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Capillary Electrophoresis-Mass Spectrometry for Cancer Metabolomics

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Cancer Metabolomics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1280))

Abstract

This chapter presents the fundamentals, instrumentation, methodology, and applications of capillary electrophoresis-mass spectrometry (CE-MS) for cancer metabolomics. CE offers fast and high-resolution separation of charged analytes from a very small amount of sample. When coupled to MS, it represents a powerful analytical technique enabling identification and quantification of metabolites in biological samples. Several issues need to be addressed when combining CE with MS, especially the interface between CE and MS and the selection of a proper separation methodology, sample pretreatment, and capillary coatings. We will discuss these aspects of CE-MS and detail representative applications for cancer metabolomic analysis.

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Authors and Affiliations

  1. School of Public Health and Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, China

    Xiangdong Xu

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  1. Xiangdong Xu
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Correspondence to Xiangdong Xu .

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Editors and Affiliations

  1. University of California, Los Angeles, Los Angeles, CA, USA

    Shen Hu

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Xu, X. (2021). Capillary Electrophoresis-Mass Spectrometry for Cancer Metabolomics. In: Hu, S. (eds) Cancer Metabolomics. Advances in Experimental Medicine and Biology, vol 1280. Springer, Cham. https://doi.org/10.1007/978-3-030-51652-9_13

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