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Physiology of Progesterone

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Progestogens in Obstetrics and Gynecology

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Abstract

The major target organ of progesterone is the reproductive system. Progesterone, in association with estrogen, is involved in the development and sexual maturation of the reproductive organs and orchestrates the menstrual cycle. Progesterone takes part in all the processes from the preparation of the uterine decidua, myometrium and cervix during the menstrual cycle through blastocyst implantation and is the key hormone in pregnancy maintenance, sustaining of myometrial quiescence, cervical competence and modulation of the maternal immune system during pregnancy. Accumulating evidence suggests that, in humans, progesterone withdrawal during parturition is probably functional and involves a shift in the balance between progesterone and cortisol, as well as changes in the genomic and non-genomic effects of progesterone at the cellular level. This chapter describes the specific effects of progesterone on the uterus and the cervix during the normal menstrual cycle, in the maintenance of normal pregnancy, and during parturition. Progesterone also has numerous systemic effects and influences other organs outside the female reproductive tract.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel

    Edi Vaisbuch

  2. Department of Obstetrics and Gynecology, Soroka Medical Center, Beer-Sheva, Israel

    Offer Erez

  3. Perinatology Research Branch, NICHD, Bethesda, MI, USA

    Roberto Romero

  4. Perinatology Research Branch, NIH, Maryland, MI, USA

    Roberto Romero

  5. Perinatology Research Branch, DHHS, Detroit, MI, USA

    Roberto Romero

  6. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA

    Roberto Romero

  7. Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA

    Roberto Romero

  8. Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA

    Roberto Romero

  9. Detroit Medical Center, Detroit, MI, USA

    Roberto Romero

  10. Department of Obstetrics and Gynecology, Florida International University, Miami, FL, USA

    Roberto Romero

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  1. Edi Vaisbuch
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  2. Offer Erez
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  3. Roberto Romero
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Editors and Affiliations

  1. Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Howard J.A. Carp

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Vaisbuch, E., Erez, O., Romero, R. (2021). Physiology of Progesterone. In: Carp, H.J. (eds) Progestogens in Obstetrics and Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-030-52508-8_1

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