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Biopolymeric Gels in Drug Delivery

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Advanced Biopolymeric Systems for Drug Delivery

Part of the book series: Advances in Material Research and Technology ((AMRT))

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Abstract

Biopolymers or the natural polysaccharides like alginate, chitosan, pectin, cellulose and their derivatives, etc., have been used in recent research studies for a number of significant advantages like their biocompatibility, biodegradability, safety, and cost-effectivity. They have been evaluated in a number of formulation strategies including matrix tablets, microencapsulation, nanoparticulate delivery, targeted drug delivery in various parts of the gastrointestinal tract according to pH or microbial population, etc. Further, they have been extensively utilized in the formation of gels by physical or chemical cross-linking methods for advanced drug delivery. Such biopolymeric gels find applications not only in controlled or targeted drug delivery but also in biomedical fields. Such gel formulations would provide controlled or targeted drug release based on their physicochemical properties including thermal sensitivity, pH sensitivity, analyte sensitivity or presence or absence of microbial population, etc. Recent inventions in this field include the smart gels which produce significant changes in drug delivery with minimum changes in the environment or the in situ gels which remain in the liquid state outside the body and would turn into gel at body temperature, once delivered. Further, modified or grafted biopolymers have been tried out for the formation of stable gels with favorable physicochemical properties for better control on drug delivery. The present chapter would present a review of the potential biopolymeric gels, their preparation, characterization, and most importantly their applications in modern drug delivery taking into account the recent innovations in the area.

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  1. School of Pharmaceutical Technology, Adamas University, Kolkata, India

    Moumita Das Kirtania, Nancy Kahali & Arindam Maity

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  1. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj, Odisha, India

    Amit Kumar Nayak

  2. Department of Pharmacy, Shri Venkateshwara University, Rajabpur, Gajraula, Uttar Pradesh, India

    Md Saquib Hasnain

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Kirtania, M.D., Kahali, N., Maity, A. (2020). Biopolymeric Gels in Drug Delivery. In: Nayak, A., Hasnain, M. (eds) Advanced Biopolymeric Systems for Drug Delivery. Advances in Material Research and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-46923-8_3

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