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Hypothermic Machine Perfusion in Liver Transplantation Using Grafts From Donation After Circulatory Death Donors

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Donation after Circulatory Death (DCD) Liver Transplantation

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Abstract

Dynamic preservation strategies are a promising option to improve graft quality and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which is based on physiologic conditions, thereby aiming to simulate the human body, hypothermic oxygenated liver perfusion appears un-physiologic and induces a unique, mitochondrial response for its protective effect. Both ex vivo perfusion techniques can be used for viability assessment, which will open the door for an increased liver utilization in the future.

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Authors and Affiliations

  1. Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, West Midlands, UK

    Andrea Schlegel

  2. Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland

    Matteo Mueller & Philipp Dutkowski

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  1. Andrea Schlegel
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  2. Matteo Mueller
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  3. Philipp Dutkowski
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Correspondence to Philipp Dutkowski .

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Editors and Affiliations

  1. Department of Transplant, Mayo Clinic, Jacksonville, FL, USA

    Kristopher P. Croome

  2. Queen Elizabeth Hospital Birmingham, Birmingham, UK

    Paolo Muiesan

  3. Department of Transplant, Mayo Clinic, Jacksonville, FL, USA

    C. Burcin Taner

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Schlegel, A., Mueller, M., Dutkowski, P. (2020). Hypothermic Machine Perfusion in Liver Transplantation Using Grafts From Donation After Circulatory Death Donors. In: Croome, K., Muiesan, P., Taner, C. (eds) Donation after Circulatory Death (DCD) Liver Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-46470-7_13

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  • DOI: https://doi.org/10.1007/978-3-030-46470-7_13

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