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Microbial Metabolomics: From Methods to Translational Applications

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Cancer Metabolomics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1280))

Abstract

Most microbe-associated infectious diseases severely affect human health. However, clinical diagnosis of pathogenic diseases remains challenging due to the lack of specific and highly reliable methods. To better understand the diagnosis, pathogenesis, and treatment of these diseases, systems biology-driven metabolomics goes beyond the annotated phenotype and better targets the functions than conventional approaches. As a novel strategy for analysis of metabolomes in microbes, microbial metabolomics has been recently used to study many diseases, such as obesity, urinary tract infection (UTI), and hepatitis C. In this chapter, we attempt to introduce various microbial metabolomics methods to better interpret the microbial metabolism underlying a diversity of infectious diseases and inspire scientists to pay more attention to microbial metabolomics, enabling broadly and efficiently its translational applications to infectious diseases, from molecular diagnosis to therapeutic discovery.

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Acknowledgments

This work was supported by the National Key R&D Program of China (No. 2017YFC1308600 and 2017YFC1308605), the National Natural Science Foundation of China Grants (No. 81274175 and 31670031), the Startup Funding for Specialized Professorship Provided by Shanghai Jiao Tong University (No. WF220441502), and the Fundamental Research Funds for the Central Universities (grant no. 106112015CDJZR468808).

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Authors and Affiliations

  1. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China

    Rui Guo, Xialin Luo, Xu Xin & Haitao Lu

  2. National Chinmedomics Research Center, Sino-America Chinmedomics Technology Collaboration Center, National TCM Key Laboratory of Serum Pharmacochemistry, Harbin, China

    Xu Xin & Xijun Wang

  3. School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia

    Lian Liu

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  1. Rui Guo
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Correspondence to Haitao Lu .

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  1. University of California, Los Angeles, Los Angeles, CA, USA

    Shen Hu

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Guo, R., Luo, X., Xin, X., Liu, L., Wang, X., Lu, H. (2021). Microbial Metabolomics: From Methods to Translational Applications. In: Hu, S. (eds) Cancer Metabolomics. Advances in Experimental Medicine and Biology, vol 1280. Springer, Cham. https://doi.org/10.1007/978-3-030-51652-9_7

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