Abstract
Allergic contact dermatitis from cosmetics is very common, with perfume components, preservatives, hair dyes, but currently also acrylates and methacrylates in nail products as the main culprits. Any other cosmetic ingredient can be involved though, and the literature regarding new cosmetic allergens is on the rise. Beside the baseline and cosmetic series, patch tests with the personal products used, and if possible, all the ingredients that are present in them, should be performed. These tests do not necessarily allow the identification of the culprit allergen, which may be due to unsuitable test concentrations or vehicles, especially since nano- or micro-encapsulated ingredients are increasingly used in cosmetic products, thus enhancing skin penetration. In addition, commercially available patch-test preparations do not always contain the responsible sensitizing culprits.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
de Groot A. Monographs in contact allergy. II Fragrances and essential oils. Boca Raton, Fl: CRC Press; 2019.
de Groot A. Monographs in contact allergy: non-fragrance allergens in cosmetics (Parts 1 and 2). Boca Raton, Fl: CRC Press; 2018.
Alinaghi F, Bennike NH, Egeberg A, et al. Prevalence of contact allergy in the general population: a systematic review and meta-analysis. Contact Dermatitis. 2019;80:77–85.
Bennike NH, Zachariae C, Johansen JD. Trends in contact allergy to fragrance mix I in consecutive Danish patients with eczema from 1986 to 2015: a cross-sectional study. Br J Dermatol. 2017;176:1035–41.
Bennike NH, Zachariae C, Johansen JD. Non-mix fragrances are top sensitizers in consecutive dermatitis patients—a cross-sectional study of the 26 EU-labelled fragrance allergens. Contact Dermatitis. 2017;77:270–9.
Bennike NH, Zachariae C, Johansen JD. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics. Contact Dermatitis. 2019;80:325–7.
Goodier MC, Zhang A, Nikle AB, et al. Use of essential oils: a general population survey. Contact Dermatitis. 2019;80:391–3.
Griggs J, Almohanna H, Ahmed A, Ren S, Tosti A. “Fresh Breath” on toothpaste: peppermint as cause of cheilitis. Dermatitis. 2019;30:74–5.
Kroona L, Isaksson M, Ahlgren C, et al. Carvone contact allergy in Southern Sweden: a 21-year retrospective study. Acta Derm Venereol. 2018;98:938–42.
Dittmar D, Schuttelaar MLA. Contact sensitization to hydroperoxides of limonene and linalool: results of consecutive patch testing and clinical relevance. Contact Dermatitis. 2019;80:101–9.
Gatica-Ortega M-E, Pastor-Nieto M-A, Schoendorff-Ortega C, et al. Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products. Contact Dermatitis. 2018;3:230–3.
Bennike NH, Palangi L, Christensson JB, et al. Allergic contact dermatitis caused by hydroperoxides of limonene and dose-response relationship—a repeated open application test (ROAT) study. Contact Dermatitis. 2019;80:208–16.
Tanaka S, Royds C, Buckley D, et al. Contact allergy to isoeugenol and its derivatives: problems with allergen substitution. Contact Dermatitis. 2004;51:288–91.
Hagvall L, Niklasson I, Luthman K, Karlberg A-T. Can the epoxides of cinnamyl alcohol and cinnamal show new cases of contact allergy? Contact Dermatitis. 2018;6:399–405.
Hagvall L, Bråred Christensson J. Cross-reactivity between citral and geraniol—can it be attributed to oxidized geraniol? Contact Dermatitis. 2014;71:280–8.
Hagvall L, Bruze M, Engfeldt M, et al. A multicentre study by the Swedish Contact Dermatitis Research Group. Contact Dermatitis. 2018;79:232–8.
Jack AR, Norris PL, Storrs FJ. Allergic contact dermatitis to plant extracts in cosmetics. Semin Cutan Med Surg. 2013;32:140–6.
Paulsen E, Andersen KE. Colophonium and compositae mix as markers of fragrance allergy: cross-reactivity between fragrance terpenes, colophonium and compositae plant extracts. Contact Dermatitis. 2005;53:285–91.
Nardelli A, Thijs L, Janssen K, Goossens A. Rosa centifolia in a ‘non-scented’ moisturizing body lotion as a cause of allergic contact dermatitis. Contact Dermatitis. 2009;61:306–9.
Ochando-Ibernon G, Schneller-Pavelescu L, Silvestre-Salvador JF. Allergic contact dermatitis caused by “Rosa mosqueta” oil. Contact Dermatitis. 2018;79:259–60.
