Abstract
Valvular heart disease occurs when one or multiple valves of the heart are damaged or diseased. About 2.5% of the US population has valvular heart disease, but it is more common in older adults. About 13% of people born before 1943 have valvular heart disease [1]. In 2017, there were 3046 deaths due to rheumatic valvular heart disease and 24,811 deaths due to non-rheumatic valvular heart disease in the USA. Nearly 25,000 deaths in the USA each year are due to heart valve disease from causes other than rheumatic disease. Valvular heart disease deaths are more commonly due to aortic valve disease [2]. There are several causes of valvular heart disease, including congenital conditions, infections, degenerative conditions (wearing out with age), and conditions linked to other types of heart disease [1]. Valvular heart disease is recognized by finding a heart murmur. Here, even more than elsewhere in cardiology, the physical findings are all important to making a diagnosis and assessing severity. Often, they trump the results of special testing. Murmurs may first be detected in a symptomless patient, perhaps a young would-be athlete at a high school physical examination, or they may be the clue in someone with dyspnea and fluid retention that valvular disease is the reason for their cardiac failure [3]. The family physician is in a particularly challenging position because we will be addressing these potential concerns at every stage of life and often may be dealing with determining the significance of a new heart sound as an incidental finding. Valvular disease may lead to decreased functional status, permanent structural changes, and increased mortality. Timely diagnosis and appropriate testing and consultation are the goals of the family physician, in order to prevent the negative sequelae of inappropriately addressing valvular disease. Learning maneuvers and understanding the sounds present within the heart facilitate appropriate diagnosis [4].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Otto CM, Bonow RO. Valvular heart disease: a companion to Braunwald’s heart disease. 4th ed. Philadelphia: Elsevier Saunders; 2014.
Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999–2017 on CDC WONDER Online Database, released December, 2018. Data are from the Multiple Cause of Death Files, 1999–2017, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed at http://wonder.cdc.gov/ucd-icd10.html on Oct 24, 2019.
Ashar BH, Miller RG, Sisson SD. The Johns Hopkins internal medicine board review. 4th ed.
Paulman P, Taylor RB, Paulman AA, Nasir LS. Family medicine, principles and practice. 7th ed; 2017.
Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin 3rd JP, Guyton RA, et al. AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(23):2440–922020. ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2020. Epublished https://doi.org/10.1016/j.jacc.2020.11.018.
Ashley EA, Niebauer J. Cardiology explained. London: Remedica; 2004.
The Manual Merck of diagnosis and therapy. 18th ed; 2006.
Maganti K, Rigolin VH, Sarano ME, Bonow RO. Valvular heart disease: diagnosis and management. Mayo Clin Proc. 2010;85(5):483–500.
2020 ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2020. Epublished https://doi.org/10.1016/j.jacc.2020.11.018.
Maganti K, Rigolin VH, Sarano ME, Bonow RO. Valvular heart disease: diagnosis and management. Mayo Clinic Proc. 2010; https://doi.org/10.4065/mcp.2009.0706.
Bonow RO, Carabello BA, Chatterjee K, et al. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease. J Am Coll Cardiol. 2006;48:1–148.
Lung B, Gohlke-Barwolf C, Tornos P, et al. For the working group on valvular heart disease: recommendations on the management of the asymptomatic patient with valvular heart disease. Eur Heart. 2002;J23:1252–66.
Otto CM. Evaluation and management of chronic mitral regurgitation. N Engl J Med. 2001;345:740–6. Otto CM: Valvular aortic stenosis: disease severity and timing of intervention, J Am Coll Cardiol 47:2141–51, 2006.
Eveborn GW, Schirmer H, Heggelund G, et al. The evolving epidemiology of valvular aortic stenosis the Tromsø study. Heart. 2013;99:396.
Otto CM, Burwash IG, Legget ME, et al. Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation. 1997;95:2262.
Rosenhek R, Zilberszac R, Schemper M, et al. Natural history of very severe aortic stenosis. Circulation. 2010;121:151.
Rosenhek R, Binder T, Porenta G, et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med. 2000;343:611.
