Abstract
Regardless of chosen definitions, health, as well as disease, are in their essence only labels describing two enormous groups of phenotypes. Thus, to study either health or disease, we need to understand the factors affecting the development of specific phenotypes. The current paradigm used to explain the development of phenotypes oversimplifies the entire process by omitting the key factor of time. The novel concept of the dynamic pathosome aims to provide a much more detailed picture than the current paradigm. It provides a novel theoretical framework as well as practical applications, but most importantly can change how we perceive health and disease. This chapter reviews the concept of the dynamic pathosome and the benefits it could offer to biomedicine.
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Acknowledgements
The project was supported by the CETOCOEN PLUS (CZ.02.1.01/0.0/0.0/15_003/0000469) project of the Ministry of Education, Youth and Sports of the Czech Republic. The project was also supported by the RECETOX Research Infrastructure (LM2015051 and CZ.02.1.01/0.0/0.0/16_013/0001761). Furthermore, Peter Lenart received support from the Brno Ph.D. Talent competition.
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Lenart, P., Scheringer, M., Bienertová-Vašků, J. (2020). The Dynamic Pathosome: A Surrogate for Health and Disease. In: Sholl, J., Rattan, S.I. (eds) Explaining Health Across the Sciences. Healthy Ageing and Longevity, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-030-52663-4_16
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