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Asthma and Chronic Rhinosinusitis: Surgical Management and Outcomes

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Abstract

Appropriate medical therapy is the first-line management for chronic rhinosinusitis (CRS), but patients commonly fail medical therapy and become candidates for endoscopic sinus surgery (ESS) and, potentially, extended ESS. ESS with postoperative therapies such as high-volume corticosteroid irrigation has proven to be efficacious in decreasing CRS symptoms and preventing recurrence of disease. ESS is superior to continued medical therapy in the management of refractory CRS, reduces asthma symptoms and dependence on asthma medications, and facilitates aspirin desensitization for patients with aspirin-exacerbated respiratory disease (AERD). ESS is especially beneficial when comorbid depression and the total economic burden of disease are considered.

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References

  1. Bresciani M, et al. Rhinosinusitis in severe asthma. J Allergy Clin Immunol. 2001;107(1):73–80.

    CAS  PubMed  Google Scholar 

  2. Liou A, et al. Causative and contributive factors to asthma severity and patterns of medication use in patients seeking specialized asthma care. Chest. 2003;124(5):1781–8.

    PubMed  Google Scholar 

  3. Palmer JN, et al. A cross-sectional, population-based survey of U.S. adults with symptoms of chronic rhinosinusitis. Allergy Asthma Proc. 2019;40(1):48–56.

    PubMed  Google Scholar 

  4. Ek A, et al. Chronic rhinosinusitis in asthma is a negative predictor of quality of life: results from the Swedish GA(2)LEN survey. Allergy. 2013;68(10):1314–21.

    CAS  PubMed  Google Scholar 

  5. Hamilos DL. Chronic rhinosinusitis: epidemiology and medical management. J Allergy Clin Immunol. 2011;128(4):693–707; quiz 708-9

    PubMed  Google Scholar 

  6. Rajan JP, et al. Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature. J Allergy Clin Immunol. 2015;135(3):676–81.. e1

    CAS  PubMed  Google Scholar 

  7. Deal RT, Kountakis SE. Significance of nasal polyps in chronic rhinosinusitis: symptoms and surgical outcomes. Laryngoscope. 2004;114(11):1932–5.

    PubMed  Google Scholar 

  8. Dufour X, et al. Diffuse nasal polyposis and endonasal endoscopic surgery: long-term results, a 65-case study. Laryngoscope. 2004;114(11):1982–7.

    PubMed  Google Scholar 

  9. Rudmik L, et al. Defining appropriateness criteria for endoscopic sinus surgery during management of uncomplicated adult chronic rhinosinusitis: a RAND/UCLA appropriateness study. Rhinology. 2016;54(2):117–28.

    PubMed  Google Scholar 

  10. Marambaia PP, et al. Use of the long-term quality of life assessment in the decision to indicate surgery in patients with chronic rhinosinusitis. Braz J Otorhinolaryngol. 2019;85(4):416–21.

    PubMed  Google Scholar 

  11. Schlosser RJ, et al. Asthma quality of life and control after sinus surgery in patients with chronic rhinosinusitis. Allergy. 2017;72(3):483–91.

    CAS  PubMed  Google Scholar 

  12. Chen FH, et al. Long-term results of endoscopic sinus surgery-oriented treatment for chronic rhinosinusitis with asthma. Laryngoscope. 2014;124(1):24–8.

    PubMed  Google Scholar 

  13. Hopkins C, Andrews P, Holy CE. Does time to endoscopic sinus surgery impact outcomes in chronic rhinosinusitis? Retrospective analysis using the UK clinical practice research data. Rhinology. 2015;53(1):18–24.

    CAS  PubMed  Google Scholar 

  14. Hopkins C, Rimmer J, Lund VJ. Does time to endoscopic sinus surgery impact outcomes in chronic rhinosinusitis? Prospective findings from the national comparative audit of surgery for nasal polyposis and chronic rhinosinusitis. Rhinology. 2015;53(1):10–7.

    CAS  PubMed  Google Scholar 

  15. Soler ZM, et al. Cluster analysis and prediction of treatment outcomes for chronic rhinosinusitis. J Allergy Clin Immunol. 2016;137(4):1054–62.

