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Use of Physical Approaches for Systemic Drug Delivery

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Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 13))

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Abstract

Physical methods of drug delivery involve application of physical forces to deliver drugs using different approaches. These approaches combine forces (such as magnetic, thermal, ballistic, and electrical forces) with novel formulation techniques, for example, those in targeted drug delivery. The important approaches include iontophoresis, low-frequency ultrasound, electrophoresis, magnetic drug delivery, and the use of microneedles. Physical methods have been used for the treatment of various tumors, targeted delivery of drugs and genes, magnetic resonance imaging, cell purification, and hyperthermia. In this chapter, we will provide an overview of the strategies employed in physical methods of drug delivery. The working principles underlying ultrasound-, photo-, magnetic-, and electrical-based delivery methods, as well as the possible use of microneedles to control drug release, will be presented. Clinical applications relevant to these methods will also be discussed.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Marshall B. Ketchum University, Fullerton, CA, 92831, USA

    Rajesh Vadlapatla, Zhijun Wang & Priyank Kumar

  2. School of Pharmacy, Lake Earie College of Osteopathic Medicine, Bradenton, FL, 34211, USA

    Nina Pavuluri

Authors
  1. Rajesh Vadlapatla
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  2. Zhijun Wang
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  3. Priyank Kumar
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  4. Nina Pavuluri
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Corresponding author

Correspondence to Rajesh Vadlapatla .

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Editors and Affiliations

  1. School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China

    Wing-Fu Lai

Glossary

Active targeting

Selective transport of a carrier to specific cells/tissues by modifying the carrier with a chemical group that can be recognized specifically by those target cells/tissues.

Dielectrophoresis

Motion of a neutral particle caused by polarization effects in a non-uniform electric field.

Erythema

Abnormal redness of the skin or the mucous membrane caused by capillary congestion.

Iontophoresis

A method in which the charged drug is delivered through the biological membranes under the influence of very mild electric current.

Magnetic liposomes

Vesicular, colloidal particles prepared by entrapment of ferro fluid within the core of liposomes.

Magnetic microspheres

Supramolecular magnetic hollow spherical particles in the micrometer size range. They are comprised of different materials such as proteins or synthetic polymers.

Microneedles

Miniature needles fabricated from lithographic techniques for transdermal drug delivery.

P-glycoprotein

A 170-kDa plasma membrane protein which is thought to be responsible for the occurence of multidrug resistance in mammalian cells.

Proto-oncogenes

Genes that show the potential to be changed into active oncogenes.

Reverse electroporation

A technique that involves temporary permeabilization of the cell membrane under the influence of a short electric impulse. This technique can be utilized to deliver a wide range of therapeutic agents including, dyes, tracers, antibodies, and oligoneucleotides.

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Vadlapatla, R., Wang, Z., Kumar, P., Pavuluri, N. (2020). Use of Physical Approaches for Systemic Drug Delivery. In: Lai, WF. (eds) Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Healthy Ageing and Longevity, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-54490-4_11

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