Abstract
Midodrine is commonly used to assist PoTS symptoms. It is an alpha-adrenergic vasoconstrictor, increasing cardiac filling thus improving pre-load. It is short-acting and need to be taken several times a day for efficacy. It has few major side-effects but care needs to be taken to ensure that it does not produce hypertension, particularly when supine. It has few major drug-drug interactions. There are a number of short-term studies highlighting benefit but there are no long-term studies of efficacy.
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Gall, N. (2021). Midodrine. In: Gall, N., Kavi, L., Lobo, M.D. (eds) Postural Tachycardia Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-030-54165-1_28
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DOI: https://doi.org/10.1007/978-3-030-54165-1_28
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