    PubMed  PubMed Central  Google Scholar 

  16. Hopkins C, Rudmik L, Lund VJ. The predictive value of the preoperative sinonasal outcome test-22 score in patients undergoing endoscopic sinus surgery for chronic rhinosinusitis. Laryngoscope. 2015;125(8):1779–84.

    PubMed  Google Scholar 

  17. Smith TL, et al. Medical therapy vs surgery for chronic rhinosinusitis: a prospective, multi-institutional study. Int Forum Allergy Rhinol. 2011;1(4):235–41.

    PubMed  Google Scholar 

  18. Smith TL, et al. Medical therapy vs surgery for chronic rhinosinusitis: a prospective, multi-institutional study with 1-year follow-up. Int Forum Allergy Rhinol. 2013;3(1):4–9.

    PubMed  Google Scholar 

  19. McFadden EA, et al. Surgery for sinusitis and aspirin triad. Laryngoscope. 1990;100(10 Pt 1):1043–6.

    CAS  PubMed  Google Scholar 

  20. Batra PS, et al. Outcome analysis of endoscopic sinus surgery in patients with nasal polyps and asthma. Laryngoscope. 2003;113(10):1703–6.

    PubMed  Google Scholar 

  21. Shah SJ, et al. Endoscopic sinus surgery improves aspirin treatment response in aspirin-exacerbated respiratory disease patients. Int Forum Allergy Rhinol. 2019;9(12):1401–8.

    PubMed  Google Scholar 

  22. Wofford MR, et al. A computational study of functional endoscopic sinus surgery and maxillary sinus drug delivery. Rhinology. 2015;53(1):41–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Kumar H, Jain R. Review: the role of computational simulation in understanding the postoperative sinonasal environment. Clin Biomech (Bristol, Avon). 2019;66:2–10.

    Google Scholar 

  24. Grobler A, et al. Pre- and postoperative sinus penetration of nasal irrigation. Laryngoscope. 2008;118(11):2078–81.

    PubMed  Google Scholar 

  25. Ragab SM, Lund VJ, Scadding G. Evaluation of the medical and surgical treatment of chronic rhinosinusitis: a prospective, randomised, controlled trial. Laryngoscope. 2004;114(5):923–30.

    PubMed  Google Scholar 

  26. Orlandi RR, et al. International consensus statement on allergy and rhinology: rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(Suppl 1):S22–209.

    PubMed  Google Scholar 

  27. Kohanski MA, Toskala E, Kennedy DW. Evolution in the surgical management of chronic rhinosinusitis: current indications and pitfalls. J Allergy Clin Immunol. 2018;141(5):1561–9.

    PubMed  Google Scholar 

  28. Awad OG, et al. Sinonasal outcomes after endoscopic sinus surgery in asthmatic patients with nasal polyps: a difference between aspirin-tolerant and aspirin-induced asthma? Laryngoscope. 2008;118(7):1282–6.

    PubMed  Google Scholar 

  29. Adappa ND, et al. Outcomes after complete endoscopic sinus surgery and aspirin desensitization in aspirin-exacerbated respiratory disease. Int Forum Allergy Rhinol. 2018;8(1):49–53.

    PubMed  Google Scholar 

  30. Jerschow E, et al. Sinus surgery is associated with a decrease in aspirin-induced reaction severity in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2019;7(5):1580–8.

    PubMed  Google Scholar 

  31. Philpott CM, et al. Endoscopic frontal sinusotomy-preventing recurrence or a route to revision? Laryngoscope. 2010;120(8):1682–6.

    PubMed  Google Scholar 

  32. Kerrebijn JD, et al. If functional sinus surgery fails: a radical approach to sinus surgery. Otolaryngol Head Neck Surg. 1996;114(6):745–7.

    CAS  PubMed  Google Scholar 

  33. Bassiouni A, Naidoo Y, Wormald PJ. When FESS fails: the inflammatory load hypothesis in refractory chronic rhinosinusitis. Laryngoscope. 2012;122(2):460–6.

    PubMed  Google Scholar 

  34. Li KL, Lee AY, Abuzeid WM. Aspirin exacerbated respiratory disease: epidemiology, pathophysiology, and management. Med Sci (Basel). 2019;7(3):45.

    Google Scholar 

  35. Mendelsohn D, et al. Revision rates after endoscopic sinus surgery: a recurrence analysis. Ann Otol Rhinol Laryngol. 2011;120(3):162–6.

