct Neurosurg. 2018;96:172–81. https://doi.org/10.1159/000488991.

    Article  PubMed  Google Scholar 

  3. Hervey-Jumper SL, et al. Awake craniotomy o maximize glioma resection: methods and technical nuances over a 27-year period. J Neurosurg. 2015;123:325–39.

    Article  Google Scholar 

  4. Puhr A, Ruud E, Anderson V, et al. Self-reported executive dysfunction, fatigue, and psychological and emotional symptoms in physically well-functioning long-term survivors of pediatric brain tumor. Dev Neuropsychol. 2018;44:88–103. https://doi.org/10.1080/87565641.2018.1540007.

    Article  PubMed  Google Scholar 

  5. Sage W, Fernández-Méndez R, Crofton A, et al. Defining unmet clinical need across the pathway of brain tumor care: a patient and carer perspective. Cancer Manag Res. 2019;11:2189–202.

    Article  Google Scholar 

  6. Aarsen FK, Paquier PF, Arts WF, et al. Cognitive deficits and predictors 3 years after diagnosis of a pilocytic astrocytoma in childhood. J Clin Oncol. 2009;27(21):3526–32. https://doi.org/10.1200/jco.2008.19.6303.

    Article  PubMed  Google Scholar 

  7. Brinkman TM, Krasin MJ, Liu W, et al. Long-term neurocognitive functioning and social attainment in adult survivors of pediatric CNS tumors: results from the St Jude lifetime cohort study. J Clin Oncol. 2016;34(12):1358–67. https://doi.org/10.1200/JCO.2015.62.2589.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Vingerhoets G. Cognitive effects of seizures. Seizure. 2006;15(4):221–6. https://doi.org/10.1016/j.seizure.2006.02.012.

    Article  PubMed  Google Scholar 

  9. Noll KR, Fardell JE. Commentary: neuropsychological assessment of individuals with brain tumor: comparison of approaches used in the classification of impairment. Front Oncol. 2015;5:56. https://doi.org/10.3389/fonc.2015.00188.

    Article  Google Scholar 

  10. Gilbert MR, Dignam JJ, Armstrong TS, Wefel JS, Blumenthal DT, Vogelbaum MA, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N EnglJMed. 2014;370:699–708. https://doi.org/10.1056/NEJMoa1308573.

    Article  CAS  Google Scholar 

  11. Dwan TM, Ownsworth T, Chambers S, et al. Neuropsychological assessment of individuals with brain tumor: comparison of approaches used in the classification of impairment. Front Oncol. 2015;5:56. https://doi.org/10.3389/fonc.2015.00056.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Durand T, Berzero G, Bompaire F, et al. Episodic memory impairments in primary brain tumor patients. Arch Clin Neuropsychol. 2018;33:1–7.

    Article  Google Scholar 

  13. Bower JE. Cancer-related fatigue—mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11:597–609. https://doi.org/10.1038/nrclinonc.2014.127.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Zeller B, Ruud E, Havard Loge J, et al. Chronic fatigue in adult survivors of childhood cancer: associated symptoms, neuroendocrine markers, and autonomic cardiovascular responses. Psychosomatics. 2014;55(6):621–9. https://doi.org/10.1016/j.psym.2013.12.005.

    Article  PubMed  Google Scholar 

  15. Hocking MC, Paltin I, Lauren F, et al. Acceptability and feasibility in a pilot randomized clinical trial of computerized working memory training and parental problem-solving training with pediatric brain tumor survivors. J Pediatr Psychol. 2019;44:1–10. https://doi.org/10.1093/jpepsy/jsz015.

    Article  Google Scholar 

  16. Loughan AR, Braun SE, Lanoye A. Executive dysfunction in neuro-oncology: behavior rating inventory of executive function in adult primary brain tumor patients. Applied Neuropsychology Adult. 2019;5:1–10. https://doi.org/10.1080/23279095.2018.1553175.

    Article  Google Scholar 

  17. Richard NM, Bernstein LJ, Mason WP, et al. Cognitive rehabilitation for executive dysfunction in brain tumor patients: a pilot randomized controlled trial. J Neuro-Oncol. 2019;142(3):565–75. https://doi.org/10.1007/s11060-019-03130-1.

    Article  Google Scholar 

  18. Mariani M, William M, Collins G. Neuropsychological profiles of breast cancer and brain tumor cohorts in Northeast Ontario, Canada. Support Care Cancer. 2018;26(11):3801–9. https://doi.org/10.1007/s00520-018-4247-5.

    Article  PubMed  Google Scholar 

  19. Wongsripuemtet J, Tyan AE, Carass A, et al. Preoperative mapping of the supplementary motor area in patients with brain tumor using resting-state fMRI with seed-based analysis. AJNR Am J Neuroradiol. 2018;39(8):1493–8. https://doi.org/10.3174/ajnr.A5709.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Russell SM, Kelly PJ. Incidence and clinical evolution of postoperative deficits after volumetric stereotactic resection of glial neoplasms involving the supplementary motor area. Neurosurgery. 2003;52:506–16.

