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Evaluation of the Effect of a PCL/nanoSiO\(_2\) Implant on Bone Tissue Regeneration Using X-ray Micro-Computed Tomography

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Information Technology in Biomedicine

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 1186))

Abstract

This paper evaluates the regeneration process of large bone defects filled with a highly porous (nano) composite implant. A polycaprolactone—based scaffold modified with nanometric silica was introduced into bone defects created in the distal femoral epiphyses of rabbits. The bone tissue regeneration process was evaluated 1, 2, 3 and 6 months after implantation. Empty bone defects served as a control. The osseointegration process was evaluated using the parameters of cancellous bone microstructure. 16 bone tissue samples were imaged using X-ray micro-computed tomography (XMT). There were 1000 2D images in each measurement, which in total gave 16000 2D images. In the end, in this work 200 2D images were picked for detailed analysis. The studies have shown that the PCL/nanoSiO\(_2\) composite implant supports successfully the initial phase of bone regeneration. In each of the reference periods, a greater volume of new bone tissue was observed for the implanted samples.

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Acknowledgements

The authors thank Dr inż. Ewa Stodolak-Zych from AGH University of Science and Technology in Krakow, Faculty of Materials Science and Ceramics, Department of Biomaterials, for providing materials for research and valuable consultations.

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Authors and Affiliations

  1. Faculty of Science and Technology, Institute of Biomedical Engineering, University of Silesia in Katowice, ul. Będzińska 39, Sosnowiec, 41-200, Poland

    Magdalena Jędzierowska, Robert Koprowski & Zygmunt Wróbel

  2. X-ray Microtomography Lab, Department of Computer Biomedical Systems, Faculty of Computer and Materials Science, Institute of Computer Science, University of Silesia, Sosnowiec, 41-200, Poland

    Marcin Binkowski

Authors
  1. Magdalena Jędzierowska
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  4. Zygmunt Wróbel
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Corresponding author

Correspondence to Magdalena Jędzierowska .

Editor information

Editors and Affiliations

  1. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Ewa Pietka

  2. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Pawel Badura

  3. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Jacek Kawa

  4. Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice, Poland

    Wojciech Wieclawek

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Jędzierowska, M., Binkowski, M., Koprowski, R., Wróbel, Z. (2021). Evaluation of the Effect of a PCL/nanoSiO\(_2\) Implant on Bone Tissue Regeneration Using X-ray Micro-Computed Tomography. In: Pietka, E., Badura, P., Kawa, J., Wieclawek, W. (eds) Information Technology in Biomedicine. Advances in Intelligent Systems and Computing, vol 1186. Springer, Cham. https://doi.org/10.1007/978-3-030-49666-1_9

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