    PubMed  Google Scholar 

  36. Adelman J, et al. The role of surgery in management of Samter’s triad: a systematic review. Otolaryngol Head Neck Surg. 2016;155(2):220–37.

    PubMed  Google Scholar 

  37. Szczeklik A, Nizankowska E. Clinical features and diagnosis of aspirin induced asthma. Thorax. 2000;55(Suppl 2):S42–4.

    PubMed  PubMed Central  Google Scholar 

  38. Young J, et al. Long-term outcome analysis of endoscopic sinus surgery for chronic sinusitis. Am J Rhinol. 2007;21(6):743–7.

    PubMed  Google Scholar 

  39. Amar YG, Frenkiel S, Sobol SE. Outcome analysis of endoscopic sinus surgery for chronic sinusitis in patients having Samter’s triad. J Otolaryngol. 2000;29(1):7–12.

    CAS  PubMed  Google Scholar 

  40. Buras M, Simoncini A, Gungor A. Auto-obliteration of maxillary sinuses through osteoneogenesis in children with cystic fibrosis: a possible new way to reduce morbidity. Am J Otolaryngol. 2018;39(6):737–40.

    PubMed  Google Scholar 

  41. Friedman WH, Katsantonis GP. Transantral revision of recurrent maxillary and ethmoidal disease following functional intranasal surgery. Otolaryngol Head Neck Surg. 1992;106(4):367–71.

    CAS  PubMed  Google Scholar 

  42. Cho DY, Hwang PH. Results of endoscopic maxillary mega-antrostomy in recalcitrant maxillary sinusitis. Am J Rhinol. 2008;22(6):658–62.

    PubMed  Google Scholar 

  43. Costa ML, et al. Long-term outcomes of endoscopic maxillary mega-antrostomy for refractory chronic maxillary sinusitis. Int Forum Allergy Rhinol. 2015;5(1):60–5.

    PubMed  Google Scholar 

  44. Jankowski R, et al. Updating nasalisation: from concept to technique and results. Eur Ann Otorhinolaryngol Head Neck Dis. 2018;135(5):327–34.

    CAS  PubMed  Google Scholar 

  45. Jankowski R, et al. Comparison of radical (nasalisation) and functional ethmoidectomy in patients with severe sinonasal polyposis. A retrospective study. Rev Laryngol Otol Rhinol (Bord). 2006;127(3):131–40.

    CAS  Google Scholar 

  46. Nguyen DT, Nguyen-Thi PL, Jankowski R. How does measured olfactory function correlate with self-ratings of the sense of smell in patients with nasal polyposis? Laryngoscope. 2012;122(5):947–52.

    PubMed  Google Scholar 

  47. Leight WD, Leopold DA. Sphenoid “drill-out” for chronic sphenoid rhinosinusitis. Int Forum Allergy Rhinol. 2011;1(1):64–9.

    PubMed  Google Scholar 

  48. Soler ZM, Sindwani R, Metson R. Endoscopic sphenoid nasalization for the treatment of advanced sphenoid disease. Otolaryngol Head Neck Surg. 2010;143(3):456–8.

    PubMed  Google Scholar 

  49. Minni A, et al. Use of balloon catheter dilation and steroid-eluting stent in light and severe rhinosinusitis of frontal sinus: a multicenter retrospective randomized study. Eur Rev Med Pharmacol Sci. 2018;22(21):7482–91.

    CAS  PubMed  Google Scholar 

  50. Naidoo Y, et al. Risk factors and outcomes for primary, revision, and modified Lothrop (Draf III) frontal sinus surgery. Int Forum Allergy Rhinol. 2013;3(5):412–7.

    PubMed  Google Scholar 

  51. Chandra RK, et al. Factors associated with failure of frontal sinusotomy in the early follow-up period. Otolaryngol Head Neck Surg. 2004;131(4):514–8.

    PubMed  Google Scholar 

  52. Abuzeid WM, et al. Endoscopic modified Lothrop procedure after failure of primary endoscopic sinus surgery: a meta-analysis. Int Forum Allergy Rhinol. 2018;8(5):605–13.

