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Disseminated Intravascular Coagulation

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Pediatric Critical Care

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Abstract

This chapter will focus on disseminated intravascular coagulation (DIC), a condition associated with substantial morbidity and mortality in adults and children alike. This is an intense area of research and the pathophysiology driving this condition is being understood at an ever increasing level of sophistication and detail. The underlying conditions predisposing to DIC will be described including sepsis, trauma, vascular anomalies and oncologic diseases. In addition, the clinical aspects of DIC will be considered and the differential diagnoses delineated. Knowing these differential diagnoses is vital to the pediatric intensive care practitioner as a number of these conditions have specific therapies that may improve outcomes if implemented in a timely manner. Further, the available scoring systems used in identifying overt DIC and sepsis-induced coagulopathy will be provided. Treatment options based on knowledge of DIC pathophysiology will be reviewed and the results of corresponding clinical trials assessing their impact will be described.

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Author information

Authors and Affiliations

  1. Pediatric Palliative and Critical Care Medicine, Department of Pediatrics, Geisinger Medical Center, Janet Weis Children’s Hospital, Danville, PA, USA

    Robert F. Tamburro

  2. Division of Haematology/Oncology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada

    Ahmad Al-Huniti & Leonardo R. Brandão

  3. Department of Critical Care Medicine, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada

    Mariella Vargas-Gutierrez & Jorge Gonzalez Ulloa

Authors
  1. Robert F. Tamburro
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  2. Ahmad Al-Huniti
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  3. Mariella Vargas-Gutierrez
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  4. Jorge Gonzalez Ulloa
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  5. Leonardo R. Brandão
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Corresponding author

Correspondence to Leonardo R. Brandão .

Editor information

Editors and Affiliations

  1. Penn State Hershey Children’s Hospital, Pediatric Critical Care Medicine, Hershey, PA, USA

    Steven E. Lucking

  2. Division of Pediatric Critical Care, Department of Pediatrics, Janet Weis Children’s Hospital, Geisinger Medical Center, Danville, PA, USA

    Frank A. Maffei

  3. Department of Pediatrics/Divisions of Pediatric Critical and Palliative Care Medicine, Janet Weis Children’s Hospital at Geisinger, Geisinger Commonwealth School of Medicine, Danville, PA, USA

    Robert F. Tamburro

  4. Department of Pediatrics, Eastern Virginia Medical School, Children’s Hospital of The King’s Daughters, Norfolk, VA, USA

    Arno Zaritsky

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Tamburro, R.F., Al-Huniti, A., Vargas-Gutierrez, M., Ulloa, J.G., Brandão, L.R. (2021). Disseminated Intravascular Coagulation. In: Lucking, S.E., Maffei, F.A., Tamburro, R.F., Zaritsky, A. (eds) Pediatric Critical Care . Springer, Cham. https://doi.org/10.1007/978-3-030-53363-2_38

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  • DOI: https://doi.org/10.1007/978-3-030-53363-2_38

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53362-5

  • Online ISBN: 978-3-030-53363-2

  • eBook Packages: MedicineMedicine (R0)

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