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FDG–PET Imaging in TB: Patient Preparation and Imaging

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PET/CT in Tuberculosis

Part of the book series: Clinicians’ Guides to Radionuclide Hybrid Imaging ((PET/CT))

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Abstract

Fluorine-18-fluorodeoxyglucose–positron emission tomography (18F-FDG-PET)/computed tomography (CT) is diagnostic tomographic imaging for the detection of metabolic activity in the human body. FDG is an analog of glucose which enters into viable cells via cell membrane glucose transporters and phosphorylated with hexokinase inside cells. FDG is labeled with 18F, which is a cyclotron-produced radioisotope. The ability of 18F-FDG-PET/CT to detect sites of inflammation and infection is based on the high glycolytic activity of the cells involved in the inflammatory response. In the imaging analysis and interpretation it is important to be aware of physiological distribution of 18F-FDG on the PET scan. Visual, qualitative analysis means looking for increased physiological 18F-FDG uptake in whole body PET scan. It is important to take into account pattern and intensity of uptake and morphological information obtained by CT. Quantitative parameters, such as standardized uptake values (SUVmax), should be used with caution in patients with TB because it is not yet validated in literature and clinical practice. However, it could be of value for monitoring the response of the disease to the therapy.

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Author information

Authors and Affiliations

  1. Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Vera Artiko

  2. Center for Nuclear Medicine, Clinical Center of Serbia, Belgrade, Serbia

    Vera Artiko & Jelena Pantovic

Authors
  1. Vera Artiko
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  2. Jelena Pantovic
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Editor information

Editors and Affiliations

  1. Center for Nuclear Medicine, Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Belgrade, Serbia

    Dragana Sobic Saranovic

  2. Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa

    Mariza Vorster

  3. Deptartment of Nuclear Medicine, Sanjay Gandhi Post Graduate Institute of Lucknow, Lucknow, India

    Sanjay Gambhir

  4. Nuclear Medicine and Diagnostic Imaging, International Atomic Energy Agency, Wien-Vereinte Nationen, Wien, Austria

    Thomas Neil Pascual

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Artiko, V., Pantovic, J. (2020). FDG–PET Imaging in TB: Patient Preparation and Imaging. In: Sobic Saranovic, D., Vorster, M., Gambhir, S., Pascual, T. (eds) PET/CT in Tuberculosis. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-030-47009-8_5

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  • DOI: https://doi.org/10.1007/978-3-030-47009-8_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-47008-1

  • Online ISBN: 978-3-030-47009-8

  • eBook Packages: MedicineMedicine (R0)

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