    Article  Google Scholar 

  21. Gatta G, Botta L, Rossi S, et al. Childhood cáncer survival in Europe 1999–2007: results of EUROCARE-5—A population-based study. Lancet Oncol. 2014;15(1):35–47. https://doi.org/10.1016/S1470-2045(13)70548-5.

    Article  PubMed  Google Scholar 

  22. Samann PG, Wehrle R, Hoehn D, et al. Development of the brain’s default mode network from wakefulness to slow wave sleep. Cereb Cortex. 2011;21:2082–93.

    Article  Google Scholar 

  23. Fontaine D, Capelle L, Duffau H. Somatotopy of the supplementary motor area: evidence from correlation of the extent of surgical resection with the clinical patterns of deficit. Neurosurgery. 2002;50:297–303.

    PubMed  Google Scholar 

  24. Duffner PK. Risk factors for cognitive decline in children treated for brain tumors. Eur J Paediatr Neurol. 2010;14(2):106–15. https://doi.org/10.1016/j.ejpn.2009.10.005.

    Article  PubMed  Google Scholar 

  25. Zhao X, Li Y, Tian Q, Zhu B, et al. Repetitive transcranial magnetic stimulation increases serum brain-derived neurotrophic factor and decreases interleukin-1beta and tumor necrosis factor-alpha in elderly patients with refractory depression. J Int Med Res. 2019;47:1848–55. https://doi.org/10.1177/0300060518817417.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Metwali H, Raemaekers M, Kniese K, et al. Reliability of functional magnetic resonance imaging in patients with brain tumors: a critical review and meta-analysis. World Neurosurgery. 2019;125:183–90. https://doi.org/10.1016/j.wneu.2019.01.194.

    Article  PubMed  Google Scholar 

  27. Ailion AS, King TZ, Wang LF, et al. Cerebellar atrophy in adult survivors of childhood cerebellar tumor. J Int Neuropsychol Soc. 2016;22(5):501–11. https://doi.org/10.1017/s1355617716000138.

    Article  PubMed  Google Scholar 

  28. Oda K, Yamaguchi F, Enomoto H, et al. Prediction of recovery from supplementary motor área syndrome after brain tumor surgery: preoperative diffusion tensor tractography analysis and postoperative neurological clinical course. Neurosurg Focus. 2018;44(6):E3.

    Article  Google Scholar 

  29. Schipmann S, Brix T, Varghese J, et al. Adverse events in brain tumor surgery: incidence, type, and impact on current quality metrics. Acta Neurochir. 2019;161:287–306. https://doi.org/10.1007/s00701-018-03790-4.

    Article  PubMed  Google Scholar 

  30. Branco P, Seixas D, Deprez S, et al. Resting-state functional magnetic resonance imaging for language preoperative planning. Front Hum Neurosci. 2016;10:11.

    Article  Google Scholar 

  31. Bizzi A, Blasi V, Falini A, et al. Presurgical functionalMRimaging of language and motor functions: validation with intraoperative electrocortical mapping. Radiology. 2008;248:579–89.

    Article  Google Scholar 

  32. Kahalley LS, Ris MD, Mahajan A, et al. Prospective, longitudinal comparison of neurocognitive change in pediatric brain tumor patients treated with proton radiotherapy versus surgery only. Neuro-Oncology. 2019 Jun 10;21(6):809–18. https://doi.org/10.1093/neuonc/noz041.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Winocur G, Henkelman M, Wojtowicz JM, et al. The effects of chemotherapy on cognitive function in a mouse model: a prospective study. Clin Cancer Res. 2012;18:3112–21.

    Article  CAS  Google Scholar 

  34. Grabow D, Spix C, Blettner M, et al. Strategy for long-term surveillance at the German childhood cancer registry—an update. Klin Padiatr. 2011;223(3):159–64.

    Article  CAS  Google Scholar 

  35. Scholtes C, Baust K, Weinhold L, et al. Health status, health-related quality of life, and socioeconomic outcome in childhood brain tumor survivors: a German cohort study. Neuro-Oncology. 2019;21:1–13. https://doi.org/10.1093/neuonc/noz044/5355656.

    Article  Google Scholar 

  36. Fayers PM, Aaronson NK, Bjordal K, et al. The EORTC QLQ-C30 scoring manual. 3rd ed. Brussels: European Organisation for Research and Treatment of Cancer; 2001.

    Google Scholar 

  37. State & Society—Households & Families—Microcensus-Federal Statistical Office (Destatis). https://www.destatis.de/EN/FactsFigures/SocietyState/Population/HouseholdsFamilies/Methods/Microcensus.html. Accessed 23 May 2018.

  38. Ospina R, Ferrari SLP. A general class of zero-or-one inflated beta regression models. Comput Stat Data Anal. 2012;56(6):1609–23.

    Article  Google Scholar 

  39. Canivez GL. Incremental criterion validity of WAIS-IV factor index scores: relationships with WIAT-II and WIAT-III subtest and composite scores. Psychoîogical Assessment. 2013;25(2):484–95. https://doi.org/10.1037/a0032092.

