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Mechanisms and Dynamics of the Bacterial Flagellar Motor

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Physical Microbiology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1267))

Abstract

Many bacteria are able to actively propel themselves through their complex environment, in search of resources and suitable niches. The source of this propulsion is the Bacterial Flagellar Motor (BFM), a molecular complex embedded in the bacterial membrane which rotates a flagellum. In this chapter we review the known physical mechanisms at work in the motor. The BFM shows a highly dynamic behavior in its power output, its structure, and in the stoichiometry of its components. Changes in speed, rotation direction, constituent protein conformations, and the number of constituent subunits are dynamically controlled in accordance to external chemical and mechanical cues. The mechano-sensitivity of the motor is likely related to the surface-sensing ability of bacteria, relevant in the initial stage of biofilm formation.

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Acknowledgements

This work was supported by the ANR FlagMotor project grant ANR-18-CE30-0008 of the French Agence Nationale de la Recherche. The CBS is a member of the France-BioImaging (FBI) and the French Infrastructure for Integrated Structural Biology (FRISBI), 2 national infrastructures supported by the French National Research Agency (ANR-10-INBS-04-01 and ANR-10-INBS-05, respectively).

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  1. Centre de Biochimie Structurale (CBS), INSERM, CNRS, University of Montpellier, Montpellier, France

    A. L. Nord & F. Pedaci

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  1. A. L. Nord
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  1. Pathogenesis of Vascular Infections, Institut Pasteur, Paris, France

    Guillaume Duménil

  2. Microbial Morphogenesis and Growth, Institut Pasteur, Paris, France

    Sven van Teeffelen

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Nord, A.L., Pedaci, F. (2020). Mechanisms and Dynamics of the Bacterial Flagellar Motor. In: Duménil, G., van Teeffelen, S. (eds) Physical Microbiology. Advances in Experimental Medicine and Biology, vol 1267. Springer, Cham. https://doi.org/10.1007/978-3-030-46886-6_5

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