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Chronic Lymphocytic Leukemia

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Blood and Marrow Transplant Handbook

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Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Introduction of novel targeted therapies resulted in a significant paradigm shift in the treatment of CLL in recent years, leading to improved patient outcomes and arguably limited the role of cellular therapies. However, remaining unmet needs, in particular patients with high-risk disease (those with TP53 aberrations or complex karyotype) and those progressing on novel agents, justify continued interest in cellular therapies in this disease, including allogeneic cell transplantation (HCT) and chimeric antigen receptor T (CAR-T) cells. Here, we summarize the current state of affairs in this field.

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Acknowledgments

AVD is a Leukemia and Lymphoma Society Scholar in Clinical Research (#2319-19).

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Authors and Affiliations

  1. Department of Hematology, City of Hope National Medical Center, Duarte, CA, USA

    Alexey V. Danilov

  2. Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA

    Veronika Bachanova

Authors
  1. Alexey V. Danilov
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  2. Veronika Bachanova
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Correspondence to Alexey V. Danilov .

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Editors and Affiliations

  1. Center for Hematologic Malignancies Adult Blood and Marrow Transplant & Cell Therapy Program, Knight Cancer Institute Oregon Health & Science University, Portland, OR, USA

    Richard T. Maziarz

  2. Center for Hematologic Malignancies Adult Blood and Marrow Transplant & Cell Therapy Program, Knight Cancer Institute Oregon Health & Science University, Portland, OR, USA

    Susan Schubach Slater

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Danilov, A.V., Bachanova, V. (2021). Chronic Lymphocytic Leukemia. In: Maziarz, R.T., Slater, S.S. (eds) Blood and Marrow Transplant Handbook. Springer, Cham. https://doi.org/10.1007/978-3-030-53626-8_22

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  • DOI: https://doi.org/10.1007/978-3-030-53626-8_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53625-1

  • Online ISBN: 978-3-030-53626-8

  • eBook Packages: MedicineMedicine (R0)

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