    Article  Google Scholar 

  40. Ellenberg L, Liu Q, Gioia G, et al. Neurocognitive status in long-term survivors of childhood CNS malignancies: a report from the childhood cancer survivor study. Neuropsychology. 2009;23(6):705–17.

    Article  Google Scholar 

  41. Finocchiaro CY, Petruzzi A, Fedeli G, et al. Hidden reality: sexual sphere in brain tumor patients. Psychol Health Med. 2016;13:48–27. https://doi.org/10.1080/13548506.2016.1210176.

    Article  Google Scholar 

  42. Wolfe KR, Madan-Swain A, Kana RK. Executive dysfunction in pediatric posterior fossa tumor survivors: A systematic literature review of neurocognitive deficits and interventions. Dev Neuropsychol. 2012;37(2):153–75. https://doi.org/10.1080/87565641.2011.632462.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Wolfe KR, Walsh KS, Reynolds NC, et al. Executive functions and social skills in survivors of pediatric brain tumor. Child Neuropsychol. 2013;19(4):370–84. https://doi.org/10.1080/09297049.2012.669470.

    Article  PubMed  Google Scholar 

  44. Palmer SL, Goloubeva O, Reddick WE, et al. Patterns of intelectual development among survivors of pediatric medulloblastoma: a longitudinal analysis. J Clin Oncol. 2001;19(8):2302–8.

    Article  CAS  Google Scholar 

  45. Putcha D, Brickhouse M, Wolk DA, et al. Fractionating the Rey auditory verbal learning test: distinct roles of large scale cortical networks in prodromal Alzheimer's disease. Neuropsychologia. 2019;129:83–92.

    Article  Google Scholar 

  46. Sagberga LM, Iversenc DH, Fyllingen EH, et al. Brain atlas for assessing the impact of tumor location on perioperative quality of life in patients with high-grade glioma: a prospective population based cohort study. NeuroImage. 21:101658. https://doi.org/10.1016/j.nicl.2019.101658.

  47. Winter AL, Conklin HM, Tyc VL, et al. Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia. J Clin Exp Neuropsychol. 2014;36(8):818–30. https://doi.org/10.1080/13803395.2014.943695/000084860.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Merchant TE, Conklin HM, Wu S, et al. Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits. J Clin Oncol. 2009;27(22):3691–7.

    Article  Google Scholar 

  49. Moxon-Emre I, Taylor BE, et al. Impact of craniospinal dose, boost volume, and neurologic complications on intellectual outcome in patients with medulloblastoma. J Clin Oncol. 2014;32(17):1760–8.

    Article  Google Scholar 

  50. Smith-Cohn M, Chen Z, Peereboom D, et al. Maximizing function and quality of life of patients with glioblastoma after surgical resection: a review of current literature. J Cancer Ther. 2016;07(12):857–88. https://doi.org/10.4236/jct.2016.712085.

    Article  Google Scholar 

  51. Huang H-W, Yan L-M, Yang Y-L, et al. Bi-frontal pneumocephalus is an independent risk factor for early postoperative agitation in adult patients admitted to intensive care unit after elective craniotomy for brain tumor: a prospective cohort study. PLoS One. 2018;13(7):e0201064. https://doi.org/10.1371/journal.pone.0201064.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Reimers TS, Mortensen EL, Nysom K, et al. Health-related quality of life in long-term survivors of childhood brain tumors. Pediatr Blood Cancer. 2009;53(6):1086–91. https://doi.org/10.1002/pbc.22122.

    Article  PubMed  Google Scholar 

  53. Hodgson KD, Hutchinson AD, Wilson CJ, et al. A meta-analysis of the effects of chemotherapy on cognition in patients with cancer. Cancer Treat Rev. 2013;39:297–304.

    Article  CAS  Google Scholar 

  54. Bobes J, G-Portilla MP, Bascaran MT, et al. Banco de Instrumentos básicos para la práctica de la psiquiatría clínica. 3rd ed. Barcelona: Ars Medica; 2004.

    Google Scholar 

  55. Ruis C, Wajer IH, Robe P, et al. Anxiety in the preoperative phase of awake brain tumor surgery. Clin Neurol Neurosurg. 157:7–10. https://doi.org/10.1016/j.clineuro.2017.03.018.

  56. USzulc K, Timmons BW, Bouffet E, et al. Repairing the brain with physical exercise: cortical thickness and brain volume increases in long-term pediatric brain tumor survivors in response to a structured exercise intervention. NeuroImage. 2017;18:972–85. https://doi.org/10.1016/j.nicl.2018.02.021.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Rodríguez-Orozco, J. (2021). Neuropsychological Assessment in Brain Tumor Patients. In: Monroy-Sosa, A., Chakravarthi, S.S., de la Garza-Salazar, J.G., Meneses Garcia, A., Kassam, A.B. (eds) Principles of Neuro-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-54879-7_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-54879-7_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-54878-0

  • Online ISBN: 978-3-030-54879-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics