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Physical Views on ParABS-Mediated DNA Segregation

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Physical Microbiology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1267))

Abstract

In this chapter, we will focus on ParABS: an apparently simple, three-component system, required for the segregation of bacterial chromosomes and plasmids. We will specifically describe how biophysical measurements combined with physical modeling advanced our understanding of the mechanism of ParABS-mediated complex assembly, segregation and positioning.

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Abbreviations

DNA:

deoxyribonucleic acid

GTP:

guanosine triphosphate

ATP:

adenosine triphosphate

NTP:

nucleoside triphosphate

CBP:

centromere binding protein

Ori :

replication origin region

Ter :

replication termination region

nsDNA:

non-specific DNA

Kb:

kilobase

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Authors and Affiliations

  1. Centre de Biochimie Structurale, CNRS UMR 5048, INSERM U1054, Université de Montpellier, Montpellier, France

    Baptiste Guilhas, Antoine Le Gall & Marcello Nollmann

Authors
  1. Baptiste Guilhas
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  2. Antoine Le Gall
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  3. Marcello Nollmann
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Correspondence to Marcello Nollmann .

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Editors and Affiliations

  1. Pathogenesis of Vascular Infections, Institut Pasteur, Paris, France

    Guillaume Duménil

  2. Microbial Morphogenesis and Growth, Institut Pasteur, Paris, France

    Sven van Teeffelen

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Guilhas, B., Le Gall, A., Nollmann, M. (2020). Physical Views on ParABS-Mediated DNA Segregation. In: Duménil, G., van Teeffelen, S. (eds) Physical Microbiology. Advances in Experimental Medicine and Biology, vol 1267. Springer, Cham. https://doi.org/10.1007/978-3-030-46886-6_3

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