Gallo R, Pastorini C, Gasparinin G, et al. Scutellaria baicalensis extract: a novel botanical allergen in cosmetic products. Contact Dermatitis. 2016;75:387–8.
Dehavay F, Kolivras A, Scheers C. Local and systemic adverse skin reactions following the use of herbal products believed to contain Nigella sativa seeds and oil. Contact Dermatitis. 2019;80:176–7.
Malinauskiene L, Linauskiene K, Černiauskas K, Chomičiene A. Bakuchiol—a new allergen in cosmetics. Contact Dermatitis. 2019;80:398–9.
Kimyon RS, Liou YL, Schlarbaum JP, Warshaw EM. Allergic contact dermatitis to Licorice root extract. Dermatitis. 2019;30:227–8.
Wuyts L, Van Hoof T, Lambert J, Aerts O. Allergic contact dermatitis caused by aftershave creams containing Glycyrrhiza inflate. Contact Dermatitis. 2017;77:49–51.
Oiso N, Tatebayashi M, Hoshiyama Y, Kawada A. Allergic contact dermatitis caused by arbutin and dipotassium glycyrrhizate in skin-lightening products? Contact Dermatitis. 2017;77:51–3.
Chaubal TV, Bapat RA, Bapat PR. Allergic contact stomatitis caused by Salvadora persica in toothpaste. Contact Dermatitis. 2017;77:325–6.
Lauriola MM, Corazza M. Allergic contact dermatitis caused by argan oil, neem oil, and Mimosa tenuiflora. Contact Dermatitis. 2016;75:388–90.
Romita P, Calogiuri G, Bellino M, et al. Allergic contact dermatitis caused by neem oil: an underrated allergen? Contact Dermatitis. 2019. https://doi.org/10.1111/cod.13256.
Leheron C, Bourrier T, Albertini M, Giovannini-Chami L. Immediate contact urticaria caused by hydrolysed wheat proteins in a child via maternal skin contact sensitization. Contact Dermatitis. 2013;68:379–80.
Chinuki Y, Takahashi H, Dekio I, et al. Higher allergenicity of high molecular weight hydrolysed wheat protein in cosmetics for percutaneous sensitization. Contact Dermatitis. 2013;68:86–93.
Nakamura M, Yagami A, Hara K, et al. Evaluation of the cross-reactivity of antigens in Glupearl 19S and other hydrolysed wheat proteins in cosmetics. Contact Dermatitis. 2016;74:346–52.
Burnett C, Bergfeld WF, Belsito DV, et al. Safety Assessment of hydrolyzed wheat protein and hydrolyzed wheat gluten as used in cosmetics. Int J Toxicol. 2018;37(1-suppl):55S–66S.
Schwensen JF, White IR, Thyssen JP, et al. Failures in risk assessment and risk management for cosmetic preservatives in Europe and the impact on public health. Contact Dermatitis. 2015;37:133–41.
Uter W, Aalto-Korte K, Agner T, et al. The epidemic of methylisothiazolinone in Europe: follow-up on changing exposure. J Eur Acad Derm Venereol. 2019 (to be published).
Kamstrup MR, Bandier J, Johansen JD, Thyssen JP. Contact allergy to methyldibromo glutaronitrile is still of clinical relevance. Contact Dermatitis. 2017;77:250–1.
Giménez-Arnau AM, Deza G, Bauer A, et al. Contact allergy to preservatives: ESSCA results with the baseline series, 2009–2012. J Eur Acad Dermatol Venereol. 2017;31:664–71.
Rembe JD, Fromm-Dornieden C, Schäfer N, et al. Comparing two polymeric biguanides: chemical distinction, antiseptic efficacy and cytotoxicity of polyaminopropyl biguanide and polyhexamethylene biguanide. J Med Microbiol. 2016;65:867–76.
Leysen J, Goossens A, Lambert J, Aerts O. Polyhexamethylene biguanide is a relevant sensitizer in wet wipes. Contact Dermatitis. 2014;70:323–5.
Creytens K, Faber M, Aerts O, Goosens A. Severe contact urticaria syndrome from wipes for intimate hygiene. Contact Dermatitis. 2014;71:307–9.
Kautz O, Schumann H, Degerbeck F, et al. Severe anaphylaxis to the antiseptic polyhexanide. Allergy. 2010;65:1068–70.