    PubMed  Google Scholar 

  53. Patel VS, et al. Equivalence in outcomes between Draf 2B vs Draf 3 frontal sinusotomy for refractory chronic frontal rhinosinusitis. Int Forum Allergy Rhinol. 2018;8(1):25–31.

    PubMed  Google Scholar 

  54. DeConde AS, et al. Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis. Laryngoscope. 2017;127(3):550–5.

    PubMed  Google Scholar 

  55. Jang DW, et al. Aspirin sensitivity does not compromise quality-of-life outcomes in patients with Samter’s triad. Laryngoscope. 2014;124(1):34–7.

    CAS  PubMed  Google Scholar 

  56. Bassiouni A, Wormald PJ. Role of frontal sinus surgery in nasal polyp recurrence. Laryngoscope. 2013;123(1):36–41.

    PubMed  Google Scholar 

  57. Morrissey DK, et al. Outcomes of modified endoscopic Lothrop in aspirin-exacerbated respiratory disease with nasal polyposis. Int Forum Allergy Rhinol. 2016;6(8):820–5.

    PubMed  Google Scholar 

  58. Georgalas C, et al. Long terms results of Draf type III (modified endoscopic Lothrop) frontal sinus drainage procedure in 122 patients: a single centre experience. Rhinology. 2011;49(2):195–201.

    CAS  PubMed  Google Scholar 

  59. Ye T, et al. Frontal ostium neo-osteogenesis and patency after Draf III procedure: a computer-assisted study. Int Forum Allergy Rhinol. 2014;4(9):739–44.

    PubMed  Google Scholar 

  60. Schlosser RJ, et al. The endoscopic modified Lothrop: long-term follow-up on 44 patients. Am J Rhinol. 2002;16(2):103–8.

    PubMed  Google Scholar 

  61. Conger BT Jr, Riley K, Woodworth BA. The Draf III mucosal grafting technique: a prospective study. Otolaryngol Head Neck Surg. 2012;146(4):664–8.

    PubMed  Google Scholar 

  62. Rotenberg BW, et al. Postoperative care for Samter’s triad patients undergoing endoscopic sinus surgery: a double-blinded, randomized controlled trial. Laryngoscope. 2011;121(12):2702–5.

    PubMed  Google Scholar 

  63. Chen XZ, et al. The effects of nasal irrigation with various solutions after endoscopic sinus surgery: systematic review and meta-analysis. J Laryngol Otol. 2018;132(8):673–9.

    CAS  PubMed  Google Scholar 

  64. Subramanian HN, Schechtman KB, Hamilos DL. A retrospective analysis of treatment outcomes and time to relapse after intensive medical treatment for chronic sinusitis. Am J Rhinol. 2002;16(6):303–12.

    PubMed  Google Scholar 

  65. Farag AA, et al. Single-blind randomized controlled trial of surfactant vs hypertonic saline irrigation following endoscopic endonasal surgery. Int Forum Allergy Rhinol. 2013;3(4):276–80.

    PubMed  Google Scholar 

  66. Achilles N, Mosges R. Nasal saline irrigations for the symptoms of acute and chronic rhinosinusitis. Curr Allergy Asthma Rep. 2013;13(2):229–35.

    PubMed  Google Scholar 

  67. Liang KL, et al. Impact of pulsatile nasal irrigation on the prognosis of functional endoscopic sinus surgery. J Otolaryngol Head Neck Surg. 2008;37(2):148–53.

    PubMed  Google Scholar 

  68. Talbot AR, Herr TM, Parsons DS. Mucociliary clearance and buffered hypertonic saline solution. Laryngoscope. 1997;107(4):500–3.

    CAS  PubMed  Google Scholar 

  69. Principi N, Esposito S. Nasal irrigation: an imprecisely defined medical procedure. Int J Environ Res Public Health. 2017;14(5):516.

    PubMed Central  Google Scholar 

  70. Naraghi M, et al. Improvement of sinonasal mucociliary function by endoscopic sinus surgery in patients with chronic rhinosinusitis. Am J Otolaryngol. 2018;39(6):707–10.

    PubMed  Google Scholar 

  71. Harvey RJ, et al. Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation. Otolaryngol Head Neck Surg. 2008;139(1):137–42.

    PubMed  Google Scholar 

  72. Olson DE, Rasgon BM, Hilsinger RL Jr. Radiographic comparison of three methods for nasal saline irrigation. Laryngoscope. 2002;112(8 Pt 1):1394–8.

