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The Penn State Pediatric Total Artificial Heart

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Mechanical Support for Heart Failure

Abstract

There is an unmet need for total circulatory support in infants on the waiting list for heart transplantation. Congenital defects and pulmonary dysfunction often require right heart support in addition to systemic support. Penn State is developing a pediatric total artificial heart (TAH) based on a 12 ml pulsatile VAD currently in preclinical testing. The TAH consists of independent left and right pulsatile pumps designed for orthotopic placement. An automatic control system ensures full-to-empty operation, estimates inlet and outlet pressures, and controls right pump output to safely limit left atrial pressure. A portable pneumatic driver has been developed. The TAH has been tested in a juvenile ovine model.

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Acknowledgments

Thanks to Patrick Leibich, Kirby Bletcher, Bradley Doxtater, and Eric Yeager for their outstanding fabrication skills; Gerson Rosenberg, PhD, for design input; Heidi Finicle, Dr. John L. Myers, and Dr. William S. Pierce for their assistance in surgical planning and animal surgery; perfusionists Robert Wise, Karl Woitas, and Gary Irwin; John Reibson and Branka Lukic for instrumentation support; Choon-Sik Jhun, PhD, and Chris Scheib for valve analysis; and surgical technologists Dolly Schepps and Nate Shanaman.

Funding Source

This research is supported by NIH grant R01HL131921.

OPTN/SRTR 2016 Annual Data Report is not copyrighted. Readers are free to duplicate and use all or part of the information contained in this publication. Data are not copyrighted and may be used without permission if appropriate citation information is provided.

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Authors and Affiliations

  1. The Pennsylvania State University, College of Medicine, Department of Surgery, Division of Applied Biomedical Engineering, Hershey, PA, USA

    William J. Weiss PhD & Raymond Newswanger PhD

  2. The Pennsylvania State University, College of Medicine, Department of Pediatrics, Hershey, PA, USA

    J. Brian Clark MD

  3. The Pennsylvania State University, College of Medicine, Department of Comparative Medicine, Hershey, PA, USA

    Jenelle M. Izer DVM

Authors
  1. William J. Weiss PhD
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  2. Raymond Newswanger PhD
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  3. J. Brian Clark MD
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  4. Jenelle M. Izer DVM
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Corresponding author

Correspondence to William J. Weiss PhD .

Editor information

Editors and Affiliations

  1. Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Jamshid H. Karimov

  2. Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Kiyotaka Fukamachi

  3. Kaufman Center for Heart Failure Heart, Thoracic, and Vascular Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Randall C. Starling

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Weiss, W.J., Newswanger, R., Clark, J.B., Izer, J.M. (2020). The Penn State Pediatric Total Artificial Heart. In: Karimov, J., Fukamachi, K., Starling, R. (eds) Mechanical Support for Heart Failure . Springer, Cham. https://doi.org/10.1007/978-3-030-47809-4_36

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  • DOI: https://doi.org/10.1007/978-3-030-47809-4_36

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-47808-7

  • Online ISBN: 978-3-030-47809-4

  • eBook Packages: MedicineMedicine (R0)

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