Batista M, Morgado F, Gonçalo M. Patch test reactivity to iodopropynyl butylcarbamate in consecutive patients during a period of 7 years. Contact Dermatitis. 2019;81:54–5.
Deza G, Giménez-Arnau AM. Allergic contact dermatitis in preservatives: current standing and future options. Curr Opin Allergy Clin Immunol. 2017;17:263–8.
Vanhoutte C, Goossens A, Gilissen L, et al. Concomitant contact-allergic reactions to iodopropynyl butylcarbamate and iodine. Contact Dermatitis. 2019;81:17–23.
Doi T, Takeda A, Asada A, Kajimura K. Characterization of the decomposition of compounds derived from imidazolidinyl and diazolidinyl urea in cosmetics and patch test materials. Contact Dermatitis. 2012;67:284–91.
Fasth IM, Ulrich NH, Johansen JD. Ten-year trends in contact allergy to formaldehyde and formaldehyde-releasers. Contact Dermatitis. 2018;79:263–9.
Nikle A, Ericson M, Warshaw E. Formaldehyde release from personal care products: chromotropic acid method analysi. Dermatitis. 2019;30:67–73.
Halla N, Fernandes IP, Heleno SA, et al. cosmetics preservation: a review on present strategies. Molecules. 2018;23. pii: E1571.
Hagen SL, Warshaw E. The latest occult “Hypoallergenic” Allergen: Ethylhexylglycerin. Dermatitis. 2017;28:220–2.
Werbrouck J, Lambrecht C, Goossens A. C12-15 alkyl benzoate: a new cosmetic allergen? Contact Dermatitis. 2015;73:249–50.
De Groot A, Rustemeyer T, Hissink D, Bakker M. Contact allergy to capryloyl salicylic acid. Contact Dermatitis. 2014;71:185–7.
Ackermann L, Virtanen H, Korhonen L, et al. An epidemic of allergic contact dermatitis caused by a new allergen, caprylhydroxamic acid, in moisturizers. Contact Dermatitis. 2017;77:159–62.
Mangodt EA, Dendooven E, De Fré C, et al. Capryloyl glycine: a polyfunctional cosmetic ingredient and potential skin sensitizer. Contact Dermatitis. 2019;80:400–2.
Jacob SE, Scheman A, McGowan MA. Propylene Glycol. Dermatitis. 2018;29:3–5.
Ralph N, Verma S, Merry S, et al. What is the relevance of contact allergy to sodium metabisulfite and which concentration of the allergen should we use? Dermatitis. 2015;26:162–5.
Sánchez T, Núñez Acevedo B, Rubio Flores C, Díaz-Díaz RM. Contact urticaria caused by tocopherol. Contact Dermatitis. 2018;79:395.
Mercader-Garcia P. Allergic contact dermatitis to 3-o-ethyl-L-ascorbic acid in skin-lightening creams. Dermatitis. 2017;28:89.
Sanz-Sánchez T, Valverde Garrido R, Maldonado Cid P, Díaz-Díaz RM. Allergic contact dermatitis caused by hydroxyacetophenone in a face cream. Contact Dermatitis. 2018;78:174–5.
Leysen J, Aerts O. Further evidence of thioctic acid (α-lipoic acid) being a strong cosmetic sensitizer. Contact Dermatitis. 2016;74:182–4.
Chouhan S, Sharma K, Guleria S. Antimicrobial activity of some essential oils-present status and future perspectives. Medicines (Basel). 2017;4. pii: E58.
Ferreira C, Rezende I, Guilherme A, et al. Allergic contact connubial dermatitis caused by hair products. Contact Dermatitis. 2019;80:186–7.
Romita P, Foti C, Mascia P, Guida S. Eyebrow allergic contact dermatitis caused by m-aminophenol and toluene-2,5-diamine secondary to a temporary black henna tattoo. Contact Dermatitis. 2018;79:51–2.
Vogel TA, Coenraads P-J, Schuttelaar M-LA. Allergic contact dermatitis presenting as severe and persistent blepharoconjunctivitis and centrofacial oedema after dyeing of eyelashes. Contact Dermatitis. 2014;71:304–6.
Schuttelaar MI, Dittmar D, Burgerhof JGM, et al. Cross-elicitation responses to 2-methoxy-p-phenylenediamine in p-phenylene-diamine allergic individuals: results from open use testing and diagnostic patch testing. Contact Dermatitis. 2018;79:288–94.
