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Recent Advances on Nanostructured Materials for Drug Delivery and Release

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Nanopharmaceuticals: Principles and Applications Vol. 2

Part of the book series: Environmental Chemistry for a Sustainable World ((ECSW,volume 47))

Abstract

Nanomedicine has become a hot field of research, as it has the potential for developing several innovations in healthcare and, in particular, new pharmaceutical formulations. The need of innovative ways for drug transportation and delivery has accelerated the advances in the field of nanomaterials for pharmaceutical applications. The ultimate purpose of designing nanomaterials for drug delivery must be to ensure that the drug to be released exerts its pharmacological effect at the lowest possible dose, with the least number of side effects and equal benefits to a high dose. These so-called “nanopharmaceuticals” may possess distinctive features useful to improve the stability of the drugs, extend their systemic half-lives, enhance efficiency, increase bioavailability, and delay clearance. There is no doubt that nanopharmaceuticals are a promising strategy to overcome traditional pharmacokinetic limitations. Researchers around the world have been making important efforts to design and test novel nanoformulations, especially in in vitro and in vivo model studies. Virtually, all routes of drug administration have been investigated at this level. Compared to the high number of nanoformulations that are currently in the discovery and preclinical stages of the development pipeline, there are still very few nanopharmaceuticals in clinical trials and even less already in the market. This current scenario points to the need to accelerate nanomedicine endeavors in order to spur these formulations through the drug discovery pipeline.

In this chapter, we will present some of the several opportunities for the design and use of nanomaterials (nanoliposomes, micelles, carbon nanostructures, dendrimers, polymeric, and inorganic nanoparticles) for pharmaceutical formulations. The experimental challenges, associated with moving from bench to bedside, will be addressed, as well as concerns about the precise control of drug release, their biodistribution or fate, and their toxicity, especially when they do not biodegrade. The need to validate and standardize protocols for early detection of toxicity, as well as an in depth understanding of the interaction among nanoparticles and tissues, organs, cells, and biomolecules, will be stated. Finally, the importance of developing a close interaction between scientists, regulators, institutions, and industry in order to help accelerate the efforts in the field will be indicated. The application of several innovative approaches to the design of new nanopharmaceuticals may allow achieving innovation and disruptive advances, providing safe, convenient, and cost-effective drug formulations to patients.

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Authors and Affiliations

  1. Departamento de Ciencias Químico-Biológicas, Universidad de las Américas Puebla, Puebla, México

    Lucila Isabel Castro-Pastrana, Jessica Andrea Flood-Garibay, Dulce Alitzel Quintana-Romero, Pablo Crespo-Morán & Miguel Ángel Méndez-Rojas

  2. Departamento de Ciencias Químico-Biológicas/DIFUS, Universidad de Sonora, Hermosillo, Sonora, México

    Aracely Angulo Molina

Authors
  1. Lucila Isabel Castro-Pastrana
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  2. Aracely Angulo Molina
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  3. Jessica Andrea Flood-Garibay
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  4. Dulce Alitzel Quintana-Romero
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  5. Pablo Crespo-Morán
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  6. Miguel Ángel Méndez-Rojas
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Correspondence to Miguel Ángel Méndez-Rojas .

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Editors and Affiliations

  1. Animal Biotechnology Centre, National Dairy Research Institute, Karnal, India

    Vinod Kumar Yata

  2. Faculty of Engineering and Built Environment, University of Johannesburg, Johannesburg, South Africa

    Shivendu Ranjan

  3. Department of Biotechnology, Institute of Engineering and Technology, Lucknow, Uttar Pradesh, India

    Nandita Dasgupta

  4. CNRS, IRD, INRAE, Coll France, CEREGE, Aix-Marseille University, Aix-en-Provence, France

    Eric Lichtfouse

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Castro-Pastrana, L.I., Angulo Molina, A., Flood-Garibay, J.A., Quintana-Romero, D.A., Crespo-Morán, P., Méndez-Rojas, M.Á. (2021). Recent Advances on Nanostructured Materials for Drug Delivery and Release. In: Yata, V., Ranjan, S., Dasgupta, N., Lichtfouse, E. (eds) Nanopharmaceuticals: Principles and Applications Vol. 2. Environmental Chemistry for a Sustainable World, vol 47. Springer, Cham. https://doi.org/10.1007/978-3-030-44921-6_9

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