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Mapping the Radiogenome of Human Cancers

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Molecular Targeted Radiosensitizers

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Precision oncology enables individualized treatment decisions on the basis of patient - and tumor-specific features. Despite growing evidence that inter-patient variation in tumor genomes affects treatment responses after radiation therapy, patients receiving these treatments continue to be treated with the same or similar doses. Herein, we discuss past, contemporary, and potential future forays into the mapping of the radiogenome of humans and their tumors. We contend that the incorporation of genomic information into radiation treatment approaches represents a critical step toward the individualization of radiation dose, which considers both treatment-related toxicity as well as tumor control probability. Specifically, we describe the role of somatic and germline genetic features on radiation tumor sensitivity and normal tissue toxicity. We also discuss potential barriers for the implementation of genomic predictors in clinical practices and strategies to overcome these barriers. The following discourse seeks to inform and guide the future use of genotype-directed radiation dose delivery and targeted radiosensitization.

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Author notes

  1. Priyanka Gopal and Jessica A. Castrillon contributed equally to this work.

Authors and Affiliations

  1. Department of Radiation Oncology, Northwestern Memorial Hospital, Northwestern University, Chicago, IL, USA

    Priyanka Gopal & Mohamed E. Abazeed

  2. Department of Translational Hematology Oncology Research, Cleveland Clinic, Cleveland, OH, USA

    Jessica A. Castrillon

Authors
  1. Priyanka Gopal
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  2. Jessica A. Castrillon
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  3. Mohamed E. Abazeed
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Correspondence to Mohamed E. Abazeed .

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Editors and Affiliations

  1. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Henning Willers

  2. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA

    Iris Eke

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Gopal, P., Castrillon, J.A., Abazeed, M.E. (2020). Mapping the Radiogenome of Human Cancers. In: Willers, H., Eke, I. (eds) Molecular Targeted Radiosensitizers. Cancer Drug Discovery and Development. Humana, Cham. https://doi.org/10.1007/978-3-030-49701-9_3

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  • DOI: https://doi.org/10.1007/978-3-030-49701-9_3

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