    PubMed  Google Scholar 

  73. Pynnonen MA, et al. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Arch Otolaryngol Head Neck Surg. 2007;133(11):1115–20.

    PubMed  Google Scholar 

  74. Salib RJ, et al. A prospective randomised single-blinded clinical trial comparing the efficacy and tolerability of the nasal douching products Sterimar and Sinus Rinse following functional endoscopic sinus surgery. Clin Otolaryngol. 2013;38(4):297–305.

    CAS  PubMed  Google Scholar 

  75. Gantz O, et al. Sinus irrigation penetration after balloon sinuplasty vs functional endoscopic sinus surgery in a cadaveric model. Int Forum Allergy Rhinol. 2019;9(9):953–7.

    PubMed  Google Scholar 

  76. Craig JR, et al. Cadaveric validation study of computational fluid dynamics model of sinus irrigations before and after sinus surgery. Int Forum Allergy Rhinol. 2016;6(4):423–8.

    PubMed  PubMed Central  Google Scholar 

  77. Singhal D, et al. Effect of head position and surgical dissection on sinus irrigant penetration in cadavers. Laryngoscope. 2010;120(12):2528–31.

    PubMed  Google Scholar 

  78. Zhao K, et al. Sinus irrigations before and after surgery-visualization through computational fluid dynamics simulations. Laryngoscope. 2016;126(3):E90–6.

    PubMed  Google Scholar 

  79. Craig JR, Palmer JN, Zhao K. Computational fluid dynamic modeling of nose-to-ceiling head positioning for sphenoid sinus irrigation. Int Forum Allergy Rhinol. 2017;7(5):474–9.

    PubMed  PubMed Central  Google Scholar 

  80. Inthavong K, et al. Characterization of nasal irrigation flow from a squeeze bottle using computational fluid dynamics. Int Forum Allergy Rhinol. 2020;10(1):29–40.

    PubMed  Google Scholar 

  81. Govindaraju R, et al. Extent of maxillary sinus surgery and its effect on instrument access, irrigation penetration, and disease clearance. Int Forum Allergy Rhinol. 2019;9(10):1097–104.

    PubMed  Google Scholar 

  82. Snidvongs K, et al. Sinus surgery and delivery method influence the effectiveness of topical corticosteroids for chronic rhinosinusitis: systematic review and meta-analysis. Am J Rhinol Allergy. 2013;27(3):221–33.

    PubMed  PubMed Central  Google Scholar 

  83. Lildholdt T, Rundcrantz H, Lindqvist N. Efficacy of topical corticosteroid powder for nasal polyps: a double-blind, placebo-controlled study of budesonide. Clin Otolaryngol Allied Sci. 1995;20(1):26–30.

    CAS  PubMed  Google Scholar 

  84. Snidvongs K, et al. Topical steroid for chronic rhinosinusitis without polyps. Cochrane Database Syst Rev. 2011;8:CD009274.

    Google Scholar 

  85. Snidvongs K, et al. Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2012;2(5):415–21.

    PubMed  Google Scholar 

  86. Huang ZZ, et al. Budesonide nasal irrigation improved Lund-Kennedy endoscopic score of chronic rhinosinusitis patients after endoscopic sinus surgery. Eur Arch Otorhinolaryngol. 2019;276(5):1397–403.

    PubMed  Google Scholar 

  87. Joe SA, Thambi R, Huang J. A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2008;139(3):340–7.

    PubMed  Google Scholar 

  88. Harvey RJ, et al. Corticosteroid nasal irrigations are more effective than simple sprays in a randomized double-blinded placebo-controlled trial for chronic rhinosinusitis after sinus surgery. Int Forum Allergy Rhinol. 2018;8(4):461–70.

    PubMed  Google Scholar 

  89. Harvey RJ, et al. Fluid residuals and drug exposure in nasal irrigation. Otolaryngol Head Neck Surg. 2009;141(6):757–61.

    PubMed  Google Scholar 

  90. Neubauer PD, Schwam ZG, Manes RP. Comparison of intranasal fluticasone spray, budesonide atomizer, and budesonide respules in patients with chronic rhinosinusitis with polyposis after endoscopic sinus surgery. Int Forum Allergy Rhinol. 2016;6(3):233–7.

