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Genetics of Autoimmune Liver Diseases

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Liver Immunology

Abstract

Autoimmune liver diseases (AILDs) have an important genetic background. This is supported by different lines of evidence, that is, clustering in families, high concordance rates in monozygotic twins, increased risk of the disease in siblings compared to general population, and association with other autoimmune conditions. In this chapter, we summarize current knowledge regarding each of the three most common AILDs (autoimmune hepatitis, AIH; primary biliary cholangitis, PBC; and primary sclerosing cholangitis, PSC); we then propose a series of possible future lines of investigation to explore the amount of heritability, which is still to be determined.

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Authors and Affiliations

  1. Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

    Alessio Gerussi, Marco Carbone & Pietro Invernizzi

  2. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy

    Rosanna Asselta

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  1. Alessio Gerussi
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  2. Marco Carbone
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  4. Pietro Invernizzi
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Correspondence to Pietro Invernizzi .

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  1. Division of Rheumatology, Allergy and Clinical Immunology, The University of California School of Medicine, Davis, CA, USA

    M. Eric Gershwin

  2. Departments of Medicine and Surgery, Baylor College of Medicine, Houston, TX, USA

    John M. Vierling

  3. Department of Medicine, Teikyo University School of Medicine, Itabashi, Tokyo, Japan

    Atsushi Tanaka

  4. President, Hannover Medical School, Hannover, Germany

    Michael P. Manns

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Gerussi, A., Carbone, M., Asselta, R., Invernizzi, P. (2020). Genetics of Autoimmune Liver Diseases. In: Gershwin, M.E., M. Vierling, J., Tanaka, A., P. Manns, M. (eds) Liver Immunology . Springer, Cham. https://doi.org/10.1007/978-3-030-51709-0_5

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