King T, Sabroe R, Holden C. Allergic contact dermatitis caused by 1-naphthol, a red coupler, in a purple permanent oxidative hair dye. Contact Dermatitis. 2018;79:99–100.
Hoekst M, van der Heide S, Coenraads P-J, Schuttelaar M-L. Anaphylaxis and severe systemic reactions caused by skin contact with persulfates in hair-bleaching products. Contact Dermatitis. 2012;66:317–22.
Wilkinson M, Solman L, Coenraads PJ, Goebel C. Immediate hypersensitivity to p-phenylenediamine. Contact Dermatitis. 2019;80:177–8.
Washio K, Ijuin K, Fukunaga A. Contact anaphylaxis caused by Basic Blue 99 in hair dye. Contact Dermatitis. 2017;77:122–3.
Nishioka K, Koizumi A, Takita Y. Allergic contact dermatitis caused by cysteamine hydrochloride in permanent wave agent—a new allergen for hairdressers in Japan. Contact Dermatitis. 2019;80:174–5.
Mestach L, Goossens A. Allergic contact dermatitis and nail damage mimicking psoriasis caused by nail hardeners. Contact Dermatitis. 2016;74:112–4.
Gatica-Ortega MA, Pastor-Nieto MA, Gil-Redondo R, et al. Non-occupational allergic contact dermatitis caused by long-lasting nail polish kits for home use: ‘the tip of the iceberg’. Contact Dermatitis. 2018;78:261–5.
Mendonca MMS, LaSenna C, Tosti A. Severe onychodystrophy due to allergic contact dermatitis from acrylic nails. Skin Appendage Disord. 2015;1:91–4.
Carr C, Liu M, Goff HW. Acrylate allergic contact dermatitis-induced lichen planus of the nail. Dermatitis. 2019;30:233–4.
Fernández-Canga P, Sánchez-Sambucety P, Valladares-Narganes L, et al. Lymphomatoid contact dermatitis induced by acrylates mimicking lymphomatoid papulosis. Dermatitis. 2018;29:167–8.
MCCarthy S, Flynn A, Bennett M, Bourke JF. “It’s not lupus, it’s your nails!” Contact Dermatitis. 2019;80:67–8.
Alamri A, Lill D, Summer B, et al. Artificial nail wearing: unexpected elicitor of allergic contact dermatitis, oral lichen planus and risky arthroplasty. Contact Dermatitis 2019 Feb 21. https://doi.org/10.1111/cod.13250. [Epub ahead of print].
Sato M, Inomata N, Aihara M. A case of contact dermatitis syndrome caused by Dermabond®, followed by contact dermatitis caused by false eyelash glue and Aron Alpha® glue: possibility of cross-reactions among cyanoacrylates. Contact Dermatitis. 2017;77:414–5.
Pesonen M, Kuuliala O, Henriks-Eckerman ML, Aalto-Korte K. Occupational allergic contact dermatitis caused by eyelash extension glues. Contact Dermatitis. 2012;67:307–8.
Lindström I, Suojalehto H, Henriks-Eckerman ML, Suuronen K. Occupational asthma and rhinitis caused by cyanoacrylate-based eyelash extension glues. Occup Med (Lond). 2013;63:294–7.
Hughes TM, Stone NM. Benzophenone 4: an emerging allergen in cosmetics and toiletries? Contact Dermatitis. 2007;56:153–6.
Spijker GT, Schuttelaar ML, Barkema L, et al. Anaphylaxis caused by topical application of a sunscreen containing benzophenone-3. Contact Dermatitis. 2008;59:248–9.
de Groot AC, Roberts DW. Contact and photocontact allergy to octocrylene: a review. Contact Dermatitis. 2014;70:193–204.
Romita P, Foti C, Hansel K, Stineni L. Photo-contact allergy to octocrylene: a decreasing trend? Contact Dermatitis. 2018;78:224–5.
Aerts O, Goossens A, Bervoets A, Lambert J. Almost missed it! Photo-contact allergy to octocrylene in a ketoprofen-sensitized subject. Dermatitis. 2016;27:33–4.
Matta MK, Zusterzeel R, Pilli NR, et al. Sunscreen active ingredients: a randomized clinical trial. JAMA. 2019. https://doi.org/10.1001/jama.2019.5586.
Ito K, Fujimura N, Uchida T, et al. Contact dermatitis with systemic reactions caused by cetearyl isononanoate. Contact Dermatitis. 2014;69:315–6.