    PubMed  Google Scholar 

  91. Lindqvist N, et al. Long-term safety and efficacy of budesonide nasal aerosol in perennial rhinitis. A 12-month multicentre study. Allergy. 1986;41(3):179–86.

    CAS  PubMed  Google Scholar 

  92. Pipkorn U, et al. Long-term safety of budesonide nasal aerosol: a 5.5-year follow-up study. Clin Allergy. 1988;18(3):253–9.

    CAS  PubMed  Google Scholar 

  93. Soudry E, et al. Safety analysis of long-term budesonide nasal irrigations in patients with chronic rhinosinusitis post endoscopic sinus surgery. Int Forum Allergy Rhinol. 2016;6(6):568–72.

    PubMed  Google Scholar 

  94. Yoon HY, et al. Post-operative corticosteroid irrigation for chronic rhinosinusitis after endoscopic sinus surgery: a meta-analysis. Clin Otolaryngol. 2018;43(2):525–32.

    CAS  PubMed  Google Scholar 

  95. Patel ZM, et al. Surgical therapy vs continued medical therapy for medically refractory chronic rhinosinusitis: a systematic review and meta-analysis. Int Forum Allergy Rhinol. 2017;7(2):119–27.

    PubMed  Google Scholar 

  96. Smith KA, et al. Endoscopic sinus surgery compared to continued medical therapy for patients with refractory chronic rhinosinusitis. Int Forum Allergy Rhinol. 2014;4(10):823–7.

    PubMed  PubMed Central  Google Scholar 

  97. Smith TL, et al. Determinants of outcomes of sinus surgery: a multi-institutional prospective cohort study. Otolaryngol Head Neck Surg. 2010;142(1):55–63.

    PubMed  PubMed Central  Google Scholar 

  98. Smith TL, et al. Long-term outcomes of endoscopic sinus surgery in the management of adult chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019;9(8):831–41.

    PubMed  PubMed Central  Google Scholar 

  99. DeConde AS, et al. Outcomes of complete vs targeted approaches to endoscopic sinus surgery. Int Forum Allergy Rhinol. 2015;5(8):691–700.

    PubMed  PubMed Central  Google Scholar 

  100. Abuzeid WM, et al. Outcomes of chronic frontal sinusitis treated with ethmoidectomy: a prospective study. Int Forum Allergy Rhinol. 2016;6(6):597–604.

    PubMed  PubMed Central  Google Scholar 

  101. Chester AC, Antisdel JL, Sindwani R. Symptom-specific outcomes of endoscopic sinus surgery: a systematic review. Otolaryngol Head Neck Surg. 2009;140(5):633–9.

    PubMed  Google Scholar 

  102. DeConde AS, et al. Investigation of change in cardinal symptoms of chronic rhinosinusitis after surgical or ongoing medical management. Int Forum Allergy Rhinol. 2015;5(1):36–45.

    PubMed  Google Scholar 

  103. Van Gerven L, et al. Lack of long-term add-on effect by montelukast in postoperative chronic rhinosinusitis patients with nasal polyps. Laryngoscope. 2018;128(8):1743–51.

    PubMed  Google Scholar 

  104. Briner HR, Jones N, Simmen D. Olfaction after endoscopic sinus surgery: long-term results. Rhinology. 2012;50(2):178–84.

    CAS  PubMed  Google Scholar 

  105. Oka H, et al. Olfactory changes after endoscopic sinus surgery in patients with chronic rhinosinusitis. Auris Nasus Larynx. 2013;40(5):452–7.

    PubMed  Google Scholar 

  106. Gupta D, et al. Impact of endoscopic sinus surgery on olfaction and use of alternative components in odor threshold measurement. Am J Rhinol Allergy. 2015;29(4):e117–20.

    PubMed  Google Scholar 

  107. Gudziol V, et al. Olfaction and sinonasal symptoms in patients with CRSwNP and AERD and without AERD: a cross-sectional and longitudinal study. Eur Arch Otorhinolaryngol. 2017;274(3):1487–93.

    CAS  PubMed  Google Scholar 

  108. Soler ZM, et al. Olfactory-specific quality of life outcomes after endoscopic sinus surgery. Int Forum Allergy Rhinol. 2016;6(4):407–13.

