Abstract
Nearly all survivors of childhood cancer wish to have biological children in adulthood. Yet, cancer treatment may lead to a reduced fertile window and infertility. Especially due to possible organic late effects as a result of previous cancer treatment, survivors may be at additional risk for complications during pregnancy and labor. While generally courses of pregnancy are uncomplicated in the majority of survivors, mode of deliveries seem to represent an increased surveillance in these patients. Potential perinatal and health consequences for the offspring are summarized in this book chapter.
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References
Hohmann C, et al. Patient counselling on the risk of infertility and its impact on childhood cancer survivors: results from a national survey. J Psychosoc Oncol. 2011;29(3):274–85.
Balcerek M, et. al. Suspected Infertility After Treatment for Leukemia and Solid Tumors in Childhood and Adolescence. Dtsch Arztebl. Int. 2012;109(7):126–31.
Barton SE, et al. Infertility, infertility treatment, and achievement of pregnancy in female survivors of childhood cancer: a report from the childhood Cancer survivor study cohort. Lancet Oncol. 2013;14(9):873–81.
Byrne J, et al. Early menopause in long-term survivors of cancer during adolescence. Am J Obstet Gynecol. 1992;166(3):788–93.
Luke B, et al. Assisted reproductive technology use and outcomes among women with a history of cancerdagger. Hum Reprod. 2016;31(1):183–9.
Vernaeve V, et al. Endometrial receptivity after oocyte donation in recipients with a history of chemotherapy and/or radiotherapy. Hum Reprod. 2007;22(11):2863–7.
Donnez J, Dolmans MM. Fertility Preservation in Women. N Engl J Med. 2017;377:1657–65.
Kamiyama R, Funata N. A study of leukemic cell infiltration in the testis and ovary. Bull Tokyo Med Dent Univ. 1976;23(4):203–10.
Reid H, Marsden HB. Gonadal infiltration in children with leukaemia and lymphoma. J Clin Pathol. 1980;33(8):722–9.
Bastings L, et al. Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review. Hum Reprod Update. 2013;19(5):483–506.
Krotz SP, et al. In vitro maturation of oocytes via the pre-fabricated self-assembled artificial human ovary. J Assist Reprod Genet. 2010;27(12):743–50.
Hohmann C, et al. Re: induced abortions in Danish cancer survivors: a population-based cohort study. J Natl Cancer Inst. 2011;103(8):698.
Reulen RC, et al. Pregnancy outcomes among adult survivors of childhood cancer in the British Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2009;18(8):2239–47.
Reinmuth S, et al. Having children after surviving cancer in childhood or adolescence - results of a Berlin survey. Klin Padiatr. 2008;220(3):159–65.
Valachis A, et al. Safety of pregnancy after primary breast carcinoma in young women: a meta-analysis to overcome bias of healthy mother effect studies. Obstet Gynecol Surv. 2010;65(12):786–93.
Sankila R, et al. Survival of breast cancer patients after subsequent term pregnancy: “healthy mother effect”. Am J Obstet Gynecol. 1994;170(3):818–23.
Janerich DT. The fetal antigen hypothesis: cancers and beyond. Med Hypotheses. 2001;56(1):101–3.
Stensheim H, et al. Cause-specific survival for women diagnosed with cancer during pregnancy or lactation: a registry-based cohort study. J Clin Oncol. 2009;27(1):45–51.
van Oppen AC, et al. Cardiac output in normal pregnancy: a critical review. Obstet Gynecol. 1996;87(2):310–8.
ESC-guidelines “Guidelines for management of cardiovascular disease during pregnancy”. 2011.
Perloff JK. Congenital heart disease and pregnancy. Clin Cardiol. 1994;17(11):579–87.
Bar J, et al. Pregnancy outcome in women treated with doxorubicin for childhood cancer. Am J Obstet Gynecol. 2003;189(3):853–7.
Mueller BA, et al. Pregnancy outcomes in female childhood and adolescent cancer survivors: a linked cancer-birth registry analysis. Arch Pediatr Adolesc Med. 2009;163(10):879–86.
Lie Fong S, et al. Pregnancy outcome in female childhood cancer survivors. Hum Reprod. 2010;25(5):1206–12.
Lambertini M, et al. Exploring the safety of chemotherapy for treating breast cancer during pregnancy. Expert Opin Drug Saf. 2015;14(9):1395–408.
Irtan et al. Ovarian transposition in prebuscent and adolescent girls with cancer. Lancet Oncol. 2013;14: 601–8.
Critchley HO, et al. Abdominal irradiation in childhood; the potential for pregnancy. Br J Obstet Gynaecol. 1992;99(5):392–4.
Bath LE, et al. Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: response to sex steroid replacement. Br J Obstet Gynaecol. 1999;106(12):1265–72.
Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969;44(235):291–303.
Holm K, et al. Pubertal maturation of the internal genitalia—an ultrasound evaluation of 166 healthy girls. Ultrasound Obstet Gynecol. 1995;6(3):175–81.
Laursen EM, et al. Doppler assessment of flow velocity in the uterine artery during pubertal maturation. Ultrasound Obstet Gynecol. 1996;8(5):341–5.