Miura M, Isami M, Yagami A, Matsunaga K. Allergic contact cheilitis caused by ditrimethylolpropane triethylhexanoate in a lipstick. Contact Dermatitis. 2011;64:301–2.
Deswysen A-C, Dekeuleneer V, Goossens A, Baeck M. Allergic contact dermatitis caused by a nursing comfort balm: methyl glucose dioleate as the sensitizing ingredient. Contact Dermatitis. 2013;68:315–6.
Herbert VG, Spiro JM, Reich K, et al. Glyceryl (mono)caprylate—a new contact allergen. Contact Dermatitis. 2014;69:383–5.
Vandeweghe J, Decoster E, Lapeere H. First report of allergic contact dermatitis caused by sorbitan caprylate. Contact Dermatitis. 2018;78:162–4.
Al Ali A, Mireault J, Tremblay C, Sasseville D. Allergic contact dermatitis caused by pentaerythrityl tetracaprylate/tetracaprate. Contact Dermatitis. 2017;77:58–9.
Numata T, Okubo Y, Tsuboi R, et al. Allergic contact dermatitis caused by isopropyl lauroyl sarcosinate. Contact Dermatitis. 2019;80:58–9.
Kerre S, Goossens A. Allergic contact cheilitis caused by lauryl PCA. Contact Dermatitis. 2018;79:318–9.
Loranger C, Alfalah M, Ferrier Le Bouedec MC, Sasseville D. Alkyl glucosides in contact dermatitis. Dermatitis. 2017;28:5–13.
Sasseville D. Alkyl glucosides: 2017 “Allergen of the Year”. Dermatitis. 2017;28:296.
Boucneau F, Goossens A, Huygens S, Gilissen L. Arachidyl glucoside: Another cosmetic allergen. Contact Dermatitis. 2018;79:321–3.
Severin RK, Belsito DV. Patch testing with decyl and lauryl glucoside: how well does one screen for contact-allergic reactions to the other? Dermatitis. 2017;28:342–5.
Hagvall L, Bråred-Christensson J, Inerot A. Occupational contact dermatitis caused by sodium cocoamphopropionate in a liquid soap used in fast-food restaurants. Contact Dermatitis. 2014;71:122–4.
Skudlik C, Markthaler M, Swen MJ. Occupational contact allergy to sodium cocoamphoprop- ionate in a skin protection cream. Contact Dermatitis. 2018;4:295–6.
Scheman A, Te R. Contact allergy to cocamide diethanolamine and cross-reactions. Dermatitis. 2018;29:91–2.
Lucidarme N, Aerts O, Roelandts R, Goossens A. Hydroxyethylacrylate, a potential allergen in cosmetics. Contact Dermatitis. 2008;59:321.
Mukaijo J, Inomata N, Higashihira M, et al. Allergic contact dermatitis caused by 2-hydroxyethyl acrylate in a moisturizing face pack in a handmade acrylic accessory enthusiast. Contact Dermatitis. 2018;1–2. https://doi.org/10.1111/cod.13088.
Pastor-Nieto MA, Gatica-Ortega ME, Alcántara-Nicolás FD, et al. Allergic contact dermatitis resulting from cetyl PEG/PPG-10/1 dimethicone in a deodorant cream. Contact Dermatitis. 2018;78:236–9.
Waas RLV, Hill G. Allergic contact dermatitis caused by vinylpyrrolidone/eicosene copolymer in a sunscreen. Contact Dermatitis. 2019;80:63.
Kimyon RS, Liou YL, Schlarbaum JP, Hylwa SA. Everlasting liquid lipstick: reminder to patch test personal product. Dermatitis. 2019;30:78–9.
Goossens A, Drieghe J. Computer applications in contact allergy. Contact Dermatitis. 1998;38:51–2.
Gether L, Thyssen JP, Avnstorp C. ‘Allergyapp’—a novel app(lication) to detect contact allergens in cosmetic products. Contact Dermatitis. 2014;71:379–81.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Goossens, A. (2021). Contact Dermatitis Due to Cosmetics. In: Angelini, G., Bonamonte, D., Foti, C. (eds) Clinical Contact Dermatitis. Springer, Cham. https://doi.org/10.1007/978-3-030-49332-5_14
Download citation
DOI: https://doi.org/10.1007/978-3-030-49332-5_14
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-49331-8
Online ISBN: 978-3-030-49332-5
eBook Packages: MedicineMedicine (R0)