    PubMed  Google Scholar 

  109. Zi XX, et al. Olfactory change pattern after endoscopic sinus surgery in chronic rhinosinusitis with olfactory dysfunction. J Coll Physicians Surg Pak. 2018;28(8):612–7.

    PubMed  Google Scholar 

  110. Wong EH, et al. Patient-reported olfaction improves following outside-in Draf III frontal sinus surgery for chronic rhinosinusitis. Laryngoscope. 2019;129(1):25–30.

    PubMed  Google Scholar 

  111. Katotomichelakis M, et al. Olfactory dysfunction and asthma as risk factors for poor quality of life in upper airway diseases. Am J Rhinol Allergy. 2013;27(4):293–8.

    PubMed  Google Scholar 

  112. Kohli P, et al. Olfactory outcomes after endoscopic sinus surgery for chronic rhinosinusitis: a meta-analysis. Otolaryngol Head Neck Surg. 2016;155(6):936–48.

    PubMed  Google Scholar 

  113. Kern RC. Chronic sinusitis and anosmia: pathologic changes in the olfactory mucosa. Laryngoscope. 2000;110(7):1071–7.

    CAS  PubMed  Google Scholar 

  114. Schlosser RJ, et al. Burden of illness: a systematic review of depression in chronic rhinosinusitis. Am J Rhinol Allergy. 2016;30(4):250–6.

    PubMed  PubMed Central  Google Scholar 

  115. Katotomichelakis M, et al. Demographic correlates of anxiety and depression symptoms in chronic sinonasal diseases. Int J Psychiatry Med. 2014;48(2):83–94.

    PubMed  Google Scholar 

  116. Litvack JR, Mace J, Smith TL. Role of depression in outcomes of endoscopic sinus surgery. Otolaryngol Head Neck Surg. 2011;144(3):446–51.

    PubMed  PubMed Central  Google Scholar 

  117. Schlosser RJ, et al. Depression-specific outcomes after treatment of chronic rhinosinusitis. JAMA Otolaryngol Head Neck Surg. 2016;142(4):370–6.

    PubMed  PubMed Central  Google Scholar 

  118. Alt JA, et al. Sleep quality outcomes after medical and surgical management of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2017;7(2):113–8.

    PubMed  Google Scholar 

  119. Adams KN, et al. Self-reported anxiety and depression unchanged after endoscopic sinus surgery for chronic rhinosinusitis. Rhinology. 2018;56(3):234–40.

    CAS  PubMed  Google Scholar 

  120. Ospina J, et al. The impact of comorbid depression in chronic rhinosinusitis on post-operative sino-nasal quality of life and pain following endoscopic sinus surgery. J Otolaryngol Head Neck Surg. 2019;48(1):18.

    PubMed  PubMed Central  Google Scholar 

  121. Caulley L, et al. Direct costs of adult chronic rhinosinusitis by using 4 methods of estimation: results of the US medical expenditure panel survey. J Allergy Clin Immunol. 2015;136(6):1517–22.

    PubMed  Google Scholar 

  122. Smith KA, Orlandi RR, Rudmik L. Cost of adult chronic rhinosinusitis: a systematic review. Laryngoscope. 2015;125(7):1547–56.

    PubMed  Google Scholar 

  123. Scangas GA, et al. Cost utility analysis of endoscopic sinus surgery for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(6):582–9.

    PubMed  Google Scholar 

  124. Scangas GA, et al. The impact of asthma on the cost effectiveness of surgery for chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2017;7(11):1035–44.

    PubMed  Google Scholar 

  125. Rudmik L, et al. Productivity costs decrease after endoscopic sinus surgery for refractory chronic rhinosinusitis. Laryngoscope. 2016;126(3):570–4.

    PubMed  Google Scholar 

  126. Rudmik L, et al. Economic evaluation of endoscopic sinus surgery versus continued medical therapy for refractory chronic rhinosinusitis. Laryngoscope. 2015;125(1):25–32.

    PubMed  Google Scholar 

  127. Ehnhage A, et al. Functional endoscopic sinus surgery improved asthma symptoms as well as PEFR and olfaction in patients with nasal polyposis. Allergy. 2009;64(5):762–9.