Holm K, et al. Ultrasound B-mode changes in the uterus and ovaries and Doppler changes in the uterus after total body irradiation and allogeneic bone marrow transplantation in childhood. Bone Marrow Transplant. 1999;23(3):259–63.
Arrive L, et al. Radiation-induced uterine changes: MR imaging. Radiology. 1989;170(1 Pt 1):55–8.
Beneventi F, et al. Adolescent and adult uterine volume and uterine artery Doppler blood flow among subjects treated with bone marrow transplantation or chemotherapy in indiatric age: a case-control study. Fertil Steril. 2015;103(2):455–61.
Larsen EC, et al. Radiotherapy at a young age reduces uterine volume of childhood cancer survivors. Acta Obstet Gynecol Scand. 2004;83(1):96–102.
Norwitz ER, et al. Placenta percreta and uterine rupture associated with prior whole body radiation therapy. Obstet Gynecol. 2001;98(5 Pt 2):929–31.
Clark H, et al. Obstetric outcomes in cancer survivors. Obstet Gynecol. 2007;110(4):849–54.
Madanat-Harjuoja LM, et al. Preterm delivery among female survivors of childhood, adolescent and young adulthood cancer. Int J Cancer. 2010;127(7):1669–79.
Magelssen H, et al. Parenthood probability and pregnancy outcome in patients with a cancer diagnosis during adolescence and young adulthood. Hum Reprod. 2008;23(1):178–86.
Winther JF, et al. Spontaneous abortion in a Danish population-based cohort of childhood cancer survivors. J Clin Oncol. 2008;26(26):4340–6.
Reulen RC, et al. Pregnancy outcomes among adult survivors of childhood cancer in the British childhood cancer survivor study. Cancer Epidemiol Biomark Prev. 2009;18(8):2239–47.
Signorello LB, et al. Female survivors of childhood cancer: preterm birth and low birth weight among their children. J Natl Cancer Inst. 2006;98(20):1453–61.
Signorello LB, et al. Stillbirth and neonatal death in relation to radiation exposure before conception: a retrospective cohort study. Lancet. 2010;376(9741):624–30.
Sudour H, et al. Fertility and pregnancy outcome after abdominal irradiation that included or excluded the pelvis in childhood tumor survivors. Int J Radiat Oncol Biol Phys. 2010;76(3):867–73.
Teh WT, et al. The impact of uterine radiation on subsequent fertility and pregnancy outcomes. Biomed Res Int. 2014;2014:482968.
Sauer MV, et al. The demographic characterization of women participating in oocyte donation: a review of 300 consecutively performed cycles. Int J Gynaecol Obstet. 1994;45(2):147–51.
Mulvihill JJ, et al. Pregnancy outcome in cancer patients. Experience in a large cooperative group. Cancer. 1987;60(5): 1143-50.
Salooja N, et al. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet. 2001;358(9278):271–6.
Sanders JE, et al. Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood. 1996;87(7): 3045–52.
Nicholson HS, et al. Uterine anomalies in Wilms’ tumor survivors. Cancer. 1996;78(4):887–91.
Scottish Intercollegiate Guidelines Network (SIGN) 132: Long term follow up of survivors of childhood cancer 2013.
Melin J, et al. Adverse obstetric outcomes among early-onset cancer survivors in Finland. Obstet Gynecol. 2015;126(4):803–10.
McCullough L, et al. Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy. Cancer. 2010;116(20):4866–71.
Johnston K, et al. Failure to lactate: a possible late effect of cranial radiation. Pediatr Blood Cancer. 2008;50(3):721–2.
Nagarajan R, Robison LL. Pregnancy outcomes in survivors of childhood cancer. J Natl Cancer Inst Monogr. 2005;34:72–6.
Tawn EJ, et al. Chromosome analysis in childhood cancer survivors and their offspring—no evidence for radiotherapy-induced persistent genomic instability. Mutat Res. 2005;583(2):198–206.
Winther JF, et al. Radiotherapy for childhood cancer and risk for congenital malformations in offspring: a population-based cohort study. Clin Genet. 2009;75(1):50–6.
Stahl O, et al. Risk of birth abnormalities in the offspring of men with a history of cancer: a cohort study using Danish and Swedish national registries. J Natl Cancer Inst. 2011;103(5):398–406.
Winther JF, et al. Hospitalizations among children of survivors of childhood and adolescent cancer: a population-based cohort study. Int J Cancer. 2010;127(12):2879–87.
Amant F, et al. Pediatric outcome after maternal cancer diagnosed during pregnancy. N Engl J Med. 2015;373(19):1824–34.
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Balcerek, M., Borgmann-Staudt, A., Findeklee, S., von Wolff, M. (2021). Pregnancy and Birth After Cancer in the Youth. In: Beck, J.D., Bokemeyer, C., Langer, T. (eds) Late Treatment Effects and Cancer Survivor Care in the Young. Springer, Cham. https://doi.org/10.1007/978-3-030-49140-6_12
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DOI: https://doi.org/10.1007/978-3-030-49140-6_12
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