Pohle K, Mäffert R, Ropers D, et al. Progression of aortic valve calcification: association with coronary atherosclerosis and cardiovascular risk factors. Circulation. 2001;104:1927.
Gosavi S, Channa R, Mukherjee D. Systemic hypertension in patients with aortic stenosis: clinical implications and principles of pharmacological therapy. Cardiovasc Hematol Agents Med Chem. 2015;13:50.
Semsarian C, Ingles J, Maron MS, Maron BJ. New perspectives on the prevalence of hypertrophic cardiomyopathy. J Am Coll Cardiol. 2015;65:1249.
Richard P, Charron P, Carrier L, et al. Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. Circulation. 2003;107:2227.
Ommen SR, Mital S, Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P. 2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 76(25):e159–240.
Maron BJ. Clinical course and management of hypertrophic cardiomyopathy. N Engl J Med. 2018;379:655.
Silbiger JJ. Abnormalities of the mitral apparatus in hypertrophic cardiomyopathy: echocardiographic, pathophysiologic, and surgical insights. J Am Soc Echocardiogr. 2016;29:622.
Zühlke L, Engel ME, Karthikeyan G, et al. Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the global rheumatic heart disease registry (the REMEDY study). Eur Heart J. 2015;36:1115.
Chandrashekhar Y, Westaby S, Narula J. Mitral stenosis. Lancet. 2009;374:1271.
Marcus RH, Sareli P, Pocock WA, Barlow JB. The spectrum of severe rheumatic mitral valve disease in a developing country. Correlations among clinical presentation, surgical pathologic findings, and hemodynamic sequelae. Ann Intern Med. 1994;120:177.
Topilsky Y, Michelena H, Bichara V, et al. Mitral valve prolapse with mid-late systolic mitral regurgitation: pitfalls of evaluation and clinical outcome compared with holosystolic regurgitation. Circulation. 2012;125:1643.
Baumgartner H, Falk V, Bax JJ, et al. 2017 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J. 2017;38:2739.
Enriquez-Sarano M, Akins CW, Vahanian A. Mitral regurgitation. Lancet. 2009;373:1382.
Gaasch WH, Meyer TE. Left ventricular response to mitral regurgitation: implications for management. Circulation. 2008;118:2298.
Maron BJ, Thompson PD, Ackerman MJ, et al. Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 update. Circulation. 2007;15:1643–55.
Sharma S, Estes NA 3rd, Vetter VL, Corrado D. Clinical decisions. Cardiac screening before participation in sports. N Engl J Med. 2013;369:2049.
American Academy of Pediatrics, American Academy of Family Physicians, Am College of Sports Med. Preparticipation Physical Evaluation, 5th ed. American Academy of Pediatrics, Elk Grove Village, IL 2019.
Harmon KG, Asif IM, Maleszewski JJ, et al. Incidence, cause, and comparative frequency of sudden cardiac death in National Collegiate Athletic Association athletes: a decade in review. Circulation. 2015;132:10–9.
Corrado D, Pelliccia A, Heidlbuchel H, et al. Recommendations for interpresteations of 12lead electrocardiogram in the athlete. Eur Heart J. 2010;31:243.
Holst AG, Winkel BG, Theilade J, et al. Incidence and etiology of sports-related sudden cardiac death in Denmark – implications for preparticipation screening. Heart Rhythm. 2010;7:1365–71.
Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, O’Gara PT, Rigolin VH, Sundt TM 3rd, Thompson A, Toly C. ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines. Circulation. 2021;2020:143. https://doi.org/10.1161/CIR.0000000000000923.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this entry
Cite this entry
Malary Carter, S., Bocaille, W., Reyes-Alonso, S. (2022). Valvular Heart Disease. In: Paulman, P.M., Taylor, R.B., Paulman, A.A., Nasir, L.S. (eds) Family Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-54441-6_193
Download citation
DOI: https://doi.org/10.1007/978-3-030-54441-6_193
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-54440-9
Online ISBN: 978-3-030-54441-6
eBook Packages: MedicineReference Module Medicine