    CAS  PubMed  Google Scholar 

  128. Ehnhage A, et al. One year after endoscopic sinus surgery in polyposis: asthma, olfaction, and quality-of-life outcomes. Otolaryngol Head Neck Surg. 2012;146(5):834–41.

    PubMed  Google Scholar 

  129. Olsson P, et al. Quality of life is improved by endoscopic surgery and fluticasone in nasal polyposis with asthma. Rhinology. 2010;48(3):325–30.

    CAS  PubMed  Google Scholar 

  130. Nishioka GJ, et al. Functional endoscopic sinus surgery in patients with chronic sinusitis and asthma. Otolaryngol Head Neck Surg. 1994;110(6):494–500.

    CAS  PubMed  Google Scholar 

  131. Dunlop G, Scadding GK, Lund VJ. The effect of endoscopic sinus surgery on asthma: management of patients with chronic rhinosinusitis, nasal polyposis, and asthma. Am J Rhinol. 1999;13(4):261–5.

    CAS  PubMed  Google Scholar 

  132. Senior BA, et al. Long-term impact of functional endoscopic sinus surgery on asthma. Otolaryngol Head Neck Surg. 1999;121(1):66–8.

    CAS  PubMed  Google Scholar 

  133. Dejima K, et al. A clinical study of endoscopic sinus surgery for sinusitis in patients with bronchial asthma. Int Arch Allergy Immunol. 2005;138(2):97–104.

    PubMed  Google Scholar 

  134. Ikeda K, et al. Endoscopic sinus surgery improves pulmonary function in patients with asthma associated with chronic sinusitis. Ann Otol Rhinol Laryngol. 1999;108(4):355–9.

    CAS  PubMed  Google Scholar 

  135. Dunlop W, Heron L, Fox G, Greaney M. Budget impact analysis of a fixed-dose combination of fluticasone propionate and formoterol fumarate (FP/FORM) in a pressurized metered-dose inhaler (pMDI) for asthma. Adv Ther. 2013;30(10):933–44.

    CAS  PubMed  Google Scholar 

  136. Vashishta R, et al. A systematic review and meta-analysis of asthma outcomes following endoscopic sinus surgery for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013;3(10):788–94.

    PubMed  Google Scholar 

  137. Rix I, et al. Management of chronic rhinosinusitis with nasal polyps and coexisting asthma: a systematic review. Am J Rhinol Allergy. 2015;29(3):193–201.

    PubMed  Google Scholar 

  138. Sakalar EG, et al. Aspirin-exacerbated respiratory disease and current treatment modalities. Eur Arch Otorhinolaryngol. 2017;274(3):1291–300.

    PubMed  Google Scholar 

  139. Berges-Gimeno MP, Simon RA, Stevenson DD. Long-term treatment with aspirin desensitization in asthmatic patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2003;111(1):180–6.

    CAS  PubMed  Google Scholar 

  140. Klimek L, Pfaar O. Aspirin intolerance: does desensitization alter the course of the disease? Immunol Allergy Clin N Am. 2009;29(4):669–75.

    CAS  Google Scholar 

  141. Lee RU, Stevenson DD. Aspirin-exacerbated respiratory disease: evaluation and management. Allergy Asthma Immunol Res. 2011;3(1):3–10.

    CAS  PubMed  Google Scholar 

  142. McMains KC, Kountakis SE. Medical and surgical considerations in patients with Samter’s triad. Am J Rhinol. 2006;20(6):573–6.

    PubMed  Google Scholar 

  143. Huang GX, et al. Sinus surgery improves lower respiratory tract reactivity during aspirin desensitization for AERD. J Allergy Clin Immunol Pract. 2019;7(5):1647–9.

    PubMed  PubMed Central  Google Scholar 

  144. Cho KS, et al. Long-term sinonasal outcomes of aspirin desensitization in aspirin exacerbated respiratory disease. Otolaryngol Head Neck Surg. 2014;151(4):575–81.

    PubMed  Google Scholar 

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Li, K., Patel, V., Abuzeid, W.M. (2020). Asthma and Chronic Rhinosinusitis: Surgical Management and Outcomes. In: Gudis, D., Schlosser, R. (eds) The Unified Airway. Springer, Cham. https://doi.org/10.1007/978-3